{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:48:37Z","timestamp":1753876117014,"version":"3.41.2"},"reference-count":42,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"vor","delay-in-days":307,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the last decade, genomics data have been largely adopted to sketch, study and better understand the complex mechanisms that underlie biological processes. The amount of publicly available data sources has grown accordingly, and several types of regulatory interactions have been collected and documented in literature. Unfortunately, often these efforts do not follow any data naming\/interoperability\/formatting standards, resulting in high-quality but often uninteroperable heterogeneous data repositories. To efficiently take advantage of the large amount of available data and integrate these heterogeneous sources of information, we built the RING (Regulatory Interaction Graph), an integrative standardized multilevel database of biological interactions able to provide a comprehensive and unmatched high-level perspective on several phenomena that take place in the regulatory cascade and that researchers can use to easily build regulatory networks around entities of interest.<\/jats:p>","DOI":"10.1093\/database\/baz108","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T19:12:11Z","timestamp":1566069131000},"source":"Crossref","is-referenced-by-count":7,"title":["\u2018One DB to rule them all\u2019\u2014the RING: a Regulatory INteraction Graph combining TFs, genes\/proteins, SNPs, diseases and drugs"],"prefix":"10.1093","volume":"2019","author":[{"given":"Gianfranco","family":"Politano","sequence":"first","affiliation":[{"name":"Control and Computer Engineering Department, Politecnico di Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Di Carlo","sequence":"additional","affiliation":[{"name":"Control and Computer Engineering Department, Politecnico di Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-7739","authenticated-orcid":false,"given":"Alfredo","family":"Benso","sequence":"additional","affiliation":[{"name":"Control and Computer Engineering Department, Politecnico di Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"2019110408155970600_ref1","doi-asserted-by":"crossref","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","article-title":"The Reactome pathway knowledgebase","volume":"46","author":"Fabregat","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019110408155970600_ref2","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2019110408155970600_ref3","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nmeth.2561","article-title":"Mentha: a resource for browsing integrated protein-interaction networks","volume":"10","author":"Calderone","year":"2013","journal-title":"Nat. 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