{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:38:17Z","timestamp":1775914697653,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":308,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bose National Fellowship"},{"DOI":"10.13039\/501100010803","name":"Department of Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific & Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006143","name":"Department of Science & Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>RareLSD is a manually curated database of lysosomal enzymes associated with rare diseases that maintains comprehensive information of 63 unique lysosomal enzymes and 93 associated disorders. Each entry provides a complete information on the disorder that includes the name of the disease, organ affected, age of onset, available drug, inheritance pattern, defected enzyme and single nucleotide polymorphism. To facilitate users in designing drugs against these diseases, we predicted and maintained structures of lysosomal enzymes. Our information portal also contains information on biochemical assays against disease-associated enzymes obtained from PubChem. Each lysosomal entry is supported by information that includes disorders, inheritance pattern, drugs, family members, active inhibitors, etc. Eventually, a user-friendly web interface has been developed to facilitate the users in searching and browsing data in RareLSD with a wide range of options. RareLSD is integrated with sequence similarity search tools (e.g. BLAST and Smith-Waterman algorithm) for analysis. It is built on responsive templates that are compatible with most of browsers and screens including smartphones and gadgets (mobile, iPhone, iPad, tablets, etc.).<\/jats:p>","DOI":"10.1093\/database\/baz112","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T19:12:11Z","timestamp":1566069131000},"source":"Crossref","is-referenced-by-count":4,"title":["RareLSD: a manually curated database of lysosomal enzymes associated with rare diseases"],"prefix":"10.1093","volume":"2019","author":[{"given":"Sana","family":"Akhter","sequence":"first","affiliation":[{"name":"Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi 110020, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi 110020, India"},{"name":"CSIR-Institute of Microbial Technology, Chandigarh 160036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyush","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi 110020, India"},{"name":"CSIR-Institute of Microbial Technology, Chandigarh 160036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-2876","authenticated-orcid":false,"given":"Gajendra P S","family":"Raghava","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi 110020, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"2019110507562252300_ref1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/mgg3.315","article-title":"Living with a rare disorder: a systematic review of the qualitative literature","volume":"51","author":"von der Lippe","year":"2017","journal-title":"Mol. 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