{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:35:00Z","timestamp":1778636100202,"version":"3.51.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":308,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670851"],"award-info":[{"award-number":["31670851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1306605"],"award-info":[{"award-number":["2016YFC1306605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial infarction (MI) is a common cardiovascular disease and a leading cause of death worldwide. The etiology of MI is complicated and not completely understood. Many risk factors are reported important for the development of MI, including lifestyle factors, environmental factors, psychosocial factors, genetic factors, etc. Identifying individuals with an increased risk of MI is urgent and a major challenge for improving prevention. The MI risk knowledge base (MIRKB) is developed for facilitating MI research and prevention. The goal of MIRKB is to collect risk factors and models related to MI to increase the efficiency of systems biological level understanding of the disease. MIRKB contains 8436 entries collected from 4366 articles in PubMed before 5 July 2019 with 7902 entries for 1847 single factors, 195 entries for 157 combined factors and 339 entries for 174 risk models. The single factors are classified into the following five categories based on their characteristics: molecular factor (2356 entries, 649 factors), imaging (821 entries, 252 factors), physiological factor (1566 entries, 219 factors), clinical factor (2523 entries, 561 factors), environmental factor (46 entries, 26 factors), lifestyle factor (306 entries, 65 factors) and psychosocial factor (284 entries, 75 factors). MIRKB will be helpful to the future systems level unraveling of the complex mechanism of MI genesis and progression.<\/jats:p>","DOI":"10.1093\/database\/baz125","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T19:36:36Z","timestamp":1570044996000},"source":"Crossref","is-referenced-by-count":20,"title":["MIRKB: a myocardial infarction risk knowledge base"],"prefix":"10.1093","volume":"2019","author":[{"given":"Chaoying","family":"Zhan","sequence":"first","affiliation":[{"name":"Centre for Systems Biology, Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manhong","family":"Shi","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology, Soochow University, Suzhou 215006, China"},{"name":"College of Information and Network Engineering, Anhui Science and Technology University, Fengyang, Anhui 233100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongrong","family":"Wu","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology, Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"He","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology, Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology, Soochow University, Suzhou 215006, China"},{"name":"Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bairong","family":"Shen","sequence":"additional","affiliation":[{"name":"Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"2019110507460110700_ref1","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"2019110507460110700_ref2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/jfmpc.jfmpc_297_18","article-title":"Preintensive care: thrombolytic (streptokinase or tenecteplase) in ST elevated acute myocardial infarction at peripheral hospital","volume":"8","author":"Bawaskar","year":"2019","journal-title":"J Family Med Prim Care"},{"key":"2019110507460110700_ref3","first-page":"98","article-title":"Different treatments for acute myocardial infarction patients via outpatient clinics and emergency department","volume":"e13883","author":"Chien","year":"2019","journal-title":"Medicine"},{"key":"2019110507460110700_ref4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.23736\/S0026-4806.18.05633-1","article-title":"The effects of atorvastatin on interventional therapy in patients with acute myocardial infarction","volume":"110","author":"Wang","year":"2019","journal-title":"Minerva Med."},{"key":"2019110507460110700_ref5","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1177\/2047487318788396","article-title":"Incidence and mortality of myocardial infarction among Catalonian older adults with and without underlying risk conditions: the CAPAMIS study","volume":"25","author":"Forcadell","year":"2018","journal-title":"Eur. J. Prev. Cardiol."},{"key":"2019110507460110700_ref6","first-page":"88","article-title":"Obesity and risk of myocardial infarction in a sample of European males. Waist to-hip-ratio presents information bias of the real risk of abdominal obesity","volume":"34","author":"Martin Castellanos","year":"2017","journal-title":"Nutr. Hosp."},{"key":"2019110507460110700_ref7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.amepre.2018.05.004","article-title":"Association between electronic cigarette use and myocardial infarction","volume":"55","author":"Alzahrani","year":"2018","journal-title":"Am. J. Prev. Med."},{"key":"2019110507460110700_ref8","doi-asserted-by":"crossref","first-page":"e0193360","DOI":"10.1371\/journal.pone.0193360","article-title":"Mediterranean diet adherence and synergy with acute myocardial infarction and its determinants: a multicenter case-control study in Italy","volume":"13","author":"La Torre","year":"2018","journal-title":"PLoS One"},{"key":"2019110507460110700_ref9","first-page":"5166","article-title":"Influence of interleukin-1beta gene polymorphism on the risk of myocardial infarction complicated with ischemic stroke","volume":"16","author":"Chen","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"2019110507460110700_ref10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12944-019-1042-3","article-title":"Effects of familial hypercholesterolemia-associated genes on the phenotype of premature myocardial infarction","volume":"18","author":"Lee","year":"2019","journal-title":"Lipids Health Dis."},{"key":"2019110507460110700_ref11","doi-asserted-by":"crossref","first-page":"e000620","DOI":"10.1136\/openhrt-2017-000620","article-title":"The impact of passive and active smoking on inflammation, lipid profile and the risk of myocardial infarction","volume":"4","author":"Attard","year":"2017","journal-title":"Open Heart"},{"key":"2019110507460110700_ref12","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ccd.28096","article-title":"Predictors of mortality in patients with non-anterior ST-segment elevation myocardial infarction: analysis from the HORIZONS-AMI trial","volume":"94","author":"Huang","year":"2019","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"2019110507460110700_ref13","first-page":"809","article-title":"Renyi distribution entropy aalysis of short-term heart rate variability signals and its application in coronary artery disease detection","volume-title":"Front. Physiol.","author":"Shi","year":"2019"},{"key":"2019110507460110700_ref14","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/jech.56.9.702","article-title":"Importance of light smoking and inhalation habits on risk of myocardial infarction and all cause mortality. A 22 year follow up of 12 149 men and women in the Copenhagen City heart study","volume":"56","author":"Prescott","year":"2002","journal-title":"J. Epidemiol. Community Health"},{"key":"2019110507460110700_ref15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/ehjci\/jew030","article-title":"Association of smoking with myocardial injury and clinical outcome in patients undergoing mechanical reperfusion for ST-elevation myocardial infarction","volume":"18","author":"Reinstadler","year":"2017","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"2019110507460110700_ref16","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/postgradmedj-2016-134605","article-title":"A retrospective cohort study of the association between smoking and mortality after acute ST-segment elevation myocardial infarction","volume":"93","author":"Steele","year":"2017","journal-title":"Postgrad. Med. J."},{"key":"2019110507460110700_ref17","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s00392-018-1360-x","article-title":"Physical inactivity and smoking after myocardial infarction as predictors for readmission and survival: results from the SWEDEHEART-registry","volume":"108","author":"Ek","year":"2019","journal-title":"Clin. Res. Cardiol."},{"key":"2019110507460110700_ref18","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009554","article-title":"Effects of leisure-time and transport-related physical activities on the risk of incident and recurrent myocardial infarction and interaction with traffic-related air pollution: a cohort study","volume":"7","author":"Kubesch","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"2019110507460110700_ref19","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/2047487312465525","article-title":"Association of risk factors with acute myocardial infarction in middle eastern countries: the INTERHEART Middle East study","volume":"21","author":"Gehani","year":"2014","journal-title":"Eur. J. Prev. Cardiol."},{"key":"2019110507460110700_ref20","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.amjcard.2018.06.027","article-title":"Usefulness of higher levels of cardiac troponin T in patients with stable angina pectoris to predict risk of acute myocardial infarction","volume":"122","author":"Vavik","year":"2018","journal-title":"Am. J. Cardiol."},{"key":"2019110507460110700_ref21","doi-asserted-by":"crossref","first-page":"198","DOI":"10.5603\/KP.a2018.0245","article-title":"Impact of sex on the follow-up course and predictors of clinical outcomes in patients hospitalised due to myocardial infarction with non-obstructive coronary arteries: a single-Centre experience","volume":"77","author":"Jedrychowska","year":"2019","journal-title":"Kardiol. Pol."},{"key":"2019110507460110700_ref22","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1067\/mhj.2003.184","article-title":"A score predicts failure of reperfusion after fibrinolytic therapy for acute myocardial infarction","volume":"145","author":"French","year":"2003","journal-title":"Am. Heart J."},{"key":"2019110507460110700_ref23","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.athoracsur.2015.11.034","article-title":"Accuracy of myocardial biomarkers in the diagnosis of myocardial infarction after revascularization as assessed by cardiac resonance: the medicine, angioplasty, surgery study V (MASS-V) trial","volume":"101","author":"Hueb","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"2019110507460110700_ref24","first-page":"87","article-title":"Creatine kinase-MB and red cell distribution width as predictors of contrast-induced nephropathy after percutaneous coronary intervention in acute myocardial infarction","volume":"57","author":"Zbierska-Rubinkiewicz","year":"2017","journal-title":"Folia Med. Cracov."},{"key":"2019110507460110700_ref25","doi-asserted-by":"crossref","first-page":"e12593","DOI":"10.1111\/anec.12593","article-title":"Fragmented QRS as a predictor of in-hospital life-threatening arrhythmic complications in ST-elevation myocardial infarction patients","volume":"24","author":"Attachaipanich","year":"2019","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2019110507460110700_ref26","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1536\/ihj.18-306","article-title":"Serum circulating miR-150 is a predictor of post-acute myocardial infarction heart failure","volume":"60","author":"Lin","year":"2019","journal-title":"Int. Heart J."},{"key":"2019110507460110700_ref27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11883-015-0548-z","article-title":"MicroRNA biomarkers for coronary artery disease?","volume":"17","author":"Kaudewitz","year":"2015","journal-title":"Curr. Atheroscler. Rep."},{"key":"2019110507460110700_ref28","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.exger.2015.10.011","article-title":"Plasma miR-1, miR-208, miR-499 as potential predictive biomarkers for acute myocardial infarction: an independent study of Han population","volume":"72","author":"Liu","year":"2015","journal-title":"Exp. Gerontol."},{"key":"2019110507460110700_ref29","doi-asserted-by":"crossref","first-page":"811","DOI":"10.7150\/ijbs.4439","article-title":"Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction","volume":"8","author":"Long","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"2019110507460110700_ref30","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.21037\/jtd.2018.05.141","article-title":"Sensitive miRNA markers for the detection and management of NSTEMI acute myocardial infarction patients","volume":"10","author":"Liu","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"2019110507460110700_ref31","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1253\/circj.CJ-16-0568","article-title":"Circulating miR-122-5p\/miR-133b ratio is a specific early prognostic biomarker in acute myocardial infarction","volume":"80","author":"Cortez-Dias","year":"2016","journal-title":"Circ. J."},{"key":"2019110507460110700_ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/bay046","article-title":"CBD: a biomarker database for colorectal cancer","volume":"2018","author":"Zhang","year":"2018","journal-title":"Database (Oxford)"},{"key":"2019110507460110700_ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/bay100","article-title":"AGD: aneurysm gene database","volume":"2018","author":"Sun","year":"2018","journal-title":"Database (Oxford)"},{"key":"2019110507460110700_ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/baz051","article-title":"GIDB: a knowledge database for the automated curation and multidimensional analysis of molecular signatures in gastrointestinal cancer","volume":"2019","author":"Wang","year":"2019","journal-title":"Database (Oxford)"},{"key":"2019110507460110700_ref35","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1161\/01.CIR.84.5.2123","article-title":"Role of collagen in acute myocardial infarct expansion","volume":"84","author":"Whittaker","year":"1991","journal-title":"Circulation"},{"key":"2019110507460110700_ref36","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrcardio.2014.188","article-title":"Intramyocardial haemorrhage after acute myocardial infarction","volume":"12","author":"Betgem","year":"2015","journal-title":"Nat. Rev. Cardiol."}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baz125\/30351633\/baz125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baz125\/30351633\/baz125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T20:57:44Z","timestamp":1664571464000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/baz125\/5612251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":36,"URL":"https:\/\/doi.org\/10.1093\/database\/baz125","relation":{},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019]]},"published":{"date-parts":[[2019,1,1]]},"article-number":"baz125"}}