{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:42:27Z","timestamp":1784698947011,"version":"3.55.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670851"],"award-info":[{"award-number":["31670851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1306605"],"award-info":[{"award-number":["2016YFC1306605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["18KJD520003"],"award-info":[{"award-number":["18KJD520003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The interaction between genes, lifestyles and environmental factors makes the genesis and progress of prostate cancer (PCa) very heterogeneous. Positive lifestyle is important to the prevention and controlling of PCa. To investigate the relationship between PCa and lifestyle at systems level, we established a PCa related lifestyle database (PCaLiStDB) and collected the PCa-related lifestyles including foods, nutrients, life habits and social and environmental factors as well as associated genes and physiological and biochemical indexes together with the disease phenotypes and drugs. Data format standardization was implemented for the future Lifestyle-Wide Association Studies of PCa (PCa_LWAS). Currently, 2290 single-factor lifestyles and 856 joint effects of two or more lifestyles were collected. Among these, 394 are protective factors, 556 are risk factors, 45 are no-influencing factors, 52 are factors with contradictory views and 1977 factors are lacking effective literatures support. PCaLiStDB is expected to facilitate the prevention and control of PCa, as well as the promotion of mechanistic study of lifestyles on PCa.<\/jats:p><jats:p>Database URL: http:\/\/www.sysbio.org.cn\/pcalistdb\/<\/jats:p>","DOI":"10.1093\/database\/baz154","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T20:15:53Z","timestamp":1576613753000},"source":"Crossref","is-referenced-by-count":11,"title":["PCaLiStDB: a lifestyle database for precision prevention of prostate cancer"],"prefix":"10.1093","volume":"2020","author":[{"given":"Yalan","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou 215006, China"},{"name":"Department of Medical Informatics, School of Medicine, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou 215006, China"},{"name":"Institutes for Systems Genetics, West China Hospital, Sichuan University, No.17 Gaopeng Avenue, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, School of Medicine, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou 215006, China"},{"name":"School of Nanotechnology, Suzhou Industrial Park Institute of Services Outsourcing, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou 215006, China"},{"name":"Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, School of Medicine, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, School of Medicine, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, School of Medicine, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bairong","family":"Shen","sequence":"additional","affiliation":[{"name":"Institutes for Systems Genetics, West China Hospital, Sichuan University, No.17 Gaopeng Avenue, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"2020011702262964300_ref1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/01.med.0000433056.76699.5d","article-title":"Lifestyle medicine: the future of chronic disease management","volume":"20","author":"Kushner","year":"2013","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"2020011702262964300_ref2","first-page":"661","article-title":"Development of a lifestyle medicine","volume":"48","author":"Egger","year":"2019","journal-title":"Aust J Gen 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