{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:23:01Z","timestamp":1767846181249,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["www.embopress.org"],"crossmark-restriction":false},"short-container-title":["EMBO Reports"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>\n                    Transgenic mice have been used to explore the role of chromosomal translocations in the genesis of tumors. But none of these efforts has actually involved induction of a translocation\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Here we report the use of Cre recombinase to replicate\n                    <jats:italic>in vivo<\/jats:italic>\n                    the t(8;21) translocation found in human acute myeloid leukemia (AML). As in the human tumors, the murine translocation fuses the genes\n                    <jats:italic>AML1<\/jats:italic>\n                    and\n                    <jats:italic>ETO<\/jats:italic>\n                    . We used homologous recombination to place loxP sites at loci that were syntenic with the break points for the human translocation. Cre activity was provided in mice by a transgene under the control of the Nestin promoter, or in cultured B cells by infecting with a retroviral vector encoding Cre. In both instances, Cre activity mediated interchromosomal translocations that fused the\n                    <jats:italic>AML1<\/jats:italic>\n                    and\n                    <jats:italic>ETO<\/jats:italic>\n                    genes. Thus, reciprocal chromosomal translocations that closely resemble rearrangements found in human cancers can be achieved in mice.\n                  <\/jats:p>","DOI":"10.1093\/embo-reports\/kvd027","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:48:15Z","timestamp":1027709295000},"page":"133-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Inducible chromosomal translocation of\n                    <i>AML1<\/i>\n                    and\n                    <i>ETO<\/i>\n                    genes through Cre\/loxP\u2010mediated recombination in the mouse"],"prefix":"10.1038","volume":"1","author":[{"given":"Frank","family":"Buchholz","sequence":"first","affiliation":[{"name":"Hooper Research Foundation, University of California San Francisco (UCSF)  513 Parnassus Avenue San Francisco CA 94143\u20100552 USA"}]},{"given":"Yosef","family":"Refaeli","sequence":"additional","affiliation":[{"name":"Hooper Research Foundation, University of California San Francisco (UCSF)  513 Parnassus Avenue San Francisco CA 94143\u20100552 USA"}]},{"given":"Andreas","family":"Trumpp","sequence":"additional","affiliation":[{"name":"Present address: ISREC, Swiss Institute for Experimental Cancer Research  Chemin des Boveresses 155 CH\u20101066 Epalinges Switzerland"}]},{"given":"J Michael","family":"Bishop","sequence":"additional","affiliation":[{"name":"Hooper Research Foundation, University of California San Francisco (UCSF)  513 Parnassus Avenue San Francisco CA 94143\u20100552 USA"}]}],"member":"297","published-online":{"date-parts":[[2000,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/5669"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.1.11"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81269-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/3861"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<157::AID-GENE19>3.0.CO;2-R"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5340.1059"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0497supp-417"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<99::AID-GENE1>3.0.CO;2-B"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199409049690"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.9.3134"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.15103"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118828"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/378720a0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80566-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.6.1427"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0495-376"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.23.3136"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.16.7376"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80103-X"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0397-303"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/2417"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90148-1"}],"container-title":["EMBO 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