{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:18:41Z","timestamp":1779344321308,"version":"3.51.4"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2000,8,1]]},"DOI":"10.1093\/embo-reports\/kvd032","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:48:15Z","timestamp":1027709295000},"page":"171-175","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["TIF\u2010IA, the factor mediating growth\u2010dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p"],"prefix":"10.1038","volume":"1","author":[{"given":"Jochen","family":"Bodem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergana","family":"Dobreva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Hoffmann\u2010Rohrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Iben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanswalter","family":"Zentgraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajo","family":"Delius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Vingron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Grummt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,8,1]]},"reference":[{"key":"BFEMBR605_CR1","first-page":"5010","volume":"14","author":"R.P. Brun","year":"1994","unstructured":"Brun, R.P., Ryan, K. and Sollner Webb, B. (1994) Factor C*, the specific initiation component of the mouse RNA polymerase I holoenzyme, is inactivated early in the transcription process. Mol. Cell. Biol., 14, 5010\u20135021.","journal-title":"Mol. Cell. Biol."},{"key":"BFEMBR605_CR2","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/sj.onc.1202402","volume":"18","author":"A. Budde","year":"1999","unstructured":"Budde, A. and Grummt, I. (1999) p53 represses ribosomal gene transcription. Oncogene, 18, 1119\u20131124.","journal-title":"Oncogene"},{"key":"BFEMBR605_CR3","doi-asserted-by":"crossref","first-page":"8165","DOI":"10.1093\/nar\/13.22.8165","volume":"13","author":"D. Buttgereit","year":"1985","unstructured":"Buttgereit, D., Pflugfelder, G. and Grummt, I. (1985) Growth\u2010dependent regulation of rRNA synthesis is mediated by a transcription initiation factor (TIF\u2010IA). Nucleic Acids Res., 13, 8165\u20138180.","journal-title":"Nucleic Acids Res."},{"key":"BFEMBR605_CR4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0079-6603(08)60506-1","volume":"62","author":"I. Grummt","year":"1999","unstructured":"Grummt, I. (1999) Regulation of mammalian ribosomal gene transcription by RNA polymerase I. Prog. Nucleic Acid Res. Mol. Biol., 62, 109\u2013154.","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"BFEMBR605_CR5","doi-asserted-by":"crossref","first-page":"16225","DOI":"10.1016\/S0021-9258(17)46212-0","volume":"265","author":"P.B. Mahajan","year":"1990","unstructured":"Mahajan, P.B. and Thompson, E.A. (1990) Hormonal regulation of transcription of rDNA. Purification and characterization of the hormone\u2010regulated transcription factor IC. J. Biol. Chem., 265, 16225\u201316233.","journal-title":"J. Biol. Chem."},{"key":"BFEMBR605_CR6","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1093\/emboj\/17.13.3692","volume":"17","author":"P. Milkereit","year":"1998","unstructured":"Milkereit, P. and Tschochner, H. (1998) A specialized form of RNA polymerase I, essential for initiation and growth\u2010dependent regulation of rRNA synthesis, is disrupted during transcription. EMBO J., 17, 3692\u20133703.","journal-title":"EMBO J."},{"key":"BFEMBR605_CR7","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1073\/pnas.080063997","volume":"97","author":"B. Moorefield","year":"2000","unstructured":"Moorefield, B., Greene, E.A. and Reeder, R.H. (2000) RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human. Proc. Natl Acad. Sci. USA, 97, 4724\u20134729.","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFEMBR605_CR8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0076-6879(96)73023-9","volume":"273","author":"A. Schnapp","year":"1996","unstructured":"Schnapp, A. and Grummt, I. (1996) Purification, assay and properties of RNA polymerase I and class I\u2010specific transcription factors in mouse. Methods Enzymol., 273, 233\u2013248.","journal-title":"Methods Enzymol."},{"key":"BFEMBR605_CR9","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1002\/j.1460-2075.1990.tb07475.x","volume":"9","author":"A. Schnapp","year":"1990","unstructured":"Schnapp, A., Pfleiderer, C., Rosenbauer, H. and Grummt, I. (1990) A growth\u2010dependent transcription initiation factor (TIF\u2010IA) interacting with RNA polymerase I regulates mouse ribosomal RNA synthesis. EMBO J., 9, 2857\u20132863.","journal-title":"EMBO J."},{"key":"BFEMBR605_CR10","first-page":"6723","volume":"13","author":"A. Schnapp","year":"1993","unstructured":"Schnapp, A., Schnapp, G., Erny, B. and Grummt, I. (1993) Function of the growth\u2010regulated transcription initiation factor TIF\u2010IA in initiation complex formation at the murine ribosomal gene promoter. Mol. Cell. Biol., 13, 6723\u20136732.","journal-title":"Mol. Cell. Biol."},{"key":"BFEMBR605_CR11","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/0092-8674(87)90514-9","volume":"50","author":"J. Tower","year":"1987","unstructured":"Tower, J. and Sollner\u2010Webb, B. (1987) Transcription of mouse rDNA is regulated by an activated subform of RNA polymerase I. Cell, 50, 873\u2013883.","journal-title":"Cell"},{"key":"BFEMBR605_CR12","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1002\/j.1460-2075.1996.tb00770.x","volume":"15","author":"R.T. Yamamoto","year":"1996","unstructured":"Yamamoto, R.T., Nogi, Y., Dodd, J.A. and Nomura, M. (1996) RRN3 gene of Saccharomyces cerevisiae encodes an essential RNA polymerase I transcription factor which interacts with the polymerase independently of DNA template. EMBO J., 15, 3964\u20133973.","journal-title":"EMBO J."},{"key":"BFEMBR605_CR13","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1073\/pnas.69.10.2833","volume":"69","author":"F.L. Yu","year":"1972","unstructured":"Yu, F.L. and Feigelson, P. (1972) The rapid turnover of RNA polymerase of rat liver nucleolus and of its messenger RNA. Proc. Natl Acad. Sci. USA, 69, 2833\u20132837.","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Fembo-reports%2Fkvd032","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/embo-reports\/kvd032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1093\/embo-reports\/kvd032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1093\/embo-reports\/kvd032\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.1093\/embo-reports\/kvd032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/embo-reports\/kvd032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:24:43Z","timestamp":1779107083000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1093\/embo-reports\/kvd032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8,1]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,8,1]]}},"alternative-id":["BFEMBR605"],"URL":"https:\/\/doi.org\/10.1093\/embo-reports\/kvd032","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8,1]]},"assertion":[{"value":"4 May 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2000","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2000","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2000","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}