{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:55:06Z","timestamp":1776664506654,"version":"3.51.2"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["www.embopress.org"],"crossmark-restriction":false},"short-container-title":["EMBO Reports"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p>\n                    To dissect the effects of corticosteroids mediated by the mineralocorticoid (MR) and the glucocorticoid receptor (GR) in the central nervous system, we compared MR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, whose salt loss syndrome was corrected by exogenous NaCl administration, with GR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice having a brain\u2010specific disruption of the GR gene generated by the Cre\/loxP\u2010recombination system. Neuropathological analyses revealed a decreased density of granule cells in the hippocampus of adult MR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice but not in mice with disruption of GR. Furthermore, adult MR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice exhibited a significant reduction of granule cell neurogenesis to 65% of control levels, possibly mediated by GR due to elevated corticosterone plasma levels. Neurogenesis was unaltered in adult mice with disruption of GR. Thus, we could attribute long\u2010term trophic effects of adrenal steroids on dentate granule cells to MR. These MR\u2010related alterations may participate in the pathogenesis of hippocampal changes observed in ageing, chronic stress and affective disorders.\n                  <\/jats:p>","DOI":"10.1093\/embo-reports\/kvd088","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:48:15Z","timestamp":1027709295000},"page":"447-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice"],"prefix":"10.1038","volume":"1","author":[{"given":"Peter","family":"Gass","sequence":"first","affiliation":[{"name":"Division Molecular Biology of the Cell I, German Cancer Research Center  Heidelberg Germany"},{"name":"Central Institute of Mental Health (ZI), J 5  68159 Mannheim Germany"}]},{"given":"Oliver","family":"Kretz","sequence":"additional","affiliation":[{"name":"Division Molecular Biology of the Cell I, German Cancer Research Center  Heidelberg Germany"}]},{"given":"David P","family":"Wolfer","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Z\u00fcrich  Winterthurer Stra\u00dfe 190 CH\u20108057 Z\u00fcrich Switzerland"}]},{"given":"Stefan","family":"Berger","sequence":"additional","affiliation":[{"name":"Division Molecular Biology of the Cell I, German Cancer Research Center  Heidelberg Germany"}]},{"given":"Francois","family":"Tronche","sequence":"additional","affiliation":[{"name":"Division Molecular Biology of the Cell I, German Cancer Research Center  Heidelberg Germany"}]},{"given":"Holger M","family":"Reichardt","sequence":"additional","affiliation":[{"name":"Division Molecular Biology of the Cell I, German Cancer Research Center  Heidelberg Germany"}]},{"given":"Christoph","family":"Kellendonk","sequence":"additional","affiliation":[{"name":"Division Molecular Biology of the Cell I, German Cancer Research Center  Heidelberg Germany"}]},{"given":"Hans\u2010Peter","family":"Lipp","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Z\u00fcrich  Winterthurer Stra\u00dfe 190 CH\u20108057 Z\u00fcrich Switzerland"}]},{"given":"Wolfgang","family":"Schmid","sequence":"additional","affiliation":[{"name":"Division Molecular Biology of the Cell I, German Cancer Research Center  Heidelberg Germany"}]},{"given":"G\u00fcnther","family":"Sch\u00fctz","sequence":"additional","affiliation":[{"name":"Division Molecular Biology of the Cell I, German Cancer Research Center  Heidelberg 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