{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:38:54Z","timestamp":1774453134300,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Young Elite Scientists","award":["2020QNRC001"],"award-info":[{"award-number":["2020QNRC001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Single-cell multi-omics sequencing has greatly accelerated reproductive research in recent years, and the data are continually growing. However, utilizing these data resources is challenging for wet-lab researchers. A comprehensive platform for exploring single-cell multi-omics data related to reproduction is urgently needed. Here, we introduce the single-cell multi-omics atlas of reproduction (SMARTdb), an integrative and user-friendly platform for exploring molecular dynamics of reproductive development, aging, and disease, which covers multi-omics, multi-species, and multi-stage data. We curated and analyzed single-cell transcriptomic and epigenomic data of over 2.0 million cells from 6 species across the entire lifespan. A series of powerful functionalities are provided, such as \u201cQuery gene expression\u201d, \u201cDIY expression plot\u201d, \u201cDNA methylation plot\u201d, and \u201cEpigenome browser\u201d. With SMARTdb, we found that the male germ cell-specific expression pattern of RPL39L and RPL10L is conserved between human and other model animals. Moreover, DNA hypomethylation and open chromatin may collectively regulate the specific expression pattern of RPL39L in both male and female germ cells. In summary, SMARTdb is a powerful platform for convenient data mining and gaining novel insights into reproductive development, aging, and disease. SMARTdb is publicly available at https:\/\/smart-db.cn.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzae005","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T23:33:00Z","timestamp":1704929580000},"source":"Crossref","is-referenced-by-count":10,"title":["SMARTdb: An Integrated Database for Exploring Single-cell Multi-omics Data of Reproductive Medicine"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2261-1216","authenticated-orcid":false,"given":"Zekai","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-6681","authenticated-orcid":false,"given":"Zhen","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2455-5508","authenticated-orcid":false,"given":"Yunlei","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8420-9033","authenticated-orcid":false,"given":"Ruilin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1319-7784","authenticated-orcid":false,"given":"Yusheng","family":"Guan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5068-3853","authenticated-orcid":false,"given":"Zhanglian","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6175-0042","authenticated-orcid":false,"given":"Yunan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1145-8306","authenticated-orcid":false,"given":"Tianlu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9423-0151","authenticated-orcid":false,"given":"Meining","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9662-113X","authenticated-orcid":false,"given":"Shuhui","family":"Bian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"2024100903564392200_qzae005-B1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41588-017-0007-6","article-title":"Single-cell DNA methylome sequencing of human preimplantation embryos","volume":"50","author":"Zhu","year":"2018","journal-title":"Nat Genet"},{"key":"2024100903564392200_qzae005-B2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41586-019-1500-0","article-title":"Reconstituting the transcriptome and DNA methylome landscapes of human implantation","volume":"572","author":"Zhou","year":"2019","journal-title":"Nature"},{"key":"2024100903564392200_qzae005-B3","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/s41467-021-21409-8","article-title":"Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos","volume":"12","author":"Wang","year":"2021","journal-title":"Nat 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