{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:12:53Z","timestamp":1768590773532,"version":"3.49.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2021YFF0703704"],"award-info":[{"award-number":["2021YFF0703704"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370717"],"award-info":[{"award-number":["32370717"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>T cells and T-cell receptors (TCRs) are essential components of the adaptive immune system. Characterization of the TCR repertoire offers a promising and highly informative source for understanding the functions of T cells in the immune response and immunotherapy. Although TCR repertoire studies have attracted much attention, there are few online servers available for TCR repertoire analysis, especially for TCR sequence annotation or advanced analyses. Therefore, we developed TCRosetta, a comprehensive online server that integrates analytical methods for TCR repertoire analysis and visualization. TCRosetta combines general feature analysis, large-scale sequence clustering, network construction, peptide\u2013TCR binding prediction, generation probability calculation, and k-mer motif analysis for TCR sequences, making TCR data analysis as simple as possible. The TCRosetta server accepts multiple input data formats and can analyze \u223c 20,000 TCR sequences in less than 3 min. TCRosetta is the most comprehensive web server available for TCR repertoire analysis and is freely available at https:\/\/guolab.wchscu.cn\/TCRosetta\/.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzae013","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:19:35Z","timestamp":1707437975000},"source":"Crossref","is-referenced-by-count":3,"title":["TCRosetta: An Integrated Analysis and Annotation Platform for T-cell Receptor Sequences"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-1433","authenticated-orcid":false,"given":"Tao","family":"Yue","sequence":"first","affiliation":[{"name":"Center for Artificial Intelligence Biology, Hubei Bioinformatics & Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-0576","authenticated-orcid":false,"given":"Si-Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Artificial Intelligence Biology, Hubei Bioinformatics & Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9168-4465","authenticated-orcid":false,"given":"Wen-Kang","family":"Shen","sequence":"additional","affiliation":[{"name":"Center for Artificial Intelligence Biology, Hubei Bioinformatics & Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8539-9877","authenticated-orcid":false,"given":"Zhan-Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Artificial Intelligence Biology, Hubei Bioinformatics & Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-5090","authenticated-orcid":false,"given":"Liming","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5099-7465","authenticated-orcid":false,"given":"An-Yuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Center for Artificial Intelligence Biology, Hubei Bioinformatics & Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074,","place":["China"]},{"name":"Department of Thoracic Surgery, West China Biomedical Big Data Center, West China Hospital, 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