{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:36:26Z","timestamp":1775280986352,"version":"3.50.1"},"reference-count":121,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ribonuclease P (RNase P) was first described in the 1970\u2019s as an endoribonuclease acting in the maturation of precursor transfer RNAs (tRNAs). More recent studies, however, have uncovered non-canonical roles for RNase P and its components. Here, we review the recent progress of its involvement in chromatin assembly, DNA damage response, and maintenance of genome stability with implications in tumorigenesis. The possibility of RNase P as a therapeutic target in cancer is also discussed.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzae016","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:50:00Z","timestamp":1707785400000},"source":"Crossref","is-referenced-by-count":4,"title":["RNase P: Beyond Precursor tRNA Processing"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7993-8813","authenticated-orcid":false,"given":"Peipei","family":"Wang","sequence":"first","affiliation":[{"name":"Guangdong Key Laboratory for Genome Stability & Disease Prevention and Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University , Shenzhen 518060,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-9621","authenticated-orcid":false,"given":"Juntao","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory for Genome Stability & Disease Prevention and Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University , Shenzhen 518060,","place":["China"]},{"name":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310000,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-3979","authenticated-orcid":false,"given":"Xiangyang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shenzhen University General Hospital-Dehua Hospital Joint Research Center on Precision Medicine, Dehua Hospital , Dehua 362500,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4459-2082","authenticated-orcid":false,"given":"Xingzhi","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory for Genome Stability & Disease Prevention and Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University , Shenzhen 518060,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"2024092609253202600_qzae016-B1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/newbio233035a0","article-title":"Tyrosine tRNA precursor molecule polynucleotide sequence","volume":"233","author":"Altman","year":"1971","journal-title":"Nat New Biol"},{"key":"2024092609253202600_qzae016-B2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0092-8674(83)90117-4","article-title":"The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme","volume":"35","author":"Guerrier-Takada","year":"1983","journal-title":"Cell"},{"key":"2024092609253202600_qzae016-B3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1101\/gr.087775.108","article-title":"MEN epsilon\/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of 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