{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:38:34Z","timestamp":1772138314770,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Protein N-phosphorylation is widely present in nature and participates in various biological processes. However, current knowledge on N-phosphorylation is extremely limited compared to that on O-phosphorylation. In this study, we collected 11,710 experimentally verified N-phosphosites of 7344 proteins from 39 species and subsequently constructed the database Nphos to share up-to-date information on protein N-phosphorylation. Upon these substantial data, we characterized the sequential and structural features of protein N-phosphorylation. Moreover, after comparing hundreds of learning models, we chose and optimized gradient boosting decision tree (GBDT) models to predict three types of human N-phosphorylation, achieving mean area under the receiver operating characteristic curve (AUC) values\u00a0of 90.56%, 91.24%, and 92.01% for pHis, pLys, and pArg, respectively. Meanwhile, we discovered 488,825 distinct N-phosphosites in the human proteome. The models were also deployed in Nphos for interactive N-phosphosite prediction. In summary, this work provides new insights and points for both flexible and focused investigations of N-phosphorylation. It will also facilitate a deeper and more systematic understanding of protein N-phosphorylation modification by providing a data and technical foundation. Nphos is freely available at http:\/\/www.bio-add.org\/Nphos\/ and http:\/\/ppodd.org.cn\/Nphos\/.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzae032","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T10:43:32Z","timestamp":1712745812000},"source":"Crossref","is-referenced-by-count":6,"title":["Nphos: Database and Predictor of Protein\n                    <i>N<\/i>\n                    -phosphorylation"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8821-3654","authenticated-orcid":false,"given":"Ming-Xiao","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University , Ningbo 315211,","place":["China"]},{"name":"Department of Chemical Biology, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen 361005,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-9866","authenticated-orcid":false,"given":"Ruo-Fan","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University , Xiamen 361102,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2624-8904","authenticated-orcid":false,"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Pathophysiology, Department of Biochemistry and Molecular Biology, Health Science Center, Ningbo University , Ningbo 315211,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9021-5114","authenticated-orcid":false,"given":"Junhua","family":"Meng","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen , Shenzhen 518083,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-7795","authenticated-orcid":false,"given":"Fulai","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University , Ningbo 315211,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3524-8108","authenticated-orcid":false,"given":"Songsen","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University , Ningbo 315211,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-8787","authenticated-orcid":false,"given":"Biling","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University , Ningbo 315211,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-7898","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology, Key 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