{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:08:55Z","timestamp":1774278535888,"version":"3.50.1"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Small cell lung cancer (SCLC) is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction models. Here, we analyzed formalin-fixed, paraffin-embedded (FFPE) samples of surgical resections by proteomic profiling, and stratified SCLC into three proteomic subtypes (S-I, S-II, and S-III) with distinct clinical outcomes and chemotherapy responses. The proteomic subtyping was an independent prognostic factor and performed better than current tumor\u2013node\u2013metastasis or Veterans Administration Lung Study Group staging methods. The subtyping results could be further validated using FFPE biopsy samples from an independent cohort, extending the analysis to both surgical and biopsy samples. The signatures of the S-II subtype in particular suggested potential benefits from immunotherapy. Differentially overexpressed proteins in S-III, the worst prognostic subtype, allowed us to nominate potential therapeutic targets, indicating that patient selection may bring new hope for previously failed clinical trials. Finally, analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line immunotherapy. Collectively, our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzae033","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T02:31:07Z","timestamp":1720060267000},"source":"Crossref","is-referenced-by-count":11,"title":["Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-0831","authenticated-orcid":false,"given":"Zitian","family":"Huo","sequence":"first","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"},{"name":"Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"},{"name":"National Health Commission Key Laboratory of Respiratory Diseases, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-5642","authenticated-orcid":false,"given":"Yaqi","family":"Duan","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"},{"name":"Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"},{"name":"National Health Commission Key Laboratory of Respiratory Diseases, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-8782","authenticated-orcid":false,"given":"Dongdong","family":"Zhan","sequence":"additional","affiliation":[{"name":"Beijing Pineal Diagnostics Co ., Ltd., Beijing 102206, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3222-6862","authenticated-orcid":false,"given":"Xizhen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-1570","authenticated-orcid":false,"given":"Nairen","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8002-2645","authenticated-orcid":false,"given":"Jing","family":"Cai","sequence":"additional","affiliation":[{"name":"Institution of Pathology, The First Affiliated Hospital of Henan University , Kaifeng 475001, 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China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9697-6547","authenticated-orcid":false,"given":"Zhan","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1014-1448","authenticated-orcid":false,"given":"Caixia","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4116-2597","authenticated-orcid":false,"given":"Wanlin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-9221","authenticated-orcid":false,"given":"Yuting","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"},{"name":"Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5118-6991","authenticated-orcid":false,"given":"Sailong","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"},{"name":"Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"},{"name":"National Health Commission Key Laboratory of Respiratory Diseases, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0869-3951","authenticated-orcid":false,"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"},{"name":"Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-3688","authenticated-orcid":false,"given":"Yiyun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-568X","authenticated-orcid":false,"given":"Liping","family":"Lou","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9568-0333","authenticated-orcid":false,"given":"Dong","family":"Kuang","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-7630","authenticated-orcid":false,"given":"Qian","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, 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