{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:32:53Z","timestamp":1780547573789,"version":"3.54.1"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972418"],"award-info":[{"award-number":["81972418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Provincial Science Fund for Distinguished Young Scholars","award":["2021JJ10028"],"award-info":[{"award-number":["2021JJ10028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Integrin genes are widely involved in tumorigenesis. Yet, a comprehensive characterization of integrin family members and their interactome at the pan-cancer level is lacking. Here, we systematically analyzed integrin family in approximately 10,000 tumors across 32 cancer types. Globally, integrins represent a frequently altered and misexpressed pathway, with alteration and dysregulation overall being protumorigenic. Expression dysregulation, better than mutational landscape, of integrin family successfully identifies a subgroup of aggressive tumors with a high level of proliferation and stemness. The results reveal that several molecular mechanisms collectively regulate integrin expression in a context-dependent manner. For potential clinical usage, we constructed a weighted scoring system, integrinScore, to measure integrin signaling patterns in individual tumors. Remarkably, integrinScore was consistently correlated with predefined molecular subtypes in multiple cancers, with integrinScore-high tumors being more aggressive. Importantly, integrinScore was cancer-dependent and closely associated with proliferation, stemness, tumor microenvironment, metastasis, and immune signatures. IntegrinScore also predicted patients\u2019 response to immunotherapy. By mining drug databases, we unraveled an array of compounds that may modulate integrin signaling. Finally, we built a user-friendly database, Pan-cancer Integrin Explorer (PIExplorer; http:\/\/computationalbiology.cn\/PIExplorer), to facilitate researchers to explore integrin-related knowledge. Collectively, we provide a comprehensive characterization of integrins across cancers and offer gene-specific and cancer-specific rationales for developing integrin-targeted therapy.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzae035","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T21:28:21Z","timestamp":1715290101000},"source":"Crossref","is-referenced-by-count":6,"title":["Comprehensive Characterization of the Integrin Family Across 32 Cancer Types"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-5221","authenticated-orcid":false,"given":"Cheng","family":"Zou","sequence":"first","affiliation":[{"name":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4424-9744","authenticated-orcid":false,"given":"Jinwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3803-646X","authenticated-orcid":false,"given":"Jiangling","family":"Xiong","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5408-995X","authenticated-orcid":false,"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-9506","authenticated-orcid":false,"given":"Yousong","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Biology, Hunan University , Changsha 410082,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-2833","authenticated-orcid":false,"given":"Edwin","family":"Cheung","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Macau, Macau Special Administrative Region 999078 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8505-8831","authenticated-orcid":false,"given":"Dingxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Animal Models and 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