{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:06:21Z","timestamp":1765976781525,"version":"3.44.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hematopoietic homeostasis is maintained by hematopoietic stem cells (HSCs), and it is tightly controlled at multiple levels to sustain the self-renewal capacity and differentiation potential of HSCs. Dysregulation of self-renewal and differentiation of HSCs leads to the development of hematologic diseases, including acute myeloid leukemia (AML). Thus, understanding the underlying mechanisms of HSC maintenance and the development of hematologic malignancies is one of the fundamental scientific endeavors in stem cell biology. N6-methyladenosine (m6A) is a common modification in mammalian messenger RNAs (mRNAs) and plays important roles in various biological processes. In this study, we performed a comparative analysis of the dynamics of the RNA m6A methylome of hematopoietic stem and progenitor cells (HSPCs) and leukemia-initiating cells (LICs) in AML. We found that RNA m6A modification regulates the transition of long-term HSCs into short-term HSCs and determines the lineage commitment of HSCs. Interestingly, m6A modification leads to reprogramming that promotes cellular transformation during AML development, and LIC-specific m6A targets are recognized by different m6A readers. Moreover, the very long chain fatty acid transporter ATP-binding cassette subfamily D member 2 (ABCD2) is a key factor that promotes AML development, and deletion of ABCD2 damages clonogenic ability, inhibits proliferation, and promotes apoptosis of human leukemia cells. This study provides a comprehensive understanding of the role of m6A in regulating cell state transition in normal hematopoiesis and leukemogenesis, and identifies ABCD2 as a key factor in AML development.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzae049","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T14:54:51Z","timestamp":1719240891000},"source":"Crossref","is-referenced-by-count":3,"title":["Reprogramming of RNA m6A Modification Is Required for Acute Myeloid Leukemia Development"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9678-5153","authenticated-orcid":false,"given":"Weidong","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University , Wuhan 430079,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-2724","authenticated-orcid":false,"given":"Yuhua","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University , Wuhan 430079,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0658-5705","authenticated-orcid":false,"given":"Shuxin","family":"Yao","sequence":"additional","affiliation":[{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University , Wuhan 430071,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2477-0593","authenticated-orcid":false,"given":"Guoqiang","family":"Han","sequence":"additional","affiliation":[{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University , Wuhan 430071,","place":["China"]},{"name":"Department of Hematology, Zhongnan Hospital, Medical Research Institute, Wuhan University , Wuhan 430071,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0640-3082","authenticated-orcid":false,"given":"Jin","family":"Hu","sequence":"additional","affiliation":[{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University , Wuhan 430071,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9982-4185","authenticated-orcid":false,"given":"Rong","family":"Yin","sequence":"additional","affiliation":[{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University , Wuhan 430071,","place":["China"]},{"name":"Department of Hematology, Zhongnan Hospital, Medical Research Institute, Wuhan University , Wuhan 430071,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-0382","authenticated-orcid":false,"given":"Fuling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital, Medical Research Institute, Wuhan University , Wuhan 430071,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1194-255X","authenticated-orcid":false,"given":"Ying","family":"Cheng","sequence":"additional","affiliation":[{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University , Wuhan 430071,","place":["China"]},{"name":"School of Life Sciences, Zhengzhou University , Zhengzhou 450001,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-9383","authenticated-orcid":false,"given":"Haojian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University , Wuhan 430079,","place":["China"]},{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University , Wuhan 430071,","place":["China"]},{"name":"Department of Hematology, Zhongnan Hospital, Medical Research Institute, Wuhan University , Wuhan 430071,","place":["China"]},{"name":"Taikang Center for Life and Medical Sciences, Wuhan University , Wuhan 430071,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"2025092421513449600_qzae049-B1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: an evolving paradigm for stem cell biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell"},{"key":"2025092421513449600_qzae049-B2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41576-020-0241-0","article-title":"Haematopoietic stem cell self-renewal in vivo and ex vivo","volume":"21","author":"Wilkinson","year":"2020","journal-title":"Nat Rev Genet"},{"key":"2025092421513449600_qzae049-B3","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035519","article-title":"Normal hematopoiesis is a balancing act of self-renewal and regeneration","volume":"10","author":"Olson","year":"2020","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2025092421513449600_qzae049-B4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stem.2021.09.014","article-title":"Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function","volume":"29","author":"Yin","year":"2022","journal-title":"Cell Stem Cell"},{"key":"2025092421513449600_qzae049-B5","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute myeloid leukemia","volume":"373","author":"D\u00f6hner","year":"2015","journal-title":"N Engl J Med"},{"key":"2025092421513449600_qzae049-B6","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(23)00108-3","article-title":"Acute myeloid leukaemia","volume":"401","author":"DiNardo","year":"2023","journal-title":"Lancet"},{"key":"2025092421513449600_qzae049-B7","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Cancer Genome Atlas Research Network","year":"2013","journal-title":"N Engl J Med"},{"key":"2025092421513449600_qzae049-B8","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature13038","article-title":"Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia","volume":"506","author":"Shlush","year":"2014","journal-title":"Nature"},{"key":"2025092421513449600_qzae049-B9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1182\/blood.2022017933","article-title":"Hematopoietic stem cell aging and leukemia transformation","volume":"142","author":"Colom D\u00edaz","year":"2023","journal-title":"Blood"},{"key":"2025092421513449600_qzae049-B10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature22993","article-title":"Tracing the origins of relapse in acute myeloid leukaemia to stem cells","volume":"547","author":"Shlush","year":"2017","journal-title":"Nature"},{"key":"2025092421513449600_qzae049-B11","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/nm.2415","article-title":"Stem cell gene expression programs influence clinical outcome in human leukemia","volume":"17","author":"Eppert","year":"2011","journal-title":"Nat Med"},{"key":"2025092421513449600_qzae049-B12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/BS9.0000000000000020","article-title":"Molecular mechanisms for stemness maintenance of acute myeloid leukemia stem cells","volume":"1","author":"Wang","year":"2019","journal-title":"Blood Sci"},{"key":"2025092421513449600_qzae049-B13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41568-020-0260-3","article-title":"Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis","volume":"20","author":"Yamashita","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"2025092421513449600_qzae049-B14","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","article-title":"Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells","volume":"71","author":"Desrosiers","year":"1974","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025092421513449600_qzae049-B15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"2025092421513449600_qzae049-B16","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis of mRNA methylation reveals enrichment in 3\u02b9 UTRs and near stop codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"key":"2025092421513449600_qzae049-B17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/BS9.0000000000000131","article-title":"RNA m6A modification: mapping methods, roles, and mechanisms in acute myeloid leukemia","volume":"4","author":"Yin","year":"2022","journal-title":"Blood Sci"},{"key":"2025092421513449600_qzae049-B18","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12943-023-01810-1","article-title":"Epigenetic modification of m6A regulator proteins in cancer","volume":"22","author":"Wang","year":"2023","journal-title":"Mol Cancer"},{"key":"2025092421513449600_qzae049-B19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.stem.2018.01.013","article-title":"Meddling with METTLs in normal and leukemia stem cells","volume":"22","author":"Martin","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2025092421513449600_qzae049-B20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3\u2013METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat Chem Biol"},{"key":"2025092421513449600_qzae049-B21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/cr.2014.3","article-title":"Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Res"},{"key":"2025092421513449600_qzae049-B22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature19342","article-title":"m6A RNA methylation promotes XIST-mediated transcriptional repression","volume":"537","author":"Patil","year":"2016","journal-title":"Nature"},{"key":"2025092421513449600_qzae049-B23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev-cellbio-100616-060758","article-title":"Rethinking m6A readers, writers, and erasers","volume":"33","author":"Meyer","year":"2017","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2025092421513449600_qzae049-B24","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.molcel.2018.02.015","article-title":"Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal","volume":"69","author":"Wen","year":"2018","journal-title":"Mol Cell"},{"key":"2025092421513449600_qzae049-B25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol Cell"},{"key":"2025092421513449600_qzae049-B26","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat Chem Biol"},{"key":"2025092421513449600_qzae049-B27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m6A reader YTHDC1 regulates mRNA splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Mol Cell"},{"key":"2025092421513449600_qzae049-B28","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/cr.2017.99","article-title":"Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis","volume":"27","author":"Hsu","year":"2017","journal-title":"Cell Res"},{"key":"2025092421513449600_qzae049-B29","doi-asserted-by":"crossref","first-page":"13911","DOI":"10.1093\/nar\/gku1116","article-title":"Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA","volume":"42","author":"Theler","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2025092421513449600_qzae049-B30","doi-asserted-by":"crossref","first-page":"12626","DOI":"10.1038\/ncomms12626","article-title":"YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4\u2013NOT deadenylase complex","volume":"7","author":"Du","year":"2016","journal-title":"Nat Commun"},{"key":"2025092421513449600_qzae049-B31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat Cell Biol"},{"key":"2025092421513449600_qzae049-B32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1182\/blood.2020009676","article-title":"YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner","volume":"138","author":"Feng","year":"2021","journal-title":"Blood"},{"key":"2025092421513449600_qzae049-B33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nature24678","article-title":"Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control","volume":"552","author":"Barbieri","year":"2017","journal-title":"Nature"},{"key":"2025092421513449600_qzae049-B34","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.celrep.2019.07.032","article-title":"m6A RNA methylation maintains hematopoietic stem cell identity and symmetric commitment","volume":"28","author":"Cheng","year":"2019","journal-title":"Cell Rep"},{"key":"2025092421513449600_qzae049-B35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.stem.2020.04.001","article-title":"Leukemogenic chromatin alterations promote AML leukemia stem cells via a KDM4C\u2013ALKBH5\u2013AXL signaling axis","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Stem Cell"},{"key":"2025092421513449600_qzae049-B36","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nm.4416","article-title":"The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells","volume":"23","author":"Vu","year":"2017","journal-title":"Nat Med"},{"key":"2025092421513449600_qzae049-B37","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.immuni.2020.05.003","article-title":"m6A modification prevents formation of endogenous double-stranded RNAs and deleterious innate immune responses during hematopoietic development","volume":"52","author":"Gao","year":"2020","journal-title":"Immunity"},{"key":"2025092421513449600_qzae049-B38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ccell.2020.04.017","article-title":"Targeting FTO suppresses cancer stem cell maintenance and immune evasion","volume":"38","author":"Su","year":"2020","journal-title":"Cancer Cell"},{"key":"2025092421513449600_qzae049-B39","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ccell.2016.11.017","article-title":"FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase","volume":"31","author":"Li","year":"2017","journal-title":"Cancer Cell"},{"key":"2025092421513449600_qzae049-B40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s12276-022-00735-x","article-title":"The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability","volume":"54","author":"Zhang","year":"2022","journal-title":"Exp Mol Med"},{"key":"2025092421513449600_qzae049-B41","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1158\/0008-5472.CAN-21-4249","article-title":"The RNA m6A reader YTHDF1 is required for acute myeloid leukemia progression","volume":"83","author":"Hong","year":"2023","journal-title":"Cancer Res"},{"key":"2025092421513449600_qzae049-B42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1182\/blood.2022017934","article-title":"The genesis of human hematopoietic stem cells","volume":"142","author":"Calvanese","year":"2023","journal-title":"Blood"},{"key":"2025092421513449600_qzae049-B43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.stem.2022.12.003","article-title":"Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance","volume":"30","author":"Cheng","year":"2023","journal-title":"Cell Stem Cell"},{"key":"2025092421513449600_qzae049-B44","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41556-019-0318-1","article-title":"Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation","volume":"21","author":"Lee","year":"2019","journal-title":"Nat Cell Biol"},{"key":"2025092421513449600_qzae049-B45","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ccell.2019.03.006","article-title":"Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia","volume":"35","author":"Huang","year":"2019","journal-title":"Cancer Cell"},{"key":"2025092421513449600_qzae049-B46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.stem.2019.03.021","article-title":"Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia","volume":"25","author":"Paris","year":"2019","journal-title":"Cell Stem Cell"},{"key":"2025092421513449600_qzae049-B47","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.ccell.2022.10.004","article-title":"The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia","volume":"40","author":"Weng","year":"2022","journal-title":"Cancer Cell"},{"key":"2025092421513449600_qzae049-B48","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.stem.2023.11.006","article-title":"SON is an essential m6A target for hematopoietic stem cell fate","volume":"30","author":"Luo","year":"2023","journal-title":"Cell Stem Cell"},{"key":"2025092421513449600_qzae049-B49","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.stem.2021.02.013","article-title":"Targeting energy metabolism in cancer stem cells: progress and challenges in leukemia and solid tumors","volume":"28","author":"Jones","year":"2021","journal-title":"Cell Stem Cell"},{"key":"2025092421513449600_qzae049-B50","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1182\/blood.2020008551","article-title":"Very long chain fatty acid metabolism is required in acute myeloid leukemia","volume":"137","author":"Tcheng","year":"2021","journal-title":"Blood"},{"key":"2025092421513449600_qzae049-B51","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.3390\/ijms22116093","article-title":"Peroxisomal ABC transporters: an update","volume":"22","author":"Tawbeh","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025092421513449600_qzae049-B52","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","article-title":"Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers","volume":"74","author":"Shi","year":"2019","journal-title":"Mol Cell"},{"key":"2025092421513449600_qzae049-B53","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3892\/ijo.2013.1831","article-title":"Overexpression of DICER1 induced by the upregulation of GATA1 contributes to the proliferation and apoptosis of leukemia cells","volume":"42","author":"Bai","year":"2013","journal-title":"Int J Oncol"},{"key":"2025092421513449600_qzae049-B54","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/bjh.16853","article-title":"Low-density lipoprotein receptor (LDLR) is an independent adverse prognostic factor in acute myeloid leukaemia","volume":"192","author":"Floeth","year":"2021","journal-title":"Br J Haematol"},{"key":"2025092421513449600_qzae049-B55","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s00432-018-2631-7","article-title":"Therapeutic potential of GSK-J4, a histone demethylase KDM6B\/JMJD3 inhibitor, for acute myeloid leukemia","volume":"144","author":"Li","year":"2018","journal-title":"J Cancer Res Clin Oncol"},{"key":"2025092421513449600_qzae049-B56","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2023.12.016","article-title":"Inherited blood cancer predisposition through altered transcription elongation","volume":"187","author":"Zhao","year":"2024","journal-title":"Cell"},{"key":"2025092421513449600_qzae049-B57","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1158\/2159-8290.CD-20-1459","article-title":"KAT6A and ENL form an epigenetic transcriptional control module to drive critical leukemogenic gene-expression programs","volume":"12","author":"Yan","year":"2022","journal-title":"Cancer Discov"},{"key":"2025092421513449600_qzae049-B58","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/s41375-018-0354-z","article-title":"JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis","volume":"33","author":"Lynch","year":"2019","journal-title":"Leukemia"},{"key":"2025092421513449600_qzae049-B59","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature23883","article-title":"m6A modulates haematopoietic stem and progenitor cell specification","volume":"549","author":"Zhang","year":"2017","journal-title":"Nature"},{"key":"2025092421513449600_qzae049-B60","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.cell.2017.04.018","article-title":"Vitamin A\u2013retinoic acid signaling regulates hematopoietic stem cell dormancy","volume":"169","author":"Cabezas-Wallscheid","year":"2017","journal-title":"Cell"},{"key":"2025092421513449600_qzae049-B61","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s43018-020-00126-z","article-title":"Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells","volume":"1","author":"Stevens","year":"2020","journal-title":"Nat Cancer"}],"container-title":["Genomics, Proteomics &amp; Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzae049\/58319570\/qzae049.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/article-pdf\/23\/2\/qzae049\/58319570\/qzae049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/article-pdf\/23\/2\/qzae049\/58319570\/qzae049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:51:53Z","timestamp":1758765113000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gpb\/article\/doi\/10.1093\/gpbjnl\/qzae049\/7698018"}},"subtitle":[],"editor":[{"given":"Xiangdong","family":"Fang","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5,30]]}},"URL":"https:\/\/doi.org\/10.1093\/gpbjnl\/qzae049","relation":{},"ISSN":["1672-0229","2210-3244"],"issn-type":[{"type":"print","value":"1672-0229"},{"type":"electronic","value":"2210-3244"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2024,6,24]]},"article-number":"qzae049"}}