{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:53:16Z","timestamp":1793346796949,"version":"4.5.0"},"reference-count":184,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071614"],"award-info":[{"award-number":["82071614"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101783"],"award-info":[{"award-number":["82101783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anhui Medical University School Fund","award":["2020xkj182"],"award-info":[{"award-number":["2020xkj182"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The most common epigenetic modification of messenger RNAs (mRNAs) is N6-methyladenosine (m6A), which is mainly located near the 3\u2032 untranslated region of mRNAs, near the stop codons, and within internal exons. The biological effect of m6A is dynamically modulated by methyltransferases (writers), demethylases (erasers), and m6A-binding proteins (readers). By controlling post-transcriptional gene expression, m6A has a significant impact on numerous biological functions, including RNA transcription, translation, splicing, transport, and degradation. Hence, m6A influences various physiological and pathological processes, such as spermatogenesis, oogenesis, embryogenesis, placental function, and human reproductive system diseases. During gametogenesis and embryogenesis, genetic material undergoes significant changes, including epigenomic modifications such as m6A. From spermatogenesis and oogenesis to the formation of an oosperm and early embryogenesis, m6A changes occur at every step. m6A abnormalities can lead to gamete abnormalities, developmental delays, impaired fertilization, and maternal-to-zygotic transition blockage. Both mice and humans with abnormal m6A modifications exhibit impaired fertility. In this review, we discuss the dynamic biological effects of m6A and its regulators on gamete and embryonic development and review the possible mechanisms of infertility caused by m6A changes. We also discuss the drugs currently used to manipulate m6A and provide prospects for the prevention and treatment of infertility at the epigenetic level.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzae050","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T03:29:52Z","timestamp":1719545392000},"source":"Crossref","is-referenced-by-count":20,"title":["The Role of <i>N<\/i>6-methyladenosine Modification in Gametogenesis and Embryogenesis: Impact on Fertility"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0207-0031","authenticated-orcid":false,"given":"Yujie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University , Hefei 230022,","place":["China"]},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University) , Hefei 230032,","place":["China"]},{"name":"MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University) , Hefei 230032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5768-9232","authenticated-orcid":false,"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University , Hefei 230022,","place":["China"]},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University) , Hefei 230032,","place":["China"]},{"name":"MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University) , Hefei 230032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4311-031X","authenticated-orcid":false,"given":"Hanxiao","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Protein and Plant Gene Research, School of 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, Hefei 230032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3119-1682","authenticated-orcid":false,"given":"Yue","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University , Hefei 230022,","place":["China"]},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University) , Hefei 230032,","place":["China"]},{"name":"MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University) , Hefei 230032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7814-1310","authenticated-orcid":false,"given":"Zhenran","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University , Hefei 230022,","place":["China"]},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University) , Hefei 230032,","place":["China"]},{"name":"MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University) , Hefei 230032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6548-427X","authenticated-orcid":false,"given":"Yaru","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University , Hefei 230022,","place":["China"]},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University) , Hefei 230032,","place":["China"]},{"name":"MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University) , Hefei 230032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2372-3627","authenticated-orcid":false,"given":"Zuying","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University , Hefei 230022,","place":["China"]},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University) , Hefei 230032,","place":["China"]},{"name":"MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University) , Hefei 230032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8097-052X","authenticated-orcid":false,"given":"Huifen","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University , Hefei 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Methyl-substituted nucleoside constituents and 5\u2032-terminal dinucleotide sequences in bulk poly(A)-rich RNA from imbibing wheat embryos","volume":"57","author":"Kennedy","year":"1979","journal-title":"Can J Biochem"},{"key":"2024102223075302400_qzae050-B34","first-page":"1233","article-title":"Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase","volume":"3","author":"Bokar","year":"1997","journal-title":"RNA"},{"key":"2024102223075302400_qzae050-B35","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molcel.2016.05.041","article-title":"Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases","volume":"63","author":"Wang","year":"2016","journal-title":"Mol Cell"},{"key":"2024102223075302400_qzae050-B36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nature18298","article-title":"Structural basis of N6-adenosine methylation by the METTL3\u2013METTL14 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