{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T02:50:51Z","timestamp":1773715851336,"version":"3.50.1"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFA1303200"],"award-info":[{"award-number":["2022YFA1303200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073221"],"award-info":[{"award-number":["82073221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870826"],"award-info":[{"award-number":["31870826"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073246"],"award-info":[{"award-number":["82073246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Provincial Science and Technology Project","award":["2021YFS0134"],"award-info":[{"award-number":["2021YFS0134"]}]},{"name":"National Clinical Research Center for Geriatrics of West China Hospital","award":["Z2021JC005"],"award-info":[{"award-number":["Z2021JC005"]}]},{"name":"Disciplines of Excellence of West China Hospital","award":["ZYYC23013"],"award-info":[{"award-number":["ZYYC23013"]}]},{"name":"Disciplines of Excellence of West China Hospital","award":["ZYYC23025"],"award-info":[{"award-number":["ZYYC23025"]}]},{"name":"Disciplines of Excellence of West China Hospital","award":["ZYGD20006"],"award-info":[{"award-number":["ZYGD20006"]}]},{"name":"Disciplines of Excellence of West China Hospital","award":["2016105"],"award-info":[{"award-number":["2016105"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Magnesium (Mg) deficiency is associated with increased risk and malignancy in colorectal cancer (CRC), yet the underlying mechanisms remain elusive. Here, we used genomic, proteomic, and phosphoproteomic data to elucidate the impact of Mg deficiency on CRC. Genomic analysis identified 160 genes with higher mutation frequencies in Low-Mg tumors, including key driver genes such as KMT2C and ERBB3. Unexpectedly, initiation driver genes of CRC, such as TP53 and APC, displayed higher mutation frequencies in High-Mg tumors. Additionally, proteomic and phosphoproteomic data indicated that low Mg content in tumors may activate epithelial\u2013mesenchymal transition (EMT) by modulating inflammation or remodeling the phosphoproteome of cancer cells. Notably, we observed a negative correlation between the phosphorylation of DBN1 at S142 (DBN1S142p) and Mg content. A mutation in S142 to D (DBN1S142D) mimicking DBN1S142p up-regulated MMP2 and enhanced cell migration, while treatment with MgCl2 reduced DBN1S142p, thereby reversing this phenotype. Mechanistically, Mg2+ attenuated the DBN1\u2013ACTN4 interaction by decreasing DBN1S142p, which in turn enhanced the binding of ACTN4 to F-actin and promoted F-actin polymerization, ultimately reducing MMP2 expression. These findings shed new light on the crucial role of Mg deficiency in CRC progression and suggest that Mg supplementation may be a promising preventive and therapeutic strategy for CRC.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzae053","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T14:34:12Z","timestamp":1721918052000},"source":"Crossref","is-referenced-by-count":10,"title":["Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5056-8345","authenticated-orcid":false,"given":"Rou","family":"Zhang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5113-2888","authenticated-orcid":false,"given":"Meng","family":"Hu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-1906","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1357-3629","authenticated-orcid":false,"given":"Wanmeng","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-1228","authenticated-orcid":false,"given":"Zhiqiang","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4350-4232","authenticated-orcid":false,"given":"Siyu","family":"He","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-5424","authenticated-orcid":false,"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7890-5158","authenticated-orcid":false,"given":"Yanqiu","family":"Gong","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4925-7048","authenticated-orcid":false,"given":"Xiuxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7718-4249","authenticated-orcid":false,"given":"Shan","family":"Hai","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6889-9997","authenticated-orcid":false,"given":"Shuangqing","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7589-8877","authenticated-orcid":false,"given":"Shiqian","family":"Qi","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0274-855X","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Digestive Surgery, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-1531","authenticated-orcid":false,"given":"Yang","family":"Shu","sequence":"additional","affiliation":[{"name":"Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-8197","authenticated-orcid":false,"given":"Dan","family":"Du","sequence":"additional","affiliation":[{"name":"Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-2462","authenticated-orcid":false,"given":"Huiyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7748-2621","authenticated-orcid":false,"given":"Heng","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7616-1199","authenticated-orcid":false,"given":"Zongguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Digestive Surgery, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]},{"name":"Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5652-1962","authenticated-orcid":false,"given":"Peng","family":"Lei","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-8498","authenticated-orcid":false,"given":"Hai-Ning","family":"Chen","sequence":"additional","affiliation":[{"name":"Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-8910","authenticated-orcid":false,"given":"Lunzhi","family":"Dai","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics and General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"2024102223081281600_qzae053-B1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"2024102223081281600_qzae053-B2","doi-asserted-by":"crossref","first-page":"110173","DOI":"10.1016\/j.cbi.2022.110173","article-title":"Essential metals in health and disease","volume":"367","author":"Jomova","year":"2022","journal-title":"Chem Biol Interact"},{"key":"2024102223081281600_qzae053-B3","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cell.2020.08.049","article-title":"Lactate elicits ER-mitochondrial Mg2+ dynamics to integrate cellular metabolism","volume":"183","author":"Daw","year":"2020","journal-title":"Cell"},{"key":"2024102223081281600_qzae053-B4","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/nar\/gkp024","article-title":"Effects of magnesium and related divalent metal ions in topoisomerase structure and function","volume":"37","author":"Sissi","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2024102223081281600_qzae053-B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00012.2014","article-title":"Magnesium in man: implications for health and disease","volume":"95","author":"de Baaij","year":"2015","journal-title":"Physiol Rev"},{"key":"2024102223081281600_qzae053-B6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0092-8674(00)80717-5","article-title":"Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair","volume":"97","author":"Ban","year":"1999","journal-title":"Cell"},{"key":"2024102223081281600_qzae053-B7","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1073\/pnas.72.9.3551","article-title":"Central role for magnesium in coordinate control of metabolism and growth in animal cells","volume":"72","author":"Rubin","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024102223081281600_qzae053-B8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3390\/nu13020463","article-title":"Magnesium in aging, health and diseases","volume":"13","author":"Barbagallo","year":"2021","journal-title":"Nutrients"},{"key":"2024102223081281600_qzae053-B9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3390\/nu13010210","article-title":"Mg2+ transporters in digestive cancers","volume":"13","author":"Auwercx","year":"2021","journal-title":"Nutrients"},{"key":"2024102223081281600_qzae053-B10","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1007\/s12253-019-00750-w","article-title":"Potential role of magnesium in cancer initiation and progression","volume":"26","author":"Gupta","year":"2020","journal-title":"Pathol Oncol Res"},{"key":"2024102223081281600_qzae053-B11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1684\/mrh.2020.0470","article-title":"Magnesium deficiency with high calcium-to-magnesium ratio promotes a metastatic phenotype in the CT26 colon cancer cell line","volume":"33","author":"Kumar","year":"2020","journal-title":"Magnes Res"},{"key":"2024102223081281600_qzae053-B12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbadis.2004.08.003","article-title":"Magnesium deficiency inhibits primary tumor growth but favors metastasis in mice","volume":"1739","author":"Nasulewicz","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"2024102223081281600_qzae053-B13","doi-asserted-by":"crossref","first-page":"589112","DOI":"10.3389\/fonc.2020.589112","article-title":"Magnesium in combinatorial with valproic acid suppressed the proliferation and migration of human bladder cancer cells","volume":"10","author":"Li","year":"2020","journal-title":"Front Oncol"},{"key":"2024102223081281600_qzae053-B14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.abb.2006.03.031","article-title":"Magnesium and the inflammatory response: potential physiopathological implications","volume":"458","author":"Mazur","year":"2007","journal-title":"Arch Biochem Biophys"},{"key":"2024102223081281600_qzae053-B15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/rb\/rbaa010","article-title":"In vitro immunomodulation of magnesium on monocytic cell toward anti-inflammatory macrophages","volume":"7","author":"Sun","year":"2020","journal-title":"Regen Biomater"},{"key":"2024102223081281600_qzae053-B16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/bjc.1986.147","article-title":"Effects of magnesium supplementation in testicular cancer patients receiving cis-platin: a randomised trial","volume":"54","author":"Willox","year":"1986","journal-title":"Br J Cancer"},{"key":"2024102223081281600_qzae053-B17","doi-asserted-by":"crossref","first-page":"16538","DOI":"10.1038\/srep16538","article-title":"Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin","volume":"5","author":"Castiglioni","year":"2015","journal-title":"Sci Rep"},{"key":"2024102223081281600_qzae053-B18","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s12011-018-1474-z","article-title":"Dietary intakes of calcium, Iron, magnesium, and potassium elements and the risk of colorectal cancer: a meta-analysis","volume":"189","author":"Meng","year":"2019","journal-title":"Biol Trace Elem Res"},{"key":"2024102223081281600_qzae053-B19","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/ejcn.2012.135","article-title":"Magnesium intake and risk of colorectal cancer: a meta-analysis of prospective studies","volume":"66","author":"Chen","year":"2012","journal-title":"Eur J Clin Nutr"},{"key":"2024102223081281600_qzae053-B20","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/sj.bjc.6603577","article-title":"Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study","volume":"96","author":"van den Brandt","year":"2007","journal-title":"Br J Cancer"},{"key":"2024102223081281600_qzae053-B21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1001\/jama.293.1.86","article-title":"Magnesium intake in relation to risk of colorectal cancer in women","volume":"293","author":"Larsson","year":"2005","journal-title":"JAMA"},{"key":"2024102223081281600_qzae053-B22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s10787-019-00603-7","article-title":"The role of magnesium in different inflammatory diseases","volume":"27","author":"Shahi","year":"2019","journal-title":"Inflammopharmacology"},{"key":"2024102223081281600_qzae053-B23","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.3390\/nu14091914","article-title":"Magnesium\u2014a potential key player in inflammatory bowel diseases?","volume":"14","author":"Gilca-Blanariu","year":"2022","journal-title":"Nutrients"},{"key":"2024102223081281600_qzae053-B24","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41577-021-00534-x","article-title":"The inflammatory pathogenesis of colorectal cancer","volume":"21","author":"Schmitt","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"2024102223081281600_qzae053-B25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11010-007-9554-y","article-title":"Intestinal inflammation caused by magnesium deficiency alters basal and oxidative stress-induced intestinal function","volume":"306","author":"Scanlan","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"2024102223081281600_qzae053-B26","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3390\/antiox9100907","article-title":"Magnesium, oxidative stress, inflammation, and cardiovascular disease","volume":"9","author":"Liu","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"2024102223081281600_qzae053-B27","doi-asserted-by":"crossref","first-page":"2019643","DOI":"10.1155\/2016\/2019643","article-title":"Magnesium supplementation diminishes peripheral blood lymphocyte DNA oxidative damage in athletes and sedentary young man","volume":"2016","author":"Petrovi\u0107","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"2024102223081281600_qzae053-B28","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3390\/nu10040398","article-title":"Dietary intake of magnesium or calcium and chemotherapy-induced peripheral neuropathy in colorectal cancer patients","volume":"10","author":"Wesselink","year":"2018","journal-title":"Nutrients"},{"key":"2024102223081281600_qzae053-B29","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"2024102223081281600_qzae053-B30","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1073\/pnas.1815361116","article-title":"Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism","volume":"116","author":"Hardy","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024102223081281600_qzae053-B31","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.3390\/ijms20081877","article-title":"TRPM7, magnesium, and signaling","volume":"20","author":"Zou","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2024102223081281600_qzae053-B32","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/08927022.2011.561430","article-title":"Role of Mg2+\u00a0ions in protein kinase phosphorylation: insights from molecular dynamics simulations of ATP-kinase complexes","volume":"37","author":"Yu","year":"2011","journal-title":"Mol Simulat"},{"key":"2024102223081281600_qzae053-B33","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.cell.2019.03.030","article-title":"Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities","volume":"177","author":"Vasaikar","year":"2019","journal-title":"Cell"},{"key":"2024102223081281600_qzae053-B34","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.ccell.2020.08.002","article-title":"Integrated omics of metastatic colorectal cancer","volume":"38","author":"Li","year":"2020","journal-title":"Cancer Cell"},{"key":"2024102223081281600_qzae053-B35","doi-asserted-by":"crossref","first-page":"100532","DOI":"10.1016\/j.mcpro.2023.100532","article-title":"Phenotypic heterogeneity analysis of APC-mutant colon cancer by proteomics and phosphoproteomics identifies RAI14 as a key prognostic determinant in East Asians and Westerners","volume":"22","author":"Zhang","year":"2023","journal-title":"Mol Cell Proteomics"},{"key":"2024102223081281600_qzae053-B36","doi-asserted-by":"crossref","first-page":"100545","DOI":"10.1016\/j.mcpro.2023.100545","article-title":"Deciphering the clinical significance and kinase functions of GSK3\u03b1 in colon cancer by proteomics and phosphoproteomics","volume":"22","author":"Gao","year":"2023","journal-title":"Mol Cell Proteomics"},{"key":"2024102223081281600_qzae053-B37","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41467-022-28060-x","article-title":"The mouse metallomic landscape of aging and metabolism","volume":"13","author":"Morel","year":"2022","journal-title":"Nat Commun"},{"key":"2024102223081281600_qzae053-B38","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.cell.2017.09.048","article-title":"Comprehensive analysis of hypermutation in human cancer","volume":"171","author":"Campbell","year":"2017","journal-title":"Cell"},{"key":"2024102223081281600_qzae053-B39","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/34693","article-title":"Visualizing DNA replication in a catalytically active\u00a0Bacillus\u00a0DNA polymerase crystal","volume":"391","author":"Kiefer","year":"1998","journal-title":"Nature"},{"key":"2024102223081281600_qzae053-B40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/34593","article-title":"Crystal structure of a bacteriophage T7 DNA replication complex at 2.2\u2009\u00c5 resolution","volume":"391","author":"Doubli\u00e9","year":"1998","journal-title":"Nature"},{"key":"2024102223081281600_qzae053-B41","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"Cancer Genome Atlas Network","year":"2012","journal-title":"Nature"},{"key":"2024102223081281600_qzae053-B42","first-page":"165","article-title":"Magnesium: its role in nutrition and carcinogenesis","volume":"64","author":"Blaszczyk","year":"2013","journal-title":"Rocz Panstw Zakl Hig"},{"key":"2024102223081281600_qzae053-B43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0027-5107(01)00074-4","article-title":"Role of magnesium in genomic stability","volume":"475","author":"Hartwig","year":"2001","journal-title":"Mutat Res"},{"key":"2024102223081281600_qzae053-B44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.abb.2006.02.016","article-title":"Magnesium and neoplasia: from carcinogenesis to tumor growth and progression or treatment","volume":"458","author":"Wolf","year":"2007","journal-title":"Arch Biochem Biophys"},{"key":"2024102223081281600_qzae053-B45","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41568-020-0290-x","article-title":"A compendium of mutational cancer driver genes","volume":"20","author":"Mart\u00ednez-Jim\u00e9nez","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"2024102223081281600_qzae053-B46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/cells10010067","article-title":"Association between inflammation and function of cell adhesion molecules influence on gastrointestinal cancer development","volume":"10","author":"Huang","year":"2021","journal-title":"Cells"},{"key":"2024102223081281600_qzae053-B47","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1161\/ATVBAHA.116.307610","article-title":"Endothelial cell junctional adhesion molecules: role and regulation of expression in inflammation","volume":"36","author":"Reglero-Real","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024102223081281600_qzae053-B48","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nri2096","article-title":"The role of junctional adhesion molecules in vascular inflammation","volume":"7","author":"Weber","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"2024102223081281600_qzae053-B49","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2021.12.039","article-title":"Magnesium sensing via LFA-1 regulates CD8+ T cell effector function","volume":"185","author":"L\u00f6tscher","year":"2022","journal-title":"Cell"},{"key":"2024102223081281600_qzae053-B50","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41568-019-0210-0","article-title":"Context-dependent roles of complement in cancer","volume":"19","author":"Roumenina","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"2024102223081281600_qzae053-B51","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41577-019-0168-x","article-title":"New insights into the immune functions of complement","volume":"19","author":"Reis","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"2024102223081281600_qzae053-B52","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3892\/or.2014.3341","article-title":"Cancer cells release anaphylatoxin C5a from C5 by serine protease to enhance invasiveness","volume":"32","author":"Nitta","year":"2014","journal-title":"Oncol Rep"},{"key":"2024102223081281600_qzae053-B53","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.4049\/jimmunol.1501886","article-title":"Complement component 3 is regulated by TWIST1 and mediates epithelial\u2013mesenchymal transition","volume":"196","author":"Cho","year":"2016","journal-title":"J Immunol"},{"key":"2024102223081281600_qzae053-B54","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/leu.2016.198","article-title":"Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1","volume":"31","author":"Abdelbaset-Ismail","year":"2017","journal-title":"Leukemia"},{"key":"2024102223081281600_qzae053-B55","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrm1199","article-title":"Phosphatases in cell-matrix adhesion and migration","volume":"4","author":"Larsen","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2024102223081281600_qzae053-B56","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal adhesion kinase: in command and control of cell motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2024102223081281600_qzae053-B57","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1038\/ncomms8523","article-title":"Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction","volume":"6","author":"Butkevich","year":"2015","journal-title":"Nat Commun"},{"key":"2024102223081281600_qzae053-B58","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.yexcr.2012.03.007","article-title":"MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype","volume":"318","author":"Howard","year":"2012","journal-title":"Exp Cell Res"},{"key":"2024102223081281600_qzae053-B59","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/hep.30930","article-title":"PDLIM1 inhibits tumor metastasis through activating Hippo signaling in hepatocellular carcinoma","volume":"71","author":"Huang","year":"2020","journal-title":"Hepatology"},{"key":"2024102223081281600_qzae053-B60","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ctrv.2009.01.003","article-title":"Magnesium and tumors: ally or foe?","volume":"35","author":"Wolf","year":"2009","journal-title":"Cancer Treat Rev"},{"key":"2024102223081281600_qzae053-B61","doi-asserted-by":"crossref","first-page":"102078","DOI":"10.1016\/j.ceca.2019.102078","article-title":"Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks","volume":"83","author":"Trapani","year":"2019","journal-title":"Cell Calcium"},{"key":"2024102223081281600_qzae053-B62","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/cmi.2015.93","article-title":"Magnesium ion influx reduces neuroinflammation in A\u03b2 precursor protein\/presenilin 1 transgenic mice by suppressing the expression of interleukin-1\u03b2","volume":"14","author":"Wang","year":"2017","journal-title":"Cell Mol Immunol"},{"key":"2024102223081281600_qzae053-B63","doi-asserted-by":"crossref","first-page":"20681","DOI":"10.1073\/pnas.2003771117","article-title":"Mathematical model of colorectal cancer initiation","volume":"117","author":"Paterson","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024102223081281600_qzae053-B64","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1002\/mco2.144","article-title":"Epithelial\u2013mesenchymal transition: the history, regulatory mechanism, and cancer therapeutic opportunities","volume":"3","author":"Huang","year":"2022","journal-title":"MedComm"},{"key":"2024102223081281600_qzae053-B65","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12943-016-0502-x","article-title":"Regulation of epithelial\u2013mesenchymal transition through epigenetic and post-translational modifications","volume":"15","author":"Serrano-Gomez","year":"2016","journal-title":"Mol Cancer"},{"key":"2024102223081281600_qzae053-B66","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1002\/mco2.261","article-title":"Protein posttranslational modifications in health and diseases: functions, regulatory mechanisms, and therapeutic implications","volume":"4","author":"Zhong","year":"2023","journal-title":"MedComm (2020)"},{"key":"2024102223081281600_qzae053-B67","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ccr.2014.07.022","article-title":"PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial\u2013mesenchymal transition and metastasis","volume":"26","author":"Zheng","year":"2014","journal-title":"Cancer Cell"},{"key":"2024102223081281600_qzae053-B68","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/ncb1173","article-title":"Dual regulation of Snail by GSK-3\u03b2-mediated phosphorylation in control of epithelial\u2013mesenchymal transition","volume":"6","author":"Zhou","year":"2004","journal-title":"Nat Cell Biol"},{"key":"2024102223081281600_qzae053-B69","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/hep.27911","article-title":"Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial\u2013mesenchymal transition","volume":"62","author":"Wang","year":"2015","journal-title":"Hepatology"},{"key":"2024102223081281600_qzae053-B70","doi-asserted-by":"crossref","first-page":"15184","DOI":"10.1038\/s41598-021-94509-6","article-title":"Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients","volume":"11","author":"Parisse","year":"2021","journal-title":"Sci Rep"},{"key":"2024102223081281600_qzae053-B71","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/ajcn\/nqaa049","article-title":"Vitamin D, magnesium, calcium, and their interaction in relation to colorectal cancer recurrence and all-cause mortality","volume":"111","author":"Wesselink","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"2024102223081281600_qzae053-B72","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1158\/1078-0432.CCR-08-0077","article-title":"Early magnesium reduction in advanced colorectal cancer patients treated with cetuximab plus irinotecan as predictive factor of efficacy and outcome","volume":"14","author":"Vincenzi","year":"2008","journal-title":"Clin Cancer Res"},{"key":"2024102223081281600_qzae053-B73","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1097\/CAD.0000000000000965","article-title":"Predictive and prognostic value of magnesium serum level in FOLFIRI plus cetuximab or bevacizumab treated patients with stage IV colorectal cancer: results from the FIRE-3 (AIO KRK-0306) study","volume":"31","author":"Schulz","year":"2020","journal-title":"Anticancer Drugs"},{"key":"2024102223081281600_qzae053-B74","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.3892\/ol.2015.3800","article-title":"Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature","volume":"10","author":"Streb","year":"2015","journal-title":"Oncol Lett"},{"key":"2024102223081281600_qzae053-B75","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1470-2045(07)70108-0","article-title":"Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study","volume":"8","author":"Tejpar","year":"2007","journal-title":"Lancet Oncol"},{"key":"2024102223081281600_qzae053-B76","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.10.013","article-title":"Extracellular matrix component signaling in cancer","volume":"97","author":"Multhaupt","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"2024102223081281600_qzae053-B77","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41392-021-00544-0","article-title":"Extracellular matrix and its therapeutic potential for cancer treatment","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"2024102223081281600_qzae053-B78","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/j.apsb.2021.01.004","article-title":"Integrins as attractive targets for cancer therapeutics","volume":"11","author":"Li","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"2024102223081281600_qzae053-B79","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1186\/gb-2011-12-4-r41","article-title":"GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers","volume":"12","author":"Mermel","year":"2011","journal-title":"Genome Biol"},{"key":"2024102223081281600_qzae053-B80","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2024102223081281600_qzae053-B81","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"2024102223081281600_qzae053-B82","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"key":"2024102223081281600_qzae053-B83","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.gpb.2021.08.001","article-title":"The Genome Sequence Archive Family: toward explosive data growth and diverse data types","volume":"19","author":"Chen","year":"2021","journal-title":"Genomics Proteomics Bioinformatics"}],"container-title":["Genomics, Proteomics &amp; Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/gpb\/advance-article-pdf\/doi\/10.1093\/gpbjnl\/qzae053\/58652134\/qzae053.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/article-pdf\/22\/4\/qzae053\/59972947\/qzae053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/article-pdf\/22\/4\/qzae053\/59972947\/qzae053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T19:11:04Z","timestamp":1729624264000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gpb\/article\/doi\/10.1093\/gpbjnl\/qzae053\/7720982"}},"subtitle":[],"editor":[{"given":"Tiannan","family":"Guo","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":83,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/gpbjnl\/qzae053","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.01.22.576593","asserted-by":"object"}]},"ISSN":["1672-0229","2210-3244"],"issn-type":[{"value":"1672-0229","type":"print"},{"value":"2210-3244","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,7,25]]},"article-number":"qzae053"}}