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This method circumvents biases intrinsic to amplification-based approaches, enabling thorough analysis of complex genomic regions [including tandem repeats, segmental duplications, ribosomal DNA (rDNA) arrays, and centromeres] as well as direct detection of base modifications, furnishing both sequence and epigenetic data concurrently. This has streamlined a number of tasks including genome assembly, variant detection, and full-length transcript analysis. This review provides a comprehensive overview of the applications and challenges of HiFi sequencing across various fields, including genomics, transcriptomics, and epigenetics. By delineating the evolving landscape of HiFi sequencing in multi-omics research, we highlight its potential to deepen our understanding of genetic mechanisms and to advance precision medicine.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzaf003","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T12:34:05Z","timestamp":1738931645000},"source":"Crossref","is-referenced-by-count":17,"title":["Long and Accurate: How HiFi Sequencing is Transforming Genomics"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-878X","authenticated-orcid":false,"given":"Bo","family":"Wang","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-919X","authenticated-orcid":false,"given":"Peng","family":"Jia","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3810-6527","authenticated-orcid":false,"given":"Shenghan","family":"Gao","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8641-6487","authenticated-orcid":false,"given":"Huanhuan","family":"Zhao","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-5481","authenticated-orcid":false,"given":"Gaoyang","family":"Zheng","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6386-1815","authenticated-orcid":false,"given":"Linfeng","family":"Xu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-6741","authenticated-orcid":false,"given":"Kai","family":"Ye","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"2025121705423831200_qzaf003-B1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.cell.2019.02.032","article-title":"Genomic 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