{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:57:45Z","timestamp":1770839865322,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Transcriptome-wide association study (TWAS) is a powerful approach for investigating the molecular mechanisms linking genetic loci to complex phenotypes. However, the complexity of the TWAS analytical pipeline, including the construction of gene expression reference panels, gene expression prediction, and association analysis using data from genome-wide association studies (GWASs), poses challenges for genetic studies in many species. In this study, we provide the Farm Animal Genotype-Tissue Expression (FarmGTEx) TWAS-server, an interactive and user-friendly multispecies platform designed to streamline the translation of genetic findings across tissues and species. The server incorporates gene expression data from 49 human tissues (838 individuals), 34 pig tissues (5457 individuals), and 23 cattle tissues (4889 individuals), providing prediction models for 38,180 human genes, 21,037 pig genes, and 17,942 cattle genes. It supports genotype-based gene expression prediction, GWAS summary statistics imputation, customizable TWAS analysis, functional annotation, and result visualization. Additionally, we provide 479,203, 1208, and 657 tissue\u2013gene\u2013trait associations for 1129 human traits, 41 cattle traits, and 11 pig traits, respectively. Utilizing the TWAS-server, we validated the association of the ABCD4 gene with pig teat number. Furthermore, we identified that pig backfat thickness may share genetic similarities with human diastolic blood pressure, sarcoidosis (L\u00f6fgren syndrome), and body mass index. The FarmGTEx TWAS-server offers a comprehensive and accessible platform for researchers to perform TWAS analyses across tissues and species. It is freely available at https:\/\/twas.farmgtex.org, with regular updates planned as the FarmGTEx project expands to include more species.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzaf006","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T13:05:01Z","timestamp":1739279101000},"source":"Crossref","is-referenced-by-count":10,"title":["FarmGTEx TWAS-server: An Interactive Web Server for Customized TWAS Analysis"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1987-2259","authenticated-orcid":false,"given":"Zhenyang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Animal Science, College of Animal Sciences, Zhejiang University , Hangzhou 310058,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-0810","authenticated-orcid":false,"given":"Zitao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Sciences, Zhejiang University , Hangzhou 310058,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3046-1452","authenticated-orcid":false,"given":"Jinyan","family":"Teng","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University , Guangzhou 510642,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8379-4994","authenticated-orcid":false,"given":"Shuli","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Westlake University , Hangzhou 310024,","place":["China"]},{"name":"Westlake Laboratory of Life Sciences and Biomedicine , Hangzhou 310030,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8416-9748","authenticated-orcid":false,"given":"Qing","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University , Guangzhou 510642,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5537-6804","authenticated-orcid":false,"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University , Guangzhou 510642,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0602-4823","authenticated-orcid":false,"given":"Yahui","family":"Gao","sequence":"additional","affiliation":[{"name":"Animal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA , Beltsville, MD 20705,","place":["USA"]},{"name":"Department of Animal and Avian Sciences, University of Maryland , College Park, Baltimore, MD 20742,","place":["USA"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8697-1813","authenticated-orcid":false,"given":"Zhonghao","family":"Bai","sequence":"additional","affiliation":[{"name":"Center for Quantitative Genetics and Genomics, Aarhus University , Aarhus 8000,","place":["Denmark"]}]},{"name":"FarmGTEx Consortium","sequence":"additional","affiliation":[]},{"given":"Lingzhao","family":"Fang","sequence":"additional","affiliation":[]},{"given":"Zhonghao","family":"Bai","sequence":"additional","affiliation":[]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Jinyan","family":"Teng","sequence":"additional","affiliation":[]},{"given":"Qing","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Zhenyang","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Zitao","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Qishan","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Yuchun","family":"Pan","sequence":"additional","affiliation":[]},{"given":"Shuli","family":"Liu","sequence":"additional","affiliation":[]},{"given":"George","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Yahui","family":"Gao","sequence":"additional","affiliation":[]},{"given":"Bingjie","family":"Li","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8528-1889","authenticated-orcid":false,"given":"Bingjie","family":"Li","sequence":"additional","affiliation":[{"name":"Scotland's Rural College (SRUC), Roslin Institute Building , Midlothian, EH25 9RG,","place":["UK"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-6705","authenticated-orcid":false,"given":"George","family":"Liu","sequence":"additional","affiliation":[{"name":"Animal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA , Beltsville, MD 20705,","place":["USA"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-3125","authenticated-orcid":false,"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Sciences, Zhejiang University , Hangzhou 310058,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1163-5963","authenticated-orcid":false,"given":"Yuchun","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Sciences, Zhejiang University , Hangzhou 310058,","place":["China"]},{"name":"Hainan Institute, Zhejiang University, Yongyou Industrial Park, Yazhou Bay Sci-Tech City , Sanya 572000,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7338-7718","authenticated-orcid":false,"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University , Guangzhou 510642,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1103-3679","authenticated-orcid":false,"given":"Lingzhao","family":"Fang","sequence":"additional","affiliation":[{"name":"Center for Quantitative Genetics and Genomics, Aarhus University , Aarhus 8000,","place":["Denmark"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6475-0009","authenticated-orcid":false,"given":"Qishan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Sciences, Zhejiang University , Hangzhou 310058,","place":["China"]},{"name":"Hainan Institute, Zhejiang University, Yongyou Industrial Park, Yazhou Bay Sci-Tech City , Sanya 572000,","place":["China"]},{"name":"Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of 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