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In this study, we conducted genome-wide profiling of histone H3 lysine 18 lactylation (H3K18la) in T-cell acute lymphoblastic leukemia (T-ALL). We observed elevated\u00a0lactate and H3K18la levels in T-ALL cells compared to normal T cells, with H3K18la levels positively associated with cell proliferation. Accordingly, we observed a significant shift in genome-wide H3K18la modifications from T cell immunity in normal T cells to leukemogenesis in T-ALL, correlated with altered gene transcription profiles. We showed that H3K18la primarily functions in active transcriptional regulation and observed clusters of H3K18la modifications resembling\u00a0super-enhancers. Disrupting H3K18la modification revealed both synergistic and divergent changes between H3K18la and histone H3 lysine 27 acetylation (H3K27ac) modifications. Finally, we found that the high transcription of H3K18la target genes, IGFBP2 and IARS, is associated with inferior prognosis of T-ALL. These findings enhance our understanding of how metabolic disruptions contribute to transcription dysregulation through epigenetic changes in T-ALL, underscoring the interplay of histone modifications in maintaining oncogenic epigenetic stability.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzaf029","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T22:43:29Z","timestamp":1744065809000},"source":"Crossref","is-referenced-by-count":9,"title":["Glycolysis Induces Abnormal Transcription Through Histone Lactylation in T-cell Acute Lymphoblastic Leukemia"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8097-3483","authenticated-orcid":false,"given":"Wenyan","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Hematology & Oncology, Pediatric Translational Medicine Institute, Shanghai Children\u2019s Medical Center, School of Medicine, 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