{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:06:10Z","timestamp":1772183170413,"version":"3.50.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High-quality genome databases derived from large-scale, family-based birth cohorts are vital resources for investigating the genetic determinants of early-life traits and the impact of early-life environments on the health of both parents and offspring. Here, we established a genomic platform for the Born in Guangzhou Cohort Study (BIGCS), the Genome Database of BIGCS (GDBIG), which represents the first birth cohort-based genomic database in China and is designed to facilitate intergenerational genetic research. Based on the phase I results of the BIGCS, GDBIG includes low-coverage (\u223c 6.63\u00d7) whole-genome sequencing (WGS) data and extensive pregnancy phenotypes from 4053 Chinese participants. These participants are from 30 of China\u2019s 34 provincial-level administrative divisions, encompassing Han and 12 minority ethnic groups. Currently, GDBIG provides a range of services, including allele frequency queries for 56.23 million variants across two generations, a genotype imputation server featuring a high-quality family-based reference panel, and a genome-wide association study (GWAS) meta-analysis interface for various maternal and infant phenotypes. The GDBIG database addresses the lack of Asian birth cohort-based genomic resources and provides a valuable platform for conducting genetic analysis, accessible online or via application programming interfaces at http:\/\/gdbig.bigcs.com.cn\/.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzaf045","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T11:11:56Z","timestamp":1747307516000},"source":"Crossref","is-referenced-by-count":1,"title":["GDBIG: A Pioneering Birth Cohort Genomic Platform Facilitating Intergenerational Genetic Research"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-2534","authenticated-orcid":false,"given":"Shujia","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou 510623,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-0595","authenticated-orcid":false,"given":"Chengrui","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou 510623,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-5880","authenticated-orcid":false,"given":"Mingxi","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou 510623,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-8628","authenticated-orcid":false,"given":"Jinhua","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou 510623,","place":["China"]},{"name":"Provincial Clinical Research Center for Child Health , Guangzhou 510623,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-5126","authenticated-orcid":false,"given":"Jian-Rong","family":"He","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou 510623,","place":["China"]},{"name":"Provincial Clinical Research Center for Child Health , Guangzhou 510623,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou 510623,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-6195","authenticated-orcid":false,"given":"Shanshan","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou 510623,","place":["China"]},{"name":"Department of Women\u2019s Health, Provincial Key Clinical Specialty of Woman and Child Health, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou 510623,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6780-9419","authenticated-orcid":false,"given":"Siyang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University , Shenzhen 518107,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-3583","authenticated-orcid":false,"given":"Huimin","family":"Xia","sequence":"additional","affiliation":[{"name":"Provincial Clinical Research Center for Child Health , Guangzhou 510623,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou 510623,","place":["China"]},{"name":"Department of Pediatric Surgery, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou 510623,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-229X","authenticated-orcid":false,"given":"Xiu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study, Guangzhou Women and Children\u2019s Medical 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