{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T01:24:22Z","timestamp":1774229062166,"version":"3.50.1"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Subjective cognitive decline (SCD) is widely regarded as a potential preclinical stage of Alzheimer\u2019s disease (AD), yet its genetic basis remains poorly understood. To address this gap, we investigated genetic biomarkers associated with SCD using whole-genome sequencing (WGS) in 10,763 Chinese participants from the Healthy Zhejiang One Million People Cohort (HOPE Cohort). The discovery stage included 9284 samples, with 1479 samples used for validation. Using a two-stage design, we systematically investigated both common and rare variants associated with SCD. In rare variant analyses, we identified and replicated an association between the upstream region of SEPHS2 and SCD. SEPHS2 is involved in selenophosphate synthesis, and a Mendelian randomization analysis reveals that its expression levels in both blood and brain cerebellum are associated with AD. Additionally, we identified CLVS2, which encodes a protein primarily expressed in neuronal cells, as a potential regulator for SCD based on missense rare variants. Multi-omics evidence suggests that both SEPHS2 and CLVS2 may play roles in neurodegenerative diseases. For common variants, we validated 8 known loci related to cognitive decline, 3 of which originated from the only existing SCD genetic study conducted under a migraine background. Overall, our WGS-based study fills the gap in SCD research by providing vital genetic evidence from an East Asian population and offers insights into the pathogenic mechanisms of SCD.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzaf063","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T16:35:12Z","timestamp":1753806912000},"source":"Crossref","is-referenced-by-count":2,"title":["Whole-genome Sequence Analysis Revealed Novel Subjective Cognitive Decline-associated Genes in 10,763 Chinese"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5127-5491","authenticated-orcid":false,"given":"Mengying","family":"Wang","sequence":"first","affiliation":[{"name":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","place":["China"]},{"name":"Department of Nutrition, Child, and Adolescent Health, School of Public Health, Hangzhou Medical College , Hangzhou 310007,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3668-7192","authenticated-orcid":false,"given":"Liyang","family":"Sun","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Zhejiang University School of Medicine, Lanxi Branch (Lanxi People\u2019s Hospital) , Lanxi 321100,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-6480","authenticated-orcid":false,"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1637-0318","authenticated-orcid":false,"given":"Ruoqi","family":"Dai","sequence":"additional","affiliation":[{"name":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8115-1482","authenticated-orcid":false,"given":"Qilong","family":"Tan","sequence":"additional","affiliation":[{"name":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-3891","authenticated-orcid":false,"given":"Yun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8466-1074","authenticated-orcid":false,"given":"Andi","family":"Xu","sequence":"additional","affiliation":[{"name":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9749-2178","authenticated-orcid":false,"given":"Weifang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Lanxi Hospital of Traditional Chinese Medicine , Lanxi 321100,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5259-4643","authenticated-orcid":false,"given":"Yuanxing","family":"Tu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Zhejiang University School of Medicine, Lanxi Branch (Lanxi People\u2019s Hospital) , Lanxi 321100,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5313-8164","authenticated-orcid":false,"given":"Dan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6196-9964","authenticated-orcid":false,"given":"Wenyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-8129","authenticated-orcid":false,"given":"Xifeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","place":["China"]},{"name":"Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou 310058,","place":["China"]},{"name":"National Institute for Data Science in Health and Medicine, Zhejiang University , Hangzhou 310058,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"2026022615561936400_qzaf063-B1","volume-title":"World Alzheimer Report 2018 \u2014 the state of the art of dementia research: new frontiers","author":"Alzheimer\u2019s Disease International, Patterson C","year":"2018"},{"key":"2026022615561936400_qzaf063-B2","doi-asserted-by":"crossref","first-page":"h3029","DOI":"10.1136\/bmj.h3029","article-title":"Dementia: timely diagnosis and early intervention","volume":"350","author":"Robinson","year":"2015","journal-title":"BMJ"},{"key":"2026022615561936400_qzaf063-B3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fneur.2020.00247","article-title":"Subjective cognitive decline and related cognitive deficits","volume":"11","author":"Si","year":"2020","journal-title":"Front 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