{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:48:41Z","timestamp":1775551721105,"version":"3.50.1"},"reference-count":115,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Body weight is a polygenic trait with intricate inheritance patterns. Functional genomics enriched with multi-layer annotations offers essential resources for exploring the genetic architecture of complex traits. In this study, we conducted an extensive characterization of regulatory variants associated with body weight-related traits in cattle using multi-omics analysis. First, we identified seven candidate genes by integrating selective sweep analysis and multiple genome-wide association study (GWAS) strategies using imputed whole-genome sequencing data from a population of 1577 individuals. Subsequently, we uncovered 3340 eGenes (genes whose expression levels are associated with genetic variants) across 227 muscle samples. Transcriptome-wide association studies (TWASs) further revealed a total of 532 distinct candidate genes associated with body weight-related traits. Colocalization analyses unveiled 44 genes shared between expression quantitative trait loci (eQTLs) and GWAS signals. Moreover, a comprehensive analysis by integrating GWAS, selective sweep, eQTL, TWAS, epigenomic profiling, and molecular validation highlighted a positively selected genomic region on Bos taurus autosome 6 (BTA6). This locus harbors pleiotropic genes (LAP3, MED28, and NCAPG) and a prioritized functional variant involved in the complex regulation of body weight. Additionally, convergent evolution analysis and phenome-wide association studies underscored the conservation of this locus across species. Our study provides a comprehensive understanding of the genetic regulation of body weight through multi-omics analysis in cattle. Our findings contribute to unraveling the genetic mechanisms governing weight-related traits and shed valuable light on the genetic improvement of farm animals.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzaf067","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T14:07:17Z","timestamp":1755526037000},"source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive Multi-omics Analysis of Regulatory Variants for Body Weight in Cattle"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-9074","authenticated-orcid":false,"given":"Qunhao","family":"Niu (\u725b\u7fa4\u7693)","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-3673","authenticated-orcid":false,"given":"Jiayuan","family":"Wu (\u6b66\u5609\u8fdc)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-6821","authenticated-orcid":false,"given":"Tianyi","family":"Wu (\u5434\u5929\u5f0b)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9398-9791","authenticated-orcid":false,"given":"Tianliu","family":"Zhang (\u5f20\u5929\u7559)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]},{"name":"College of Animal Science and Technology, Henan Agricultural University , Zhengzhou 450046,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4448-6391","authenticated-orcid":false,"given":"Tianzhen","family":"Wang (\u738b\u6dfb\u796f)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8058-752X","authenticated-orcid":false,"given":"Xu","family":"Zheng (\u90d1\u65ed)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5168-0141","authenticated-orcid":false,"given":"Zhida","family":"Zhao (\u8d75\u5fd7\u8fbe)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5919-0731","authenticated-orcid":false,"given":"Ling","family":"Xu (\u5f90\u73b2)","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region 999077,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-681X","authenticated-orcid":false,"given":"Zezhao","family":"Wang (\u738b\u6cfd\u662d)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-7288","authenticated-orcid":false,"given":"Bo","family":"Zhu (\u6731\u6ce2)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7701-2331","authenticated-orcid":false,"given":"Lupei","family":"Zhang (\u5f20\u8def\u57f9)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5502-2528","authenticated-orcid":false,"given":"Huijiang","family":"Gao (\u9ad8\u4f1a\u6c5f)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-6705","authenticated-orcid":false,"given":"George E","family":"Liu","sequence":"additional","affiliation":[{"name":"Animal Genomics and Improvement Laboratory, United States Department of Agriculture-Agricultural Research Services , Beltsville, MD 20705,","place":["USA"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-050X","authenticated-orcid":false,"given":"Junya","family":"Li (\u674e\u4fca\u96c5)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8463-6668","authenticated-orcid":false,"given":"Lingyang","family":"Xu (\u5f90\u51cc\u6d0b)","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"2025121319014190100_qzaf067-B1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/gb-2012-13-4-244","article-title":"Genetic 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