{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:25:22Z","timestamp":1773260722149,"version":"3.50.1"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We conducted a comprehensive genetic investigation of obesity in a cohort of 93,673 Korean individuals, categorized by body mass index and waist circumference using Korean-specific and international criteria. To explore the genetic architecture of obesity and its related comorbidities, we performed genome-wide association studies and constructed polygenic risk scores (PRSs) using both conventional single-trait and advanced multiple-trait models, including the PRSsum approach. Our analyses identified genome-wide significant loci and demonstrated their higher heritability for general obesity than for abdominal obesity, and for moderate obesity than for severe obesity. East Asian populations showed stronger genetic correlations between abdominal obesity and obesity-related diseases. Both single-trait and multiple-trait PRSs stratified individuals by risk, with low-PRS individuals exhibiting reduced risk for obesity, hypertension, and type 2 diabetes, while high-PRS individuals displayed elevated risk, particularly under the multiple-trait model. Interaction and mediation analyses revealed distinct genetic pathways through which obesity contributes to disease development. Collectively, our findings revealed key loci and shared genetic mechanisms linking obesity and its comorbidities in the Korean population. These insights highlight the value of multiple-trait PRS models and underscore the importance of ancestry-specific genetic research for addressing the obesity epidemic.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzaf102","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T20:36:14Z","timestamp":1762720574000},"source":"Crossref","is-referenced-by-count":1,"title":["Association of Multiple-trait Polygenic Risk Score with Obesity and Cardiometabolic Diseases in Korean Population"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-1725","authenticated-orcid":false,"given":"Jinyeon","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5150-8181","authenticated-orcid":false,"given":"Nayoung","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7914-1625","authenticated-orcid":false,"given":"Yunmi","family":"Ji","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University , Seoul 08826,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4259-8309","authenticated-orcid":false,"given":"Ahra","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","place":["Republic of Korea"]},{"name":"RexSoft Corp ., Seoul 08826,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3127-7160","authenticated-orcid":false,"given":"Je Hyun","family":"Seo","sequence":"additional","affiliation":[{"name":"Veterans Medical Research Institute, Veterans Health Service Medical Center , Seoul 05368,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-0755","authenticated-orcid":false,"given":"Bumjo","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center , Seoul 07061,","place":["Republic of Korea"]},{"name":"Department of Family Medicine, Seoul National University College of Medicine , Seoul 03080,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-5911","authenticated-orcid":false,"given":"Sungkyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Mathematical Data Science, Hanyang University (ERICA) , Ansan 15588,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-1772","authenticated-orcid":false,"given":"Eun Kyung","family":"Choe","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine , Seoul 03080,","place":["Republic of Korea"]},{"name":"Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center , Seoul 06236,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7447-7045","authenticated-orcid":false,"given":"Woojoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","place":["Republic of Korea"]},{"name":"Institute of Health and Environment, Seoul National University , Seoul 08826,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0339-0131","authenticated-orcid":false,"given":"Jang Won","family":"Son","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , Seoul 06591,","place":["Republic of 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