{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:25:17Z","timestamp":1787120717936,"version":"build-2736575974"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intratumoral heterogeneity (ITH) is a major driver of mortality in breast cancer (BC) patients and a critical factor in the variable therapeutic outcomes observed in BC treatment. Understanding the mechanisms underlying ITH is essential for advancing both clinical and basic BC research. Chromatin accessibility is critical for the regulation of gene expression and cellular identity and plays a central role in shaping ITH and tumor evolution. However, studying chromatin accessibility in situ has been challenging due to the limited availability of technical platforms. Here, we leveraged the spatial assay for transposase-accessible chromatin sequencing (ATAC-seq)\u00a0platform to profile the chromatin accessibility landscape of tumors from six BC patients. Our analyses revealed prominent heterogeneity within tumor regulatory modules and spatial variations in immune cell composition and stromal structures, offering a framework for the investigation of the molecular architecture underlying ITH. Moreover, we identified two tumor subclones with a potential common origin but distinct immune infiltration conferred by regulatory cascades, suggesting that epigenetic regulation may further contribute to the divergent tumor microenvironments and phenotypic diversity of these subclones. Our study provides novel insights into the molecular mechanisms driving ITH and opens up potential avenues for therapeutic intervention.<\/jats:p>","DOI":"10.1093\/gpbjnl\/qzag001","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:04:58Z","timestamp":1768284298000},"source":"Crossref","is-referenced-by-count":2,"title":["Spatial Chromatin Accessibility Analysis of Intratumor Heterogeneity in Breast Cancer"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4116-0432","authenticated-orcid":false,"given":"Yingying","family":"Qian (\u94b1\u83b9\u83b9)","sequence":"first","affiliation":[{"name":"Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230026,","place":["China"]},{"name":"Center for Cell Lineage Technology and Engineering, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative 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Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-1880","authenticated-orcid":false,"given":"Guangyu","family":"Zhang (\u5f20\u5e7f\u96e8)","sequence":"additional","affiliation":[{"name":"Center for Cell Lineage Technology and Engineering, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5987-9609","authenticated-orcid":false,"given":"Cheukfai","family":"Li (\u674e\u712f\u8f89)","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Guangdong Provincial People\u2019s Hospital and Guangdong Academy of Medical Sciences , Guangzhou 510080,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9614-9710","authenticated-orcid":false,"given":"Jiaoyi","family":"lv (\u5415\u5a07\u6021)","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Guangdong Provincial People\u2019s Hospital and Guangdong Academy of Medical Sciences , Guangzhou 510080,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-0373","authenticated-orcid":false,"given":"Qiaorui","family":"Xing (\u90a2\u5de7\u745e)","sequence":"additional","affiliation":[{"name":"Center for Cell Lineage Technology and Engineering, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9805-2930","authenticated-orcid":false,"given":"Guochun","family":"Zhang (\u5f20\u56fd\u6df3)","sequence":"additional","affiliation":[{"name":"Department of 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