{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:10:32Z","timestamp":1770333032948,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,1]]},"DOI":"10.1093\/hmg\/ddh294","type":"journal-article","created":{"date-parts":[[2004,9,15]],"date-time":"2004-09-15T03:25:06Z","timestamp":1095218706000},"page":"2557-2565","source":"Crossref","is-referenced-by-count":47,"title":["Efficiency and consistency of haplotype tagging of dense SNP maps in multiple samples"],"prefix":"10.1093","volume":"13","author":[{"given":"Xiayi","family":"Ke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Durrant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panos","family":"Deloukas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lon R.","family":"Cardon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,9,14]]},"reference":[{"key":"key\n\t\t\t\t20171012083603_DDH294C1","doi-asserted-by":"crossref","unstructured":"Patil, N., Berno, A.J., Hinds, D.A., Barrett, W.A., Doshi, J.M., Hacker, C.R., Kautzer, C.R., Lee, D.H., Marjoribanks, C., McDonough, D.P. et\u00a0al. (2001) Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science, 294, 1719\u20131723.","DOI":"10.1126\/science.1065573"},{"key":"key\n\t\t\t\t20171012083603_DDH294C2","doi-asserted-by":"crossref","unstructured":"Ke, X., Hunt, S., Tapper, W., Lawrence, R., Stavrides, G., Ghori, J., Whittaker, P., Collins, A., Morris, A.P., Bentley, D. et\u00a0al. (2004) The impact of SNP density on fine-scale patterns of linkage disequilibrium. Hum. Mol. Genet., 13, 577\u2013588.","DOI":"10.1093\/hmg\/ddh060"},{"key":"key\n\t\t\t\t20171012083603_DDH294C3","doi-asserted-by":"crossref","unstructured":"Nickerson, D.A., Taylor, S.L., Weiss, K.M., Clark, A.G., Hutchinson, R.G., Stengard, J., Salomaa, V., Vartiainen, E., Boerwinkle, E. and Sing, C.F. (1998) DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene. Nat. Genet., 19, 233\u2013240.","DOI":"10.1038\/907"},{"key":"key\n\t\t\t\t20171012083603_DDH294C4","doi-asserted-by":"crossref","unstructured":"Nickerson, D.A., Taylor, S.L., Fullerton, S.M., Weiss, K.M., Clark, A.G., Stengard, J.H., Salomaa, V., Boerwinkle, E. and Sing, C.F. (2000) Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene. Genome Res., 10, 1532\u20131545.","DOI":"10.1101\/gr.146900"},{"key":"key\n\t\t\t\t20171012083603_DDH294C5","doi-asserted-by":"crossref","unstructured":"Subrahmanyan, L., Eberle, M.A., Clark, A.G., Kruglyak, L. and Nickerson, D.A. (2001) Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. Am. J. Hum. Genet., 69, 381\u2013395.","DOI":"10.1086\/321297"},{"key":"key\n\t\t\t\t20171012083603_DDH294C6","doi-asserted-by":"crossref","unstructured":"Crawford, D.C., Carlson, C.S., Rieder, M.J., Carrington, D.P., Yi, Q., Smith, J.D., Eberle, M.A., Kruglyak, L. and Nickerson, D.A. (2004) Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am. J. Hum. Genet., 74, 610\u2013622.","DOI":"10.1086\/382227"},{"key":"key\n\t\t\t\t20171012083603_DDH294C7","doi-asserted-by":"crossref","unstructured":"Gibbs, R.A., Belmont, J.W., Hardenbol, P., Willis, T.D., Yu, F., Yang, H., Ang, L., Huang, W., Liu, B., Shen, Y. et\u00a0al. (2003) The International HapMap project. Nature, 426, 789\u2013796.","DOI":"10.1038\/nature02168"},{"key":"key\n\t\t\t\t20171012083603_DDH294C8","doi-asserted-by":"crossref","unstructured":"Johnson, G.C., Esposito, L., Barratt, B.J., Smith, A.N., Heward, J., Di Genova, G., Ueda, H., Cordell, H.J., Eaves, I.A., Dudbridge, F. et\u00a0al. (2001) Haplotype tagging for the identification of common disease genes. Nat. Genet., 29, 233\u2013237.","DOI":"10.1038\/ng1001-233"},{"key":"key\n\t\t\t\t20171012083603_DDH294C9","doi-asserted-by":"crossref","unstructured":"Goldstein, D.B., Ahmadi, K.R., Weale, M.E. and Wood, N.W. (2003) Genome scans and candidate gene approaches in the study of common diseases and variable drug responses. Trends Genet., 19, 615\u2013622.","DOI":"10.1016\/j.tig.2003.09.006"},{"key":"key\n\t\t\t\t20171012083603_DDH294C10","doi-asserted-by":"crossref","unstructured":"Zhang, K., Sun, F., Waterman, M.S. and Chen, T. (2003) Haplotype block partition with limited resources and applications to human chromosome 21 haplotype data. Am. J. Hum. Genet., 73, 63\u201373.","DOI":"10.1086\/376437"},{"key":"key\n\t\t\t\t20171012083603_DDH294C11","doi-asserted-by":"crossref","unstructured":"Zhang, K., Deng, M., Chen, T., Waterman, M.S. and Sun, F. (2002) A dynamic programming algorithm for haplotype block partitioning. Proc. Natl Acad. Sci. USA, 99, 7335\u20137339.","DOI":"10.1073\/pnas.102186799"},{"key":"key\n\t\t\t\t20171012083603_DDH294C12","doi-asserted-by":"crossref","unstructured":"Weale, M.E., Depondt, C., Macdonald, S.J., Smith, A., Lai, P.S., Shorvon, S.D., Wood, N.W. and Goldstein, D.B. (2003) Selection and evaluation of tagging SNPs in the neuronal-sodium-channel gene SCN1A: implications for linkage-disequilibrium gene mapping. Am. J. Hum. Genet., 73, 551\u2013565.","DOI":"10.1086\/378098"},{"key":"key\n\t\t\t\t20171012083603_DDH294C13","doi-asserted-by":"crossref","unstructured":"Ke, X. and Cardon, L.R. (2003) Efficient selective screening of haplotype tag SNPs. Bioinformatics, 19, 287\u2013288.","DOI":"10.1093\/bioinformatics\/19.2.287"},{"key":"key\n\t\t\t\t20171012083603_DDH294C14","doi-asserted-by":"crossref","unstructured":"Meng, Z., Zaykin, D.V., Xu, C.F., Wagner, M. and Ehm, M.G. (2003) Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypes. Am. J. Hum. Genet., 73, 115\u2013130.","DOI":"10.1086\/376561"},{"key":"key\n\t\t\t\t20171012083603_DDH294C15","doi-asserted-by":"crossref","unstructured":"Sebastiani, P., Lazarus, R., Weiss, S.T., Kunkel, L.M., Kohane, I.S. and Ramoni, M.F. (2003) Minimal haplotype tagging. Proc. Natl Acad. Sci. USA, 100, 9900\u20139905.","DOI":"10.1073\/pnas.1633613100"},{"key":"key\n\t\t\t\t20171012083603_DDH294C16","doi-asserted-by":"crossref","unstructured":"Cousin, E., Genin, E., Mace, S., Ricard, S., Chansac, C., del Zompo, M. and Deleuze, J.F. (2003) Association studies in candidate genes: strategies to select SNPs to be tested. Hum. Hered., 56, 151\u2013159.","DOI":"10.1159\/000073200"},{"key":"key\n\t\t\t\t20171012083603_DDH294C17","doi-asserted-by":"crossref","unstructured":"Wiuf, C., Laidlaw, Z. and Stumpf, M.P. (2003) Some notes on the combinatorial properties of haplotype tagging. Math. Biosci., 185, 205\u2013216.","DOI":"10.1016\/S0025-5564(03)00089-0"},{"key":"key\n\t\t\t\t20171012083603_DDH294C18","doi-asserted-by":"crossref","unstructured":"Barratt, B.J., Payne, F., Rance, H.E., Nutland, S., Todd, J.A. and Clayton, D.G. (2002) Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design. Ann. Hum. Genet., 66, 393\u2013405.","DOI":"10.1046\/j.1469-1809.2002.00125.x"},{"key":"key\n\t\t\t\t20171012083603_DDH294C19","doi-asserted-by":"crossref","unstructured":"Carlson, C.S., Eberle, M.A., Rieder, M.J., Yi, Q., Kruglyak, L. and Nickerson, D.A. (2004) Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am. J. Hum. Genet., 74, 106\u2013120.","DOI":"10.1086\/381000"},{"key":"key\n\t\t\t\t20171012083603_DDH294C20","doi-asserted-by":"crossref","unstructured":"Chapman, J.M., Cooper, J.D., Todd, J.A. and Clayton, D.G. (2003) Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum. Hered., 56, 18\u201331.","DOI":"10.1159\/000073729"},{"key":"key\n\t\t\t\t20171012083603_DDH294C21","doi-asserted-by":"crossref","unstructured":"Goldstein, D.B., Tate, S.K. and Sisodiya, S.M. (2003) Pharmacogenetics goes genomic. Nat. Rev. Genet., 4, 937\u2013947.","DOI":"10.1038\/nrg1229"},{"key":"key\n\t\t\t\t20171012083603_DDH294C22","doi-asserted-by":"crossref","unstructured":"Lowe, C.E., Cooper, J.D., Chapman, J.M., Barratt, B.J., Twells, R.C., Green, E.A., Savage, D.A., Guja, C., Ionescu-Tirgoviste, C., Tuomilehto-Wolf, E. et\u00a0al. (2004) Cost-effective analysis of candidate genes using htSNPs: a staged approach. Genes Immun.,5, 301\u2013305.","DOI":"10.1038\/sj.gene.6364064"},{"key":"key\n\t\t\t\t20171012083603_DDH294C23","doi-asserted-by":"crossref","unstructured":"Zhang, K., Qin, Z.S., Liu, J.S., Chen, T., Waterman, M.S. and Sun, F. (2004) Haplotype block partitioning and tag SNP selection using genotype data and their applications to association studies. Genome Res., 14, 908\u2013916.","DOI":"10.1101\/gr.1837404"},{"key":"key\n\t\t\t\t20171012083603_DDH294C24","doi-asserted-by":"crossref","unstructured":"Schulze, T.G., Zhang, K., Chen, Y.S., Akula, N., Sun, F. and McMahon, F.J. (2004) Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome. Hum. Mol. Genet., 13, 335\u2013342.","DOI":"10.1093\/hmg\/ddh035"},{"key":"key\n\t\t\t\t20171012083603_DDH294C25","doi-asserted-by":"crossref","unstructured":"Deloukas, P., Matthews, L.H., Ashurst, J., Burton, J., Gilbert, J.G., Jones, M., Stavrides, G., Almeida, J.P., Babbage, A.K., Bagguley, C.L. et\u00a0al. (2001) The DNA sequence and comparative analysis of human chromosome 20. Nature, 414, 865\u2013871.","DOI":"10.1038\/414865a"},{"key":"key\n\t\t\t\t20171012083603_DDH294C26","unstructured":"Cavalli-Sforza, L.L., Menozzi, P. and Piazza, A. (1994) History and Geography of Human Genes. Princeton University Press, Princeton."},{"key":"key\n\t\t\t\t20171012083603_DDH294C27","doi-asserted-by":"crossref","unstructured":"Zondervan, K.T. and Cardon, L.R. (2004) The complex interplay among factors that influence allelic association. Nat. Rev. Genet., 5, 89\u2013100.","DOI":"10.1038\/nrg1270"},{"key":"key\n\t\t\t\t20171012083603_DDH294C28","doi-asserted-by":"crossref","unstructured":"Abecasis, G.R., Cookson, W.O. and Cardon, L.R. (2001) The power to detect linkage disequilibrium with quantitative traits in selected samples. Am. J. Hum. Genet., 68, 1463\u20131474.","DOI":"10.1086\/320590"},{"key":"key\n\t\t\t\t20171012083603_DDH294C29","unstructured":"Muller-Myhsok, B. and Abel, L. (1997) Genetic analysis of complex diseases. Science, 275, 1328\u20131329."},{"key":"key\n\t\t\t\t20171012083603_DDH294C30","doi-asserted-by":"crossref","unstructured":"Tu, I.P. and Whittemore. A.S. (1999) Power of association and linkage tests when the disease alleles are unobserved. Am. J. Hum. Genet., 64, 641\u2013649.","DOI":"10.1086\/302253"},{"key":"key\n\t\t\t\t20171012083603_DDH294C31","doi-asserted-by":"crossref","unstructured":"Zhang, W., Collin, A. and Morton, N. (2004) Does haplotype diversity predict power for association mapping of disease susceptibility? Hum. Genet.,115, 157\u2013164.","DOI":"10.1007\/s00439-004-1122-x"},{"key":"key\n\t\t\t\t20171012083603_DDH294C32","doi-asserted-by":"crossref","unstructured":"Kong, A., Gudbjartsson, D.F., Sainz, J., Jonsdottir, G.M., Gudjonsson, S.A., Richardsson, B., Sigurdardottir, S., Barnard, J., Hallbeck, B., Masson, G. et\u00a0al. (2002) A high-resolution recombination map of the human genome. Nat. Genet., 31, 242\u2013247.","DOI":"10.1038\/ng917"},{"key":"key\n\t\t\t\t20171012083603_DDH294C33","doi-asserted-by":"crossref","unstructured":"Ardlie, K.G., Kruglyak, L. and Seielstad, M. (2002) Patterns of linkage disequilibrium in the human genome. Nat. Rev. Genet., 3, 299\u2013309.","DOI":"10.1038\/nrg777"},{"key":"key\n\t\t\t\t20171012083603_DDH294C34","doi-asserted-by":"crossref","unstructured":"Carlson, C.S., Eberle, M.A., Rieder, M.J., Smith, J.D., Kruglyak, L. and Nickerson, D.A. (2003) Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat. Genet., 33, 518\u2013521.","DOI":"10.1038\/ng1128"},{"key":"key\n\t\t\t\t20171012083603_DDH294C35","doi-asserted-by":"crossref","unstructured":"Gabriel, S.B., Schaffner, S.F., Nguyen, H., Moore, J.M., Roy, J., Blumenstiel. B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M. et\u00a0al. (2002) The structure of haplotype blocks in the human genome. Science, 296, 2225\u20132229.","DOI":"10.1126\/science.1069424"},{"key":"key\n\t\t\t\t20171012083603_DDH294C36","doi-asserted-by":"crossref","unstructured":"Fallin, D. and Schork, N.J. (2000) Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data. Am. J. Hum. Genet., 67, 947\u2013959.","DOI":"10.1086\/303069"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/13\/21\/2557\/17241057\/ddh294.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T04:56:04Z","timestamp":1533012964000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/13\/21\/2557\/587498\/Efficiency-and-consistency-of-haplotype-tagging-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,14]]},"references-count":36,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2004,9,14]]},"published-print":{"date-parts":[[2004,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddh294","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,11,1]]},"published":{"date-parts":[[2004,9,14]]}}}