{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T15:23:27Z","timestamp":1769527407460,"version":"3.49.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,15]]},"DOI":"10.1093\/hmg\/ddp569","type":"journal-article","created":{"date-parts":[[2009,12,25]],"date-time":"2009-12-25T02:07:16Z","timestamp":1261706836000},"page":"1058-1065","source":"Crossref","is-referenced-by-count":106,"title":["Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis"],"prefix":"10.1093","volume":"19","author":[{"given":"Luciano H.","family":"Apponi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara W.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro R.","family":"Valentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita H.","family":"Corbett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace K.","family":"Pavlath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,12,24]]},"reference":[{"key":"key\n\t\t\t\t20170522122451_DDP569C1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbaexp.2004.03.008","article-title":"Structure and function of poly(A) binding proteins","volume":"1678","author":"Kuhn","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170522122451_DDP569C2","doi-asserted-by":"crossref","first-page":"16916","DOI":"10.1074\/jbc.M209886200","article-title":"The RNA binding domains of the nuclear poly(A)-binding protein","volume":"278","author":"Kuhn","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522122451_DDP569C3","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1093\/hmg\/10.21.2341","article-title":"Oligomerization of polyalanine expanded PABPN1 facilitates nuclear protein aggregation that is associated with cell death","volume":"10","author":"Fan","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522122451_DDP569C4","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/oxfordjournals.hmg.a018924","article-title":"Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA","volume":"9","author":"Calado","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522122451_DDP569C5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1017\/S1355838200991908","article-title":"Deciphering the cellular pathway for transport of poly(A)-binding protein II","volume":"6","author":"Calado","year":"2000","journal-title":"RNA"},{"key":"key\n\t\t\t\t20170522122451_DDP569C6","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1242\/jcs.113.12.2309","article-title":"Localization of poly(A)-binding protein 2 (PABP2) in nuclear speckles is independent of import into the nucleus and requires binding to poly(A) RNA","volume":"113","author":"Calado","year":"2000","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170522122451_DDP569C7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/ng0298-164","article-title":"Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy","volume":"18","author":"Brais","year":"1998","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522122451_DDP569C8","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1056\/NEJM196212202672501","article-title":"Oculopharyngeal muscular dystrophy. A familial disease of late life characterized by dysphagia and progressive ptosis of the evelids","volume":"267","author":"Victor","year":"1962","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170522122451_DDP569C9","first-page":"574","article-title":"Oculopharyngeal muscular dystrophy - an under-diagnosed disorder?","volume":"135","author":"Ruegg","year":"2005","journal-title":"Swiss Med. Wkly"},{"key":"key\n\t\t\t\t20170522122451_DDP569C10","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00415-003-0201-6","article-title":"Oculopharyngeal muscular dystrophy with limb girdle weakness as major complaint","volume":"250","author":"Van Der Sluijs","year":"2003","journal-title":"J. Neurol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00692226","article-title":"Nuclear inclusions in oculopharyngeal dystrophy","volume":"49","author":"Tome","year":"1980","journal-title":"Acta Neuropathol."},{"issue":"Suppl. 1","key":"key\n\t\t\t\t20170522122451_DDP569C12","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/S0960-8966(97)00085-0","article-title":"Morphological changes in muscle fibers in oculopharyngeal muscular dystrophy","volume":"7","author":"Tome","year":"1997","journal-title":"Neuromuscul. Disord."},{"key":"key\n\t\t\t\t20170522122451_DDP569C13","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.devcel.2005.09.002","article-title":"An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila","volume":"9","author":"Benoit","year":"2005","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20170522122451_DDP569C14","doi-asserted-by":"crossref","first-page":"7552","DOI":"10.1074\/jbc.M610512200","article-title":"Regulation of the nuclear poly(A)-binding protein by arginine methylation in fission yeast","volume":"282","author":"Perreault","year":"2007","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522122451_DDP569C15","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1093\/emboj\/18.8.2273","article-title":"Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3\u2032-end processing machinery","volume":"18","author":"Chen","year":"1999","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170522122451_DDP569C16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/physrev.00019.2003","article-title":"Cellular and molecular regulation of muscle regeneration","volume":"84","author":"Charge","year":"2004","journal-title":"Physiol. Rev."},{"key":"key\n\t\t\t\t20170522122451_DDP569C17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000075028","article-title":"Forming a multinucleated cell: molecules that regulate myoblast fusion","volume":"176","author":"Horsley","year":"2004","journal-title":"Cells Tissues Organs"},{"key":"key\n\t\t\t\t20170522122451_DDP569C18","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.bbagen.2007.03.003","article-title":"Modulations of the calcineurin\/NF-AT pathway in skeletal muscle atrophy","volume":"1770","author":"Costelli","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170522122451_DDP569C19","doi-asserted-by":"crossref","first-page":"22803","DOI":"10.1074\/jbc.M109.018226","article-title":"Poly(A) tail length is controlled by the nuclear poly(A)-binding protein regulating the interaction between poly(A) polymerase and the cleavage and polyadenylation specificity factor","volume":"284","author":"Kuhn","year":"2009","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522122451_DDP569C20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.semcdb.2005.07.006","article-title":"MyoD and the transcriptional control of myogenesis","volume":"16","author":"Berkes","year":"2005","journal-title":"Semin. Cell Dev. Biol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ceb.2004.03.013","article-title":"mRNA export: an assembly line from genes to nuclear pores","volume":"16","author":"Vinciguerra","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C22","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1128\/MCB.16.4.1534","article-title":"Role of polyadenylation in nucleocytoplasmic transport of mRNA","volume":"16","author":"Huang","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0014-4827(03)00123-X","article-title":"Nuclear poly(A)-binding protein PABPN1 is associated with RNA polymerase II during transcription and accompanies the released transcript to the nuclear pore","volume":"286","author":"Bear","year":"2003","journal-title":"Exp. Cell Res."},{"key":"key\n\t\t\t\t20170522122451_DDP569C24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1242\/jcs.1995.Supplement_19.2","article-title":"The influence of 5\u2032 and 3\u2032 end structures on pre-mRNA metabolism","volume":"19","author":"Lewis","year":"1995","journal-title":"J. Cell Sci. Suppl."},{"key":"key\n\t\t\t\t20170522122451_DDP569C25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0959-437X(97)80132-3","article-title":"Life and death in the cytoplasm: messages from the 3\u2032 end","volume":"7","author":"Wickens","year":"1997","journal-title":"Curr. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t20170522122451_DDP569C26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1017\/S1355838201010147","article-title":"Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3\u2032-end formation of nascent transcripts","volume":"7","author":"Hilleren","year":"2001","journal-title":"RNA"},{"key":"key\n\t\t\t\t20170522122451_DDP569C27","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S1097-2765(01)00232-5","article-title":"A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription","volume":"7","author":"Jensen","year":"2001","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170522122451_DDP569C28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4161\/rna.6.3.8330","article-title":"Mechanisms of nuclear mRNA quality control","volume":"6","author":"Fasken","year":"2009","journal-title":"RNA Biol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1101\/gad.1616008","article-title":"Definition of global and transcript-specific mRNA export pathways in metazoans","volume":"22","author":"Farny","year":"2008","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170522122451_DDP569C30","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1006\/jmbi.2000.3572","article-title":"The nuclear poly(A) binding protein, PABP2, forms an oligomeric particle covering the length of the poly(A) tail","volume":"297","author":"Keller","year":"2000","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbadis.2006.10.003","article-title":"Oculopharyngeal muscular dystrophy: recent advances in the understanding of the molecular pathogenic mechanisms and treatment strategies","volume":"1772","author":"Abu-Baker","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170522122451_DDP569C32","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1093\/hmg\/ddg293","article-title":"Involvement of the ubiquitin\u2013proteasome pathway and molecular chaperones in oculopharyngeal muscular dystrophy","volume":"12","author":"Abu-Baker","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522122451_DDP569C33","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nm1242","article-title":"Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice","volume":"11","author":"Davies","year":"2005","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170522122451_DDP569C34","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.biocel.2006.01.016","article-title":"Oculopharyngeal muscular dystrophy: potential therapies for an aggregate-associated disorder","volume":"38","author":"Davies","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C35","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1038\/sj.emboj.7601117","article-title":"A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1","volume":"25","author":"Chartier","year":"2006","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170522122451_DDP569C36","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.yexcr.2008.02.005","article-title":"PABPN1 polyalanine tract deletion and long expansions modify its aggregation pattern and expression","volume":"314","author":"Klein","year":"2008","journal-title":"Exp. Cell Res."},{"key":"key\n\t\t\t\t20170522122451_DDP569C37","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/hmg\/ddh101","article-title":"Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus","volume":"13","author":"Berciano","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522122451_DDP569C38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-2008-1040826","article-title":"Oculopharyngeal muscular dystrophy","volume":"19","author":"Brais","year":"1999","journal-title":"Semin. Neurol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C39","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/hmg\/ddm382","article-title":"Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation","volume":"17","author":"Davies","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522122451_DDP569C40","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.nmd.2006.07.022","article-title":"Premature proliferative arrest of cricopharyngeal myoblasts in oculo-pharyngeal muscular dystrophy: Therapeutic perspectives of autologous myoblast transplantation","volume":"16","author":"Perie","year":"2006","journal-title":"Neuromuscul. Disord."},{"key":"key\n\t\t\t\t20170522122451_DDP569C41","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1083\/jcb.125.6.1275","article-title":"Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy","volume":"125","author":"Rando","year":"1994","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C42","doi-asserted-by":"crossref","first-page":"C1753","DOI":"10.1152\/ajpcell.00292.2004","article-title":"Skeletal muscle atrophy leads to loss and dysfunction of muscle precursor cells","volume":"287","author":"Mitchell","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C43","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0960-9822(01)00371-2","article-title":"Analysis of an essential requirement for the poly(A) binding protein function using cross-species complementation","volume":"11","author":"Chekanova","year":"2001","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170522122451_DDP569C44","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/JVI.01205-07","article-title":"The 3\u2032 untranslated region of sindbis virus represses deadenylation of viral transcripts in mosquito and Mammalian cells","volume":"82","author":"Garneau","year":"2008","journal-title":"J. Virol."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/article\/19\/6\/1058\/2527084\/Loss-of-nuclear-polyAbinding-protein-1-causes","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T14:13:03Z","timestamp":1634652783000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddp569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,24]]},"references-count":44,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,12,24]]},"published-print":{"date-parts":[[2010,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddp569","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12,24]]}}}