{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:15:51Z","timestamp":1777670151746,"version":"3.51.4"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health\/National Cancer Institute Cancer Center Support","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Broad adoption of digital pathology (DP) is still lacking, and examples for DP connecting diagnostic, research, and educational use cases are missing. We blueprint a holistic DP solution at a large academic medical center ubiquitously integrated into clinical workflows; researchapplications including molecular, genetic, and tissue databases; and educational processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We built a vendor-agnostic, integrated viewer for reviewing, annotating, sharing, and quality assurance of digital slides in a clinical or research context. It is the first homegrown viewer cleared by New York State provisional approval in 2020 for primary diagnosis and remote sign-out during the COVID-19 (coronavirus disease 2019) pandemic. We further introduce an interconnected Honest Broker for BioInformatics Technology (HoBBIT) to systematically compile and share large-scale DP research datasets including anonymized images, redacted pathology reports, and clinical data of patients with consent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The solution has been operationally used over 3 years by 926 pathologists and researchers evaluating 288 903 digital slides. A total of 51% of these were reviewed within 1 month after scanning. Seamless integration of the viewer into 4 hospital systems clearly increases the adoption of DP. HoBBIT directly impacts the translation of knowledge in pathology into effective new health measures, including artificial intelligence\u2013driven detection models for prostate cancer, basal cell carcinoma, and breast cancer metastases, developed and validated on thousands of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We highlight major challenges and lessons learned when going digital to provide orientation for other pathologists. Building interconnected solutions will not only increase adoption of DP, but also facilitate next-generation computational pathology at scale for enhanced cancer research.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jamia\/ocab085","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T20:56:08Z","timestamp":1620161768000},"page":"1874-1884","source":"Crossref","is-referenced-by-count":72,"title":["Integrated digital pathology at scale: A solution for clinical diagnostics and cancer research at a large academic medical center"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1353-8921","authenticated-orcid":false,"given":"Peter J","family":"Sch\u00fcffler","sequence":"first","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"},{"name":"Institute of Pathology, Technical University of Munich, Munich, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-9102","authenticated-orcid":false,"given":"Luke","family":"Geneslaw","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-9485","authenticated-orcid":false,"given":"D Vijay K","family":"Yarlagadda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7536-1746","authenticated-orcid":false,"given":"Matthew G","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"given":"Jennifer","family":"Samboy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, 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York, USA"}]},{"given":"Juan C","family":"Perin","sequence":"additional","affiliation":[{"name":"Department of Information Systems, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4491-0033","authenticated-orcid":false,"given":"Young Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Medicine, Stanford University, Stanford, California, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-1239","authenticated-orcid":false,"given":"Umeshkumar K","family":"Bhanot","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"given":"Michael H A","family":"Roehrl","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"},{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8147-933X","authenticated-orcid":false,"given":"Orly","family":"Ardon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-0936","authenticated-orcid":false,"given":"Sarah","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"given":"Dilip D","family":"Giri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-3968","authenticated-orcid":false,"given":"Carlie S","family":"Sigel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"given":"Lee K","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2935-6014","authenticated-orcid":false,"given":"Melissa","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"given":"Christina","family":"Virgo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"given":"Christine","family":"England","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}]},{"given":"Yukako","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, 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