{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:08:51Z","timestamp":1740136131721,"version":"3.37.3"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001873"],"award-info":[{"award-number":["UL1TR001873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000092","name":"National Library of Medicine","doi-asserted-by":"publisher","award":["R01LM009886"],"award-info":[{"award-number":["R01LM009886"]}],"id":[{"id":"10.13039\/100000092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hundreds of interventional clinical trials have been launched in the United States to identify effective treatment strategies for combating the coronavirus disease 2019 (COVID-19) pandemic. However, to date, only a small fraction of these trials have completed enrollment, delaying the scientific investigation of COVID-19 and its treatment options. This study presents novel metrics to examine the geographic alignment between COVID-19 hotspots and interventional clinical trial sites and evaluate trial access over time during the evolving pandemic. Using temporal COVID-19 case data from USAFacts.org and trial data from ClinicalTrials.gov, U.S. counties were categorized based on their numbers of cases and trials. Our analysis suggests that alignment and access have worsened as the pandemic shifted over time. We recommend strategies and metrics to evaluate the alignment between cases and trials. Future studies are warranted to investigate the impact of the misalignment of cases and clinical trial sites on clinical trial recruitment.<\/jats:p>","DOI":"10.1093\/jamia\/ocab167","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T11:18:43Z","timestamp":1627989523000},"page":"2461-2466","source":"Crossref","is-referenced-by-count":4,"title":["Misalignment between COVID-19 hotspots and clinical trial sites"],"prefix":"10.1093","volume":"28","author":[{"given":"Lauren","family":"Franks","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Columbia University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell S V","family":"Elkind","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA"},{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA, and"},{"name":"Irving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muredach P","family":"Reilly","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA"},{"name":"Irving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhua","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Columbia University, New York, New York, USA"},{"name":"Irving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shing M","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA"},{"name":"Irving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"issue":"10","key":"2021101218233611700_ocab167-B1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMoa2001191","article-title":"First case of 2019 novel coronavirus in the United States","volume":"382 (","author":"Holshue","year":"2020","journal-title":"N Engl J Med"},{"key":"2021101218233611700_ocab167-B2"},{"key":"2021101218233611700_ocab167-B3"},{"issue":"12","key":"2021101218233611700_ocab167-B4","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S2213-2600(20)30460-4","article-title":"Completion of clinical trials in light of COVID-19","volume":"8","author":"Burki","year":"2020","journal-title":"Lancet Respir Med"},{"key":"2021101218233611700_ocab167-B5"},{"key":"2021101218233611700_ocab167-B6"},{"key":"2021101218233611700_ocab167-B7"},{"key":"2021101218233611700_ocab167-B8","first-page":"1489","article-title":"A real-time screening alert improves patient recruitment efficiency","volume":"2011","author":"Weng","year":"2011","journal-title":"AMIA Annu Symp Proc"},{"issue":"15","key":"2021101218233611700_ocab167-B9","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1056\/NEJMp2019989","article-title":"Improve clinical trial enrollment \u2013 in the COVID-19 era and beyond","volume":"383 (","author":"North","year":"2020","journal-title":"N Engl J Med"},{"key":"2021101218233611700_ocab167-B10","first-page":"205","article-title":"Treatment COVID-19 in rural America","volume":"35","author":"Dandachi","year":"2020","journal-title":"J Rural Health"},{"year":"2020","key":"2021101218233611700_ocab167-B11"}],"container-title":["Journal of the American Medical Informatics Association"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jamia\/advance-article-pdf\/doi\/10.1093\/jamia\/ocab167\/39773333\/ocab167.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jamia\/article-pdf\/28\/11\/2461\/40576468\/ocab167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jamia\/article-pdf\/28\/11\/2461\/40576468\/ocab167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T22:44:41Z","timestamp":1634510681000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jamia\/article\/28\/11\/2461\/6342419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":11,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,8,18]]},"published-print":{"date-parts":[[2021,10,12]]}},"URL":"https:\/\/doi.org\/10.1093\/jamia\/ocab167","relation":{},"ISSN":["1527-974X"],"issn-type":[{"type":"electronic","value":"1527-974X"}],"subject":[],"published-other":{"date-parts":[[2021,11,1]]},"published":{"date-parts":[[2021,8,18]]}}}