{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:08:19Z","timestamp":1740136099567,"version":"3.37.3"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NCI Cancer Center Support","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Electronic health record (EHR) data are a valuable resource for population health research but lack critical information such as relationships between individuals. Emergency contacts in EHRs can be used to link family members, creating a population that is more representative of a community than traditional family cohorts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>We revised a published algorithm: relationship inference from the electronic health record (RIFTEHR). Our version, Pythonic RIFTEHR (P-RIFTEHR), identifies a patient\u2019s emergency contacts, matches them to existing patients (when available) using network graphs, checks for conflicts, and infers new relationships. P-RIFTEHR was run on December 15, 2021 in the Northwestern Medicine Electronic Data Warehouse (NMEDW) on approximately 2.95 million individuals and was validated using the existing link between children born at NM hospitals and their mothers. As proof-of-concept, we modeled the association between parent and child obesity using logistic regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The P-RIFTEHR algorithm matched 1\u200a157\u200a454 individuals in 448\u200a278 families. The median family size was 2, the largest was 32 persons, and 247 families spanned 4 generations or more. Validation of the mother\u2013child pairs resulted in 95.1% sensitivity. Children were 2 times more likely to be obese if a parent is obese (OR: 2.30; 95% CI, 2.23\u20132.37).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>P-RIFTEHR can identify familiar relationships in a large, diverse population in an integrated health system. Estimates of parent\u2013child inheritability of obesity using family structures identified by the algorithm were consistent with previously published estimates from traditional cohort studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jamia\/ocad028","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T16:37:48Z","timestamp":1677688668000},"page":"915-922","source":"Crossref","is-referenced-by-count":2,"title":["Using electronic health record data to link families: an illustrative example using intergenerational patterns of obesity"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6692-0104","authenticated-orcid":false,"given":"Amy E","family":"Krefman","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine , Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Ghamsari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tulane University School of Medicine , New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R","family":"Turner","sequence":"additional","affiliation":[{"name":"IT Research Computing Services, Northwestern University , Evanston, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Lu","sequence":"additional","affiliation":[{"name":"Northwestern Medicine Enterprise Data Warehouse, Northwestern University Feinberg School of Medicine , Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Borsje","sequence":"additional","affiliation":[{"name":"Northwestern Medicine Enterprise Data Warehouse, Northwestern University Feinberg School of Medicine , Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colby Witherup","family":"Wood","sequence":"additional","affiliation":[{"name":"IT Research Computing Services, Northwestern University , Evanston, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia C","family":"Petito","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine , Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda C G","family":"Polubriaginof","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center , New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Schneider","sequence":"additional","affiliation":[{"name":"Northwestern Medicine Enterprise Data Warehouse, Northwestern University Feinberg School of Medicine , Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-2541","authenticated-orcid":false,"given":"Faraz","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine , Chicago, Illinois, USA"},{"name":"Division of Cardiology, Northwestern University Feinberg School of Medicine , Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norrina B","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine , Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"2023041909005145800_ocad028-B1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev-publhealth-032315-021353","article-title":"Using electronic health records for population health research: a review of methods and applications","volume":"37","author":"Casey","year":"2016","journal-title":"Annu Rev Public Health"},{"key":"2023041909005145800_ocad028-B2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-publhealth-031914-122747","article-title":"Uses of electronic health records for public health surveillance to advance public health","volume":"36","author":"Birkhead","year":"2015","journal-title":"Annu Rev Public Health"},{"issue":"9","key":"2023041909005145800_ocad028-B3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11883-021-00949-w","article-title":"Social determinants of health and cardiovascular disease: current state and future directions towards healthcare equity","volume":"23","author":"Jilani","year":"2021","journal-title":"Curr Atheroscler Rep"},{"issue":"9","key":"2023041909005145800_ocad028-B4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/CIR.0000000000000228","article-title":"Social determinants of risk and outcomes for cardiovascular disease: a scientific statement from the American Heart Association","volume":"132","author":"Havranek","year":"2015","journal-title":"Circulation"},{"issue":"2","key":"2023041909005145800_ocad028-B5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/BF03391652","article-title":"Social determinants of cardiovascular diseases","volume":"33","author":"Lang","year":"2011","journal-title":"Public Health Rev"},{"key":"2023041909005145800_ocad028-B6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev-publhealth-032315-021859","article-title":"Preventing obesity across generations: evidence for early life Intervention","volume":"37","author":"Haire-Joshu","year":"2016","journal-title":"Annu Rev Public Health"},{"issue":"3","key":"2023041909005145800_ocad028-B7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/17477160903268308","article-title":"Body weight and height data in electronic medical records of children","volume":"5","author":"Smith","year":"2010","journal-title":"Int J Pediatr Obes"},{"issue":"7","key":"2023041909005145800_ocad028-B8","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.cell.2018.04.032","article-title":"Disease heritability inferred from familial relationships reported in medical records","volume":"173","author":"Polubriaginof","year":"2018","journal-title":"Cell"},{"year":"2022","author":"Ghamsari","key":"2023041909005145800_ocad028-B9"},{"issue":"3","key":"2023041909005145800_ocad028-B10","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3945\/an.116.013235","article-title":"A systematic examination of the association between parental and child obesity across countries","volume":"8","author":"Wang","year":"2017","journal-title":"Adv Nutr"},{"key":"2023041909005145800_ocad028-B11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.socscimed.2013.05.035","article-title":"Intergenerational and socioeconomic gradients of child obesity","volume":"93","author":"Costa-Font","year":"2013","journal-title":"Soc Sci Med"},{"key":"2023041909005145800_ocad028-B12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ehb.2015.06.002","article-title":"The intergenerational transmission of BMI in China","volume":"19","author":"Dolton","year":"2015","journal-title":"Econ Hum Biol"},{"key":"2023041909005145800_ocad028-B13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ehb.2016.11.005","article-title":"The intergenerational transmission of body mass index across countries","volume":"24","author":"Dolton","year":"2017","journal-title":"Econ Hum Biol"},{"issue":"11","key":"2023041909005145800_ocad028-B14","doi-asserted-by":"crossref","first-page":"e0166585","DOI":"10.1371\/journal.pone.0166585","article-title":"Intergenerational transmission of overweight and obesity from parents to their adolescent offspring\u2014the HUNT study","volume":"11","author":"N\u00e6ss","year":"2016","journal-title":"PLoS One"},{"key":"2023041909005145800_ocad028-B15","doi-asserted-by":"crossref","first-page":"100723","DOI":"10.1016\/j.ssmph.2020.100723","article-title":"Intergenerational social mobility and body mass index trajectories\u2014a follow-up study from Finland","volume":"13","author":"Salmela","year":"2021","journal-title":"SSM Popul Health"},{"key":"2023041909005145800_ocad028-B16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ypmed.2016.07.004","article-title":"High perceived social support protects against the intergenerational transmission of obesity: the Cardiovascular Risk in Young Finns Study","volume":"90","author":"Serlachius","year":"2016","journal-title":"Prev Med"},{"volume-title":"SciPy2008","year":"2008","author":"Varoquaux","key":"2023041909005145800_ocad028-B17"},{"issue":"5","key":"2023041909005145800_ocad028-B18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis"},{"year":"2016","key":"2023041909005145800_ocad028-B19"},{"issue":"134","key":"2023041909005145800_ocad028-B20","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2017.0213","article-title":"The coefficient of determination R(2) and intra-class correlation coefficient from generalized linear mixed-effects models revisited and expanded","volume":"14","author":"Nakagawa","year":"2017","journal-title":"J R Soc Interface"},{"issue":"3","key":"2023041909005145800_ocad028-B21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cgh.2018.06.016","article-title":"Low rates of screening for celiac disease among family members","volume":"17","author":"Faye","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"13","key":"2023041909005145800_ocad028-B22","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJM199709253371301","article-title":"Predicting obesity in young adulthood from childhood and parental obesity","volume":"337","author":"Whitaker","year":"1997","journal-title":"N Engl J Med"},{"issue":"1","key":"2023041909005145800_ocad028-B23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ehb.2009.11.002","article-title":"Measures of the intergenerational transmission of body mass index between mothers and their children in the United States, 1981\u20132004","volume":"8","author":"Classen","year":"2010","journal-title":"Econ Hum Biol"}],"container-title":["Journal of the American Medical Informatics Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jamia\/article-pdf\/30\/5\/915\/49873040\/ocad028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jamia\/article-pdf\/30\/5\/915\/49873040\/ocad028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T09:22:55Z","timestamp":1681896175000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jamia\/article\/30\/5\/915\/7060050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,28]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,2,28]]},"published-print":{"date-parts":[[2023,4,19]]}},"URL":"https:\/\/doi.org\/10.1093\/jamia\/ocad028","relation":{},"ISSN":["1067-5027","1527-974X"],"issn-type":[{"type":"print","value":"1067-5027"},{"type":"electronic","value":"1527-974X"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2023,2,28]]}}}