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Understanding the interplay of SDoH and health outcomes is critical to reducing healthcare inequalities and transforming a \u201csick care\u201d system into a \u201chealth-promoting\u201d system. To address the SDOH terminology gap and better embed relevant elements in advanced biomedical informatics, we propose an SDoH ontology (SDoHO), which represents fundamental SDoH factors and their relationships in a standardized and measurable way.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n Drawing on the content of existing ontologies relevant to certain aspects of SDoH, we used a top-down approach to formally model classes, relationships, and constraints based on multiple SDoH-related resources. Expert review and coverage evaluation, using a bottom-up approach employing clinical notes data and a national survey, were performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We constructed the SDoHO with 708 classes, 106 object properties, and 20 data properties, with 1,561 logical axioms and 976 declaration axioms in the current version. Three experts achieved 0.967 agreement in the semantic evaluation of the ontology. A comparison between the coverage of the ontology and SDOH concepts in 2 sets of clinical notes and a national survey instrument also showed satisfactory results.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n SDoHO could potentially play an essential role in providing a foundation for a comprehensive understanding of the associations between SDoH and health outcomes and paving the way for health equity across populations.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n SDoHO has well-designed hierarchies, practical objective properties, and versatile functionalities, and the comprehensive semantic and coverage evaluation achieved promising performance compared to the existing ontologies relevant to SDoH.<\/jats:p>\n 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