{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:39:47Z","timestamp":1772138387985,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Vanderbilt University Department of Biostatistics Development","award":["R21DK127075"],"award-info":[{"award-number":["R21DK127075"]}]},{"name":"Vanderbilt University Department of Biostatistics Development","award":["P50GM115305"],"award-info":[{"award-number":["P50GM115305"]}]},{"name":"Vanderbilt University Department of Biostatistics Development","award":["R01 MH118233"],"award-info":[{"award-number":["R01 MH118233"]}]},{"name":"The Vanderbilt University Medical Center datase"},{"name":"Vanderbilt University Medical Center\u2019s SD\/BioVU"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shared Instrumentation","award":["S10RR025141"],"award-info":[{"award-number":["S10RR025141"]}]},{"name":"Shared Instrumentation","award":["UL1TR002243"],"award-info":[{"award-number":["UL1TR002243"]}]},{"name":"Shared Instrumentation","award":["UL1TR000445"],"award-info":[{"award-number":["UL1TR000445"]}]},{"name":"Shared Instrumentation","award":["UL1RR024975"],"award-info":[{"award-number":["UL1RR024975"]}]},{"name":"Shared Instrumentation","award":["U01HG004798"],"award-info":[{"award-number":["U01HG004798"]}]},{"name":"Shared Instrumentation","award":["R01NS032830"],"award-info":[{"award-number":["R01NS032830"]}]},{"name":"Shared Instrumentation","award":["RC2GM092618"],"award-info":[{"award-number":["RC2GM092618"]}]},{"name":"Shared Instrumentation","award":["P50GM115305"],"award-info":[{"award-number":["P50GM115305"]}]},{"name":"Shared Instrumentation","award":["U01HG006378"],"award-info":[{"award-number":["U01HG006378"]}]},{"name":"Shared Instrumentation","award":["U19HL065962"],"award-info":[{"award-number":["U19HL065962"]}]},{"name":"Shared Instrumentation","award":["R01HD074711"],"award-info":[{"award-number":["R01HD074711"]}]},{"name":"UK Biobank Resource","award":["43397"],"award-info":[{"award-number":["43397"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To address the need for interactive visualization tools and databases in characterizing multimorbidity patterns across different populations, we developed the Phenome-wide Multi-Institutional Multimorbidity Explorer (PheMIME). This tool leverages three large-scale EHR systems to facilitate efficient analysis and visualization of disease multimorbidity, aiming to reveal both robust and novel disease associations that are consistent across different systems and to provide insight for enhancing personalized healthcare strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>PheMIME integrates summary statistics from phenome-wide analyses of disease multimorbidities, utilizing data from Vanderbilt University Medical Center, Mass General Brigham, and the UK Biobank. It offers interactive and multifaceted visualizations for exploring multimorbidity. Incorporating an enhanced version of associationSubgraphs, PheMIME also enables dynamic analysis and inference of disease clusters, promoting the discovery of complex multimorbidity patterns. A case study on schizophrenia demonstrates its capability for generating interactive visualizations of multimorbidity networks within and across multiple systems. Additionally, PheMIME supports diverse multimorbidity-based discoveries, detailed further in online case studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PheMIME is accessible at https:\/\/prod.tbilab.org\/PheMIME\/. A comprehensive tutorial and multiple case studies for demonstration are available at https:\/\/prod.tbilab.org\/PheMIME_supplementary_materials\/. The source code can be downloaded from https:\/\/github.com\/tbilab\/PheMIME.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>PheMIME represents a significant advancement in medical informatics, offering an efficient solution for accessing, analyzing, and interpreting the complex and noisy real-world patient data in electronic health records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PheMIME provides an extensive multimorbidity knowledge base that consolidates data from three EHR systems, and it is a novel interactive tool designed to analyze and visualize multimorbidities across multiple EHR datasets. It stands out as the first of its kind to offer extensive multimorbidity knowledge integration with substantial support for efficient online analysis and interactive visualization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jamia\/ocae182","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T02:27:27Z","timestamp":1721269647000},"page":"2440-2446","source":"Crossref","is-referenced-by-count":3,"title":["PheMIME: an interactive web app and knowledge base for phenome-wide, multi-institutional multimorbidity analysis"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0873-5217","authenticated-orcid":false,"given":"Siwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Strayer","sequence":"additional","affiliation":[{"name":"Posit PBC , Boston, MA 02210,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tess","family":"Vessels","sequence":"additional","affiliation":[{"name":"Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karmel","family":"Choi","sequence":"additional","affiliation":[{"name":"Psychiatric & Neuro Developmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital , Boston, MA 02114,","place":["United States"]},{"name":"Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital , Boston, MA 02114,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey W","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Statistics, North Carolina State University , Raleigh, NC 27695,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosmin A","family":"Bejan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan S","family":"Hsi","sequence":"additional","affiliation":[{"name":"Department of Urology, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander G","family":"Bick","sequence":"additional","affiliation":[{"name":"Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Digna R","family":"Velez Edwards","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R","family":"Savona","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J","family":"Phillips","sequence":"additional","affiliation":[{"name":"Center for Drug Safety and Immunology, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]},{"name":"Institute for Immunology and Infectious Diseases, Murdoch University , Murdoch, WA 6150,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill M","family":"Pulley","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Science, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesley H","family":"Self","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Science, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilkins Consuelo","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Science, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan M","family":"Roden","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan W","family":"Smoller","sequence":"additional","affiliation":[{"name":"Psychiatric & Neuro Developmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital , Boston, MA 02114,","place":["United States"]},{"name":"Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital , Boston, MA 02114,","place":["United States"]},{"name":"Stanley Center for Psychiatric Research, Broad Institute , Cambridge, MA 02142,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas M","family":"Ruderfer","sequence":"additional","affiliation":[{"name":"Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]},{"name":"Department of Biomedical Informatics, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]},{"name":"Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center , Nashville, TN 37212,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3752-4006","authenticated-orcid":false,"given":"Yaomin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]},{"name":"Department of Biomedical Informatics, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"issue":"12","key":"2024102107512809600_ocae182-B1","doi-asserted-by":"publisher","first-page":"e599","DOI":"10.1016\/S2468-2667(19)30222-1","article-title":"Multimorbidity\u2014a defining challenge for health systems","volume":"4","author":"Pearson-Stuttard","year":"2019","journal-title":"Lancet Public Health"},{"issue":"706","key":"2024102107512809600_ocae182-B2","doi-asserted-by":"publisher","first-page":"e381","DOI":"10.3399\/BJGP.2020.0883","article-title":"Treatment burden for patients with multimorbidity: cross-sectional study with exploration of a single-item measure","volume":"71","author":"Morris","year":"2021","journal-title":"Br J Gen Pract"},{"issue":"724","key":"2024102107512809600_ocae182-B3","doi-asserted-by":"publisher","first-page":"e816","DOI":"10.3399\/BJGP.2022.0103","article-title":"Change in treatment burden among people with multimorbidity: a follow-up survey","volume":"72","author":"Hounkpatin","year":"2022","journal-title":"Br J Gen Pract"},{"issue":"1","key":"2024102107512809600_ocae182-B4","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/s41572-022-00376-4","article-title":"Multimorbidity","volume":"8","author":"Skou","year":"2022","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"2024102107512809600_ocae182-B5","doi-asserted-by":"publisher","first-page":"11643","DOI":"10.1038\/s41598-022-15723-4","article-title":"Multimorbidity patterns and hospitalisation occurrence in adults and older adults aged 50 years or over","volume":"12","author":"Rodrigues","year":"2022","journal-title":"Sci Rep"},{"issue":"9","key":"2024102107512809600_ocae182-B6","doi-asserted-by":"publisher","first-page":"e0183966","DOI":"10.1371\/journal.pone.0183966","article-title":"Pattern and severity of multimorbidity among patients attending primary care settings in Odisha, India","volume":"12","author":"Pati","year":"2017","journal-title":"PLoS One"},{"issue":"8","key":"2024102107512809600_ocae182-B7","doi-asserted-by":"publisher","first-page":"e0238091","DOI":"10.1371\/journal.pone.0238091","article-title":"Multimorbidity, polypharmacy, and COVID-19 infection within the UK Biobank cohort","volume":"15","author":"McQueenie","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"2024102107512809600_ocae182-B8","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s12967-018-1542-3","article-title":"Association of viral hepatitis and bipolar disorder: a nationwide population-based study","volume":"16","author":"Chong","year":"2018","journal-title":"J Transl Med"},{"issue":"8","key":"2024102107512809600_ocae182-B9","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.jamda.2015.03.013","article-title":"Aging and multimorbidity: new tasks, priorities, and frontiers for integrated gerontological and clinical research","volume":"16","author":"Fabbri","year":"2015","journal-title":"J Am Med Dir Assoc"},{"issue":"10","key":"2024102107512809600_ocae182-B10","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/s41576-021-00402-3","article-title":"Shared genetic components of multimorbidity","volume":"22","author":"Koch","year":"2021","journal-title":"Nat Rev Genet"},{"issue":"1","key":"2024102107512809600_ocae182-B11","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13073-021-00927-6","article-title":"A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank","volume":"13","author":"Dong","year":"2021","journal-title":"Genome Med"},{"issue":"1","key":"2024102107512809600_ocae182-B12","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s13643-021-01817-z","article-title":"Interventions for improving outcomes in patients with multimorbidity in primary care and community setting: a systematic review","volume":"10","author":"Smith","year":"2021","journal-title":"Syst Rev"},{"key":"2024102107512809600_ocae182-B13","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jclinepi.2018.09.008","article-title":"Multimorbidity and comorbidity revisited: refining the concepts for international health research","volume":"105","author":"Nicholson","year":"2019","journal-title":"J Clin Epidemiol"},{"issue":"Suppl 1","key":"2024102107512809600_ocae182-B14","first-page":"18","article-title":"Comorbidity and multimorbidity in medicine today: challenges and opportunities for bringing separated branches of medicine closer to each other","volume":"25","author":"Jakovljevi\u0107","year":"2013","journal-title":"Psychiatr Danub"},{"issue":"1","key":"2024102107512809600_ocae182-B15","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1016\/S2589-7500(22)00187-X","article-title":"Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study","volume":"5","author":"Kuan","year":"2023","journal-title":"Lancet Digit Health"},{"issue":"5","key":"2024102107512809600_ocae182-B16","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/sj.ejhg.5201585","article-title":"A text-mining analysis of the human phenome","volume":"14","author":"van Driel","year":"2006","journal-title":"Eur J Hum Genet"},{"issue":"9","key":"2024102107512809600_ocae182-B17","doi-asserted-by":"publisher","first-page":"e2232124","DOI":"10.1001\/jamanetworkopen.2022.32124","article-title":"Association of multimorbidity, disease clusters, and modification by genetic factors with risk of dementia","volume":"5","author":"Calvin","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"3","key":"2024102107512809600_ocae182-B18","doi-asserted-by":"publisher","first-page":"e1003931","DOI":"10.1371\/journal.pmed.1003931","article-title":"Associations between multimorbidity and adverse health outcomes in UK Biobank and the SAIL Databank: a comparison of longitudinal cohort studies","volume":"19","author":"Hanlon","year":"2022","journal-title":"PLoS Med"},{"key":"2024102107512809600_ocae182-B19","doi-asserted-by":"publisher","first-page":"103606","DOI":"10.1016\/j.jbi.2020.103606","article-title":"Learning multimorbidity patterns from electronic health records using non-negative matrix factorisation","volume":"112","author":"Hassaine","year":"2020","journal-title":"J Biomed Inform"},{"issue":"1","key":"2024102107512809600_ocae182-B20","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac780","article-title":"Interactive network-based clustering and investigation of multimorbidity association matrices with associationSubgraphs","volume":"39","author":"Strayer","year":"2023","journal-title":"Bioinformatics"},{"issue":"1","key":"2024102107512809600_ocae182-B21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s41109-018-0101-4","article-title":"Statistical methods for constructing disease comorbidity networks from longitudinal inpatient data","volume":"3","author":"Fotouhi","year":"2018","journal-title":"Appl Netw Sci"},{"issue":"1","key":"2024102107512809600_ocae182-B22","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1038\/s41598-020-59336-1","article-title":"MorbiNet: multimorbidity networks in adult general population. Analysis of type 2 diabetes mellitus comorbidity","volume":"10","author":"Aguado","year":"2020","journal-title":"Sci Rep"},{"issue":"3","key":"2024102107512809600_ocae182-B23","volume":"4","author":"Vessels"},{"key":"2024102107512809600_ocae182-B24","doi-asserted-by":"publisher","DOI":"10.1101\/2024.03.28.24305045","article-title":"Interoperability of phenome-wide multimorbidity patterns: a comparative study of two large-scale EHR systems","author":"Strayer","year":"2024","journal-title":"medRxiv"},{"issue":"4","key":"2024102107512809600_ocae182-B25","doi-asserted-by":"publisher","first-page":"e057017","DOI":"10.1136\/bmjopen-2021-057017","article-title":"Variation in the estimated prevalence of multimorbidity: systematic review and meta-analysis of 193 international studies","volume":"12","author":"Ho","year":"2022","journal-title":"BMJ Open"},{"key":"2024102107512809600_ocae182-B26","author":"Chang"},{"issue":"9","key":"2024102107512809600_ocae182-B27","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/bioinformatics\/btq126","article-title":"PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations","volume":"26","author":"Denny","year":"2010","journal-title":"Bioinformatics"},{"issue":"16","key":"2024102107512809600_ocae182-B28","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1093\/bioinformatics\/btu197","article-title":"R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment","volume":"30","author":"Carroll","year":"2014","journal-title":"Bioinformatics"},{"issue":"9","key":"2024102107512809600_ocae182-B29","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/aje\/kwx246","article-title":"Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population","volume":"186","author":"Fry","year":"2017","journal-title":"Am J Epidemiol"},{"issue":"5","key":"2024102107512809600_ocae182-B30","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1600-0447.2007.01095.x","article-title":"Physical illness and schizophrenia: a review of the literature","volume":"116","author":"Leucht","year":"2007","journal-title":"Acta Psychiatr Scand"},{"key":"2024102107512809600_ocae182-B31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.genhosppsych.2019.10.007","article-title":"Rates of hepatitis B and C in patients with schizophrenia: a meta-analysis","volume":"61","author":"Lluch","year":"2019","journal-title":"Gen Hosp Psychiatry"},{"issue":"1","key":"2024102107512809600_ocae182-B32","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S2215-0366(15)00357-0","article-title":"Prevalence of HIV, hepatitis B, and hepatitis C in people with severe mental illness: a systematic review and meta-analysis","volume":"3","author":"Hughes","year":"2016","journal-title":"Lancet Psychiatry"},{"issue":"40","key":"2024102107512809600_ocae182-B33","doi-asserted-by":"publisher","first-page":"E35517","DOI":"10.1097\/MD.0000000000035517","article-title":"The causal relationship of colorectal cancer on schizophrenia: a Mendelian randomization study","volume":"102","author":"Kim","year":"2023","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"2024102107512809600_ocae182-B34","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1038\/s41467-020-18492-8","article-title":"A shared genetic contribution to breast cancer and schizophrenia","volume":"11","author":"Lu","year":"2020","journal-title":"Nat Commun"},{"key":"2024102107512809600_ocae182-B35","first-page":"1368","article-title":"Risk of malignancy in patients with schizophrenia or bipolar disorder: nested case-control study","volume-title":"Arch Gen Psychiatry","author":"Hippisley-Cox","year":"2007"},{"issue":"1","key":"2024102107512809600_ocae182-B36","doi-asserted-by":"publisher","first-page":"26688","DOI":"10.1038\/srep26688","article-title":"Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"issue":"27","key":"2024102107512809600_ocae182-B37","doi-asserted-by":"publisher","first-page":"7329","DOI":"10.1073\/pnas.1510502113","article-title":"Characterizing treatment pathways at scale using the OHDSI network","volume":"113","author":"Hripcsak","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"2024102107512809600_ocae182-B38","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/nbt.2749","article-title":"Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data","volume":"31","author":"Denny","year":"2013","journal-title":"Nat Biotechnol"}],"container-title":["Journal of the American Medical Informatics Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jamia\/article-pdf\/31\/11\/2440\/59813495\/ocae182.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jamia\/article-pdf\/31\/11\/2440\/59813495\/ocae182.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T03:51:48Z","timestamp":1729482708000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jamia\/article\/31\/11\/2440\/7731425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,10]]},"references-count":38,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,8,10]]},"published-print":{"date-parts":[[2024,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jamia\/ocae182","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.07.23.23293047","asserted-by":"object"}]},"ISSN":["1067-5027","1527-974X"],"issn-type":[{"value":"1067-5027","type":"print"},{"value":"1527-974X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,8,10]]}}}