{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:24:33Z","timestamp":1765355073237,"version":"3.37.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"Abstract<\/jats:title>\n \n Significance<\/jats:title>\n Research on the conditions under which electronic cigarette (EC) use produces a net reduction in the population harm attributable to combusted cigarette (CC) use requires the triangulation of information from cohort(s) of smokers, non-smokers, EC users, and dual-users of all varieties.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n This project utilizes data from the All of Us Research Program to contrast a panel of wellness and disease-risk indicators across a range of self-reported tobacco-use profiles, including smokers, current, and former EC users. This article focuses on the tobacco use history and current tobacco use status among All of Us participants enrolled between May 2017 and February 2023 (Registered Controlled Tier Curated Data Repository [CDR] v7).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The present analytic sample included an unweighted total of N\u2009=\u2009412\u00a0211 individuals with information on ever-use of both CC and EC. Among them, 155\u00a0901 individuals have a history of CC use, with 65\u00a0206 identified as current smokers. EC usage is reported by 64\u00a0002 individuals, with 16\u00a0619 being current users. Model predicted analyses identified distinct patterns in CC and EC usage across demographic and socioeconomic variables, with younger ages favoring ECs.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Age was observed to significantly affect EC usage, and gender differences reveal that males were significantly more likely to use CC and\/or EC than females or African Americans of any gender. Higher educational achievement and income were associated with lower use of both CC and EC, while lower levels of mental health were observed to increase the likelihood of using CC and EC products.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Findings suggest the potential for the All of Us Research Program for investigation of causal factors driving both behavioral use transitions and cessation outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/jamia\/ocae237","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T10:50:09Z","timestamp":1725533409000},"page":"2829-2836","source":"Crossref","is-referenced-by-count":6,"title":["Cigarette smoking, e-cigarette use, and sociodemographic correlates of mental health and tobacco-related disease risk in the All of Us<\/i> Research Program"],"prefix":"10.1093","volume":"31","author":[{"given":"Thomas R","family":"Kirchner","sequence":"first","affiliation":[{"name":"Department of Social and Behavioral 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