{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T01:37:57Z","timestamp":1750815477137,"version":"3.30.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"12","funder":[{"name":"National Institutes of Health Office of Director","award":["3OT2OD035404-01S4"],"award-info":[{"award-number":["3OT2OD035404-01S4"]}]},{"name":"National Institutes of Health Office of Director","award":["3OT2OD031915-02S1"],"award-info":[{"award-number":["3OT2OD031915-02S1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The All of Us Research Program harnesses advances in technology, science, and engagement for precision medicine research. We describe informatics innovations which support that goal and return value to the participant cohort and community.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Research data from the All of Us Research Program are available to authorized users on the All of Us Researcher Workbench. We describe the technical infrastructure that enables data access and usage for researchers. Participants are considered partners. To ensure return of value, we outline participant access to information.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The All of Us Research Hub allows broad access to data, regardless of background. The innovations described are rooted in the program\u2019s core values: participation is open and reflects the diversity of the United States; participants are partners and have access to their information; transparency, security, and privacy are of the highest importance; data are broadly accessible; and the program promotes positive change. We assess research impact and reflect on how All of Us can increase existing return of value to participant communities through future informatics advancements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>The program will continue to support efforts to ensure equitable access to data and return of value to participants. Looking ahead, we invite the community to join us.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>All of Us research findings can change clinical care, inform guidelines, and set a new bar for data sharing. The ultimate return of value is better care for all.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jamia\/ocae264","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:41:39Z","timestamp":1733874099000},"page":"3042-3046","source":"Crossref","is-referenced-by-count":1,"title":["Informatics innovation to provide return of value to participant communities in the <i>All of Us<\/i> Research Program"],"prefix":"10.1093","volume":"31","author":[{"given":"Brandy M","family":"Mapes","sequence":"first","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]}]},{"given":"Rachele S","family":"Peterson","sequence":"additional","affiliation":[{"name":"All of Us Research Program, Office of the Director, National Institutes of Health , Bethesda, MD 20817,","place":["United States"]}]},{"given":"Karriem","family":"Watson","sequence":"additional","affiliation":[{"name":"All of Us Research Program, Office of the Director, National Institutes of Health , Bethesda, MD 20817,","place":["United States"]}]},{"given":"Melissa","family":"Basford","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]}]},{"given":"Elizabeth","family":"Cohn","sequence":"additional","affiliation":[{"name":"Institute of Health System Science, Feinstein Institutes for Medical Research , New Hyde Park, NY 11042,","place":["United States"]}]},{"given":"Paul A","family":"Harris","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]},{"name":"Department of Biomedical Informatics, Vanderbilt University Medical Center , Nashville, TN 37203,","place":["United States"]}]},{"given":"Joshua C","family":"Denny","sequence":"additional","affiliation":[{"name":"All of Us Research Program, Office of the Director, National Institutes of Health , Bethesda, MD 20817,","place":["United States"]}]}],"member":"286","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"2024121023405713700_ocae264-B1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJMsr1809937","article-title":"The \u201cAll of Us\u201d research program","volume":"381","author":"The All of Us Research Program Investigators","year":"2019","journal-title":"N Engl J Med"},{"key":"2024121023405713700_ocae264-B2","author":"Precision Medicine Initiative (PMI) Working Group","year":"2015"},{"key":"2024121023405713700_ocae264-B3","author":"All of Us Research Program | NIH","year":"2024"},{"key":"2024121023405713700_ocae264-B4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-biodatasci-122120-104825","article-title":"The All of Us data and research center: creating a secure, scalable, and sustainable ecosystem for biomedical research","volume":"6","author":"Mayo","year":"2023","journal-title":"Annu Rev Biomed Data Sci"},{"key":"2024121023405713700_ocae264-B5","author":"Informatics OHDS and the Book of OHDSI","year":"2024"},{"key":"2024121023405713700_ocae264-B6","author":"All of Us Researcher Workbench User Support","year":"2024"},{"key":"2024121023405713700_ocae264-B7","author":"Join All of Us | All of Us Research Program","year":"2024"},{"key":"2024121023405713700_ocae264-B8","doi-asserted-by":"crossref","first-page":"e068100","DOI":"10.1136\/bmjopen-2022-068100","article-title":"Integrating participants as partners in research governance and operations: an approach from the All of Us Research Program engagement core","volume":"13","author":"Hammack-Aviran","year":"2023","journal-title":"BMJ Open"},{"key":"2024121023405713700_ocae264-B9","doi-asserted-by":"crossref","first-page":"100570","DOI":"10.1016\/j.patter.2022.100570","article-title":"The All of Us Research Program: data quality, utility, and diversity","volume":"3","author":"Ramirez","year":"2022","journal-title":"Patterns (N Y)"},{"key":"2024121023405713700_ocae264-B10","author":"Researcher Workbench\u2014All of Us Research Hub","year":"2024"},{"key":"2024121023405713700_ocae264-B11","author":"All of Us Research Hub","year":"2024"},{"key":"2024121023405713700_ocae264-B12","author":"All of Us Research Program","year":"2024"},{"key":"2024121023405713700_ocae264-B13","author":"Using Games to Explore the Mind\u2014National Institute of Mental Health (NIMH)","year":"2024"},{"key":"2024121023405713700_ocae264-B14","doi-asserted-by":"crossref","first-page":"101163","DOI":"10.1016\/j.gim.2024.101163","article-title":"All of Us participant perspectives on the return of value in research","volume":"26","author":"Richmond","year":"2024","journal-title":"Genet Med"},{"key":"2024121023405713700_ocae264-B15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-022-01031-z","article-title":"Whole-genome sequencing as an investigational device for return of hereditary disease risk and pharmacogenomic results as part of the All of Us Research Program","volume":"14","author":"Venner","year":"2022","journal-title":"Genome Med"},{"key":"2024121023405713700_ocae264-B16","author":"All of Us Research Program | NIH","year":"2024"},{"key":"2024121023405713700_ocae264-B17","author":"Data Snapshots\u2014All of Us Research Hub","year":"2024"},{"key":"2024121023405713700_ocae264-B18","author":"Data Browser | All of Us Public Data Browser","year":"2024"},{"key":"2024121023405713700_ocae264-B19","article-title":"Returning value to the community through the All of Us Research Program data sandbox model","volume":"00","author":"Cohn","year":"2024","journal-title":"J Am Med Inform Assoc"},{"key":"2024121023405713700_ocae264-B20","doi-asserted-by":"crossref","first-page":"ocae167","DOI":"10.1093\/jamia\/ocae167","article-title":"Research to classrooms: a co-designed curriculum brings All of Us data to secondary schools","volume":"00","author":"Stark","year":"2024","journal-title":"J Am Med Inform Assoc"},{"key":"2024121023405713700_ocae264-B21","author":"Registered Institutions\u2014All of Us Research Hub","year":"2024"},{"key":"2024121023405713700_ocae264-B22","author":"Research Projects Directory\u2014All of Us Research Hub","year":"2024"},{"key":"2024121023405713700_ocae264-B23","author":"Publications\u2014All of Us Research Hub","year":"2024"},{"key":"2024121023405713700_ocae264-B24","author":"Public Health Genomics Knowledge Base","year":"2024"},{"key":"2024121023405713700_ocae264-B25","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ade9214","article-title":"Data-driven science and diversity in the All of Us Research Program","volume":"15","author":"Ginsburg","year":"2023","journal-title":"Sci Transl Med"},{"key":"2024121023405713700_ocae264-B26","author":"All of Us Research Program | NIH","year":"2024"},{"key":"2024121023405713700_ocae264-B27","author":"All of Us Research Program","year":"2024"},{"key":"2024121023405713700_ocae264-B28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41591-023-02744-3","article-title":"The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research","volume":"30","author":"Bianchi","year":"2024","journal-title":"Nat Med"},{"key":"2024121023405713700_ocae264-B29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41591-018-0307-0","article-title":"The practical implementation of artificial intelligence technologies in medicine","volume":"25","author":"He","year":"2019","journal-title":"Nat Med"}],"container-title":["Journal of the American Medical Informatics Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jamia\/article-pdf\/31\/12\/3042\/61000059\/ocae264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jamia\/article-pdf\/31\/12\/3042\/61000059\/ocae264.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:41:47Z","timestamp":1733874107000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jamia\/article\/31\/12\/3042\/7919351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,1]]},"references-count":29,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,9]]},"published-print":{"date-parts":[[2024,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jamia\/ocae264","relation":{},"ISSN":["1067-5027","1527-974X"],"issn-type":[{"value":"1067-5027","type":"print"},{"value":"1527-974X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,12,1]]}}}