{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:12:49Z","timestamp":1771891969709,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"name":"Veterans Affairs Merit Review","award":["I01CX001922"],"award-info":[{"award-number":["I01CX001922"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL130204"],"award-info":[{"award-number":["U01 HL130204"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Event capture in clinical trials is resource-intensive, and electronic medical records (EMRs) offer a potential solution. This study develops algorithms for EMR-based death and hospitalization capture and compares them with traditional event capture methods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>We compared the effectiveness of EMR-based event capture and site-captured events adjudicated by a clinical endpoint committee in the multi-center INfluenza Vaccine to Effectively Stop cardio Thoracic Events and Decompensated heart failure (INVESTED) trial for participants from the Veterans Affairs healthcare system. Varying time windows around event dates were used to optimize events matching. The algorithms were externally validated for heart failure hospitalizations in the Medical Information Mart for Intensive Care (MIMIC)-IV database.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We observed 100% sensitivity for death events with a 1-day window. Sensitivity for cardiovascular, heart failure, pulmonary, and nonspecific cardiopulmonary hospitalizations using discharge diagnosis codes varied between 75% and 95%. Including Centers for Medicare &amp; Medicaid Services data improved sensitivity with no meaningful decrease in specificity. The MIMIC-IV analysis showed 82% sensitivity and 99% specificity for heart failure hospitalizations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>EMR-based method accurately identifies all-cause mortality and demonstrates high accuracy for cardiopulmonary hospitalizations. This study underscores the importance of optimal time windows, data completeness, and domain variability in EMR systems.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>EMR-based methods are effective strategies for capturing death and hospitalizations in clinical trials; however, their effectiveness may be influenced by the complexity of events and domain variability across different EMR systems. Nonetheless, EMR-based methods can serve as a valuable complement to traditional methods.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jamia\/ocae303","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T18:34:36Z","timestamp":1734114876000},"page":"349-356","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of electronic medical record-based strategies for death and hospital admission endpoint capture in pragmatic clinical trials"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8714-0141","authenticated-orcid":false,"given":"Maryam","family":"Rahafrooz","sequence":"first","affiliation":[{"name":"VA Providence Healthcare System , Providence, RI 02908,","place":["United States"]},{"name":"The Warren Alpert School of Medicine, Brown University , Providence, RI 02903,","place":["United 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Healthcare System , Providence, RI 02908,","place":["United States"]}]},{"given":"Cenk","family":"Yildirim","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, MA 02130,","place":["United States"]}]},{"given":"Akshay S","family":"Desai","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA 02115,","place":["United States"]},{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115,","place":["United States"]}]},{"given":"Abigail A","family":"Santos","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, MA 02130,","place":["United States"]}]},{"given":"Karen","family":"Murray","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, MA 02130,","place":["United States"]}]},{"given":"Thomas","family":"Havighurst","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, University of Wisconsin , Madison, WI 53726,","place":["United States"]}]},{"given":"Jacob A","family":"Udell","sequence":"additional","affiliation":[{"name":"Women\u2019s College Hospital , Toronto, ON M5S 1B2,","place":["Canada"]},{"name":"Peter Munk Cardiac Centre, University Health Network , Toronto, ON M5G 2N2,","place":["Canada"]},{"name":"University of Toronto , Toronto, ON M5S 1A1,","place":["Canada"]}]},{"given":"Michael E","family":"Farkouh","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Health System , Los Angeles, CA 90048,","place":["United States"]}]},{"given":"Lawton","family":"Cooper","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA 02115,","place":["United States"]},{"name":"National Heart Lung and Blood Institute, National Institute of Health , Bethesda, MD 20892,","place":["United States"]}]},{"given":"J Michael","family":"Gaziano","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, MA 02130,","place":["United 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