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GARDE-Chat is an open-source platform designed to facilitate the development, deployment, and dissemination of chatbot-based digital health interventions across different domains and settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>GARDE-Chat was developed through an iterative process informed by real-world use cases to guide prioritization of key features. The tool was developed as an open-source platform to promote collaboration, broad dissemination, and impact across research and clinical domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GARDE-Chat\u2019s main features include (1) a visual authoring interface that allows non-programmers to design chatbots; (2) support for scripted, large language model (LLM)-based and hybrid chatbots; (3) capacity to share chatbots with researchers and institutions; (4) integration with external applications and data sources such as electronic health records and REDCap; (5) delivery via web browsers or text messaging; and (6) detailed audit log supporting analyses of chatbot user interactions. Since its first release in July 2022, GARDE-Chat has supported the development of chatbot-based interventions tested in multiple studies, including large pragmatic clinical trials addressing topics such as genetic testing, COVID-19 testing, tobacco cessation, and cancer screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Ongoing challenges include the effort required for developing chatbot scripts, ensuring safe use of LLMs, and integrating with clinical systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GARDE-Chat is a generalizable platform for creating, implementing, and disseminating scalable chatbot-based population health interventions. It has been validated in several studies, and it is available to researchers and healthcare systems through an open-source mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jamia\/ocaf211","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T13:07:57Z","timestamp":1763125677000},"page":"593-602","source":"Crossref","is-referenced-by-count":1,"title":["GARDE-Chat: a scalable, open-source platform for building and deploying health chatbots"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-6799","authenticated-orcid":false,"given":"Guilherme","family":"Del Fiol","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics, University of Utah , Salt Lake City, UT 84108,","place":["United States"]}]},{"given":"Emerson","family":"Borsato","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Utah , Salt Lake City, UT 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