{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:35:02Z","timestamp":1777991702595,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100026882","name":"Tell Every Amazing Lady","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100026882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Accurate phenotyping is an essential task for researchers utilizing electronic health record (EHR)-linked biobank programs like the All of Us Research Program to study human genetics. However, little guidance is available on how to select an EHR-based phenotyping procedure that maximizes downstream statistical power. This study aims to estimate accuracy of three phenotype definitions of ovarian, female breast, and colorectal cancers in All of Us (v7 release) and determine which is most likely to optimize downstream statistical power for genetic association testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We used empirical carrier frequencies of deleterious variants in known risk genes to estimate the accuracy of each phenotype definition and compute statistical power after accounting for the probability of outcome misclassification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that the choice of phenotype definition can have a substantial impact on statistical power for association testing and that no approach was optimal across all tested diseases. The impact on power was particularly acute for rarer diseases and target risk alleles of moderate penetrance or low frequency. Additionally, our results suggest that the accuracy of higher-complexity phenotyping algorithms is inconsistent across Black and non-Hispanic White participants in All of Us, highlighting the potential for case ascertainment biases to impact downstream association testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>EHR-based phenotyping presents a bottleneck for maximizing power to detect novel risk alleles in All of Us, as well as a potential source of differential outcome misclassification that researchers should be aware of. We discuss the implications of this as well as potential mitigation strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jamia\/ocaf234","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T12:22:44Z","timestamp":1767442964000},"page":"611-620","source":"Crossref","is-referenced-by-count":1,"title":["Measuring the accuracy of electronic health record-based phenotyping in the\n                    <i>All of Us<\/i>\n                    Research Program to optimize statistical power for genetic association testing"],"prefix":"10.1093","volume":"33","author":[{"given":"John","family":"Baierl","sequence":"first","affiliation":[{"name":"Department of Computational Biomedicine, Cedars Sinai Medical Center , Los Angeles, CA 90048,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Wen","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Computational Biomedicine, Cedars 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