{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:48:00Z","timestamp":1777355280540,"version":"3.51.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":186,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Google Faculty Research Award","award":["UL1 TR000038"],"award-info":[{"award-number":["UL1 TR000038"]}]},{"name":"National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Eleanor and Miles Shore Foundation, and Center for Integration of Medicine and Innovative Technology","award":["12-1262"],"award-info":[{"award-number":["12-1262"]}]},{"name":"US Army Medical Research Acquisition Activity Cooperative Agreement","award":["W81XWH-09-2-0001"],"award-info":[{"award-number":["W81XWH-09-2-0001"]}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Background Electronic medical records (EMRs) hold a tremendous amount of information about patients that is relevant to determining the optimal approach to patient care. As medicine becomes increasingly precise, a patient\u2019s electronic medical record phenotype will play an important role in triggering clinical decision support systems that can deliver personalized recommendations in real time. Learning with anchors presents a method of efficiently learning statistically driven phenotypes with minimal manual intervention.<\/jats:p><jats:p>Materials and Methods We developed a phenotype library that uses both structured and unstructured data from the EMR to represent patients for real-time clinical decision support. Eight of the phenotypes were evaluated using retrospective EMR data on emergency department patients using a set of prospectively gathered gold standard labels.<\/jats:p><jats:p>Results We built a phenotype library with 42 publicly available phenotype definitions. Using information from triage time, the phenotype classifiers have an area under the ROC curve (AUC) of infection 0.89, cancer 0.88, immunosuppressed 0.85, septic shock 0.93, nursing home 0.87, anticoagulated 0.83, cardiac etiology 0.89, and pneumonia 0.90. Using information available at the time of disposition from the emergency department, the AUC values are infection 0.91, cancer 0.95, immunosuppressed 0.90, septic shock 0.97, nursing home 0.91, anticoagulated 0.94, cardiac etiology 0.92, and pneumonia 0.97.<\/jats:p><jats:p>Discussion The resulting phenotypes are interpretable and fast to build, and perform comparably to statistically learned phenotypes developed with 5000 manually labeled patients.<\/jats:p><jats:p>Conclusion Learning with anchors is an attractive option for building a large public repository of phenotype definitions that can be used for a range of health IT applications, including real-time decision support.<\/jats:p>","DOI":"10.1093\/jamia\/ocw011","type":"journal-article","created":{"date-parts":[[2016,4,24]],"date-time":"2016-04-24T00:18:19Z","timestamp":1461457099000},"page":"731-740","source":"Crossref","is-referenced-by-count":120,"title":["Electronic medical record phenotyping using the anchor and learn 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