{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:41:18Z","timestamp":1773927678858,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Information Systems Department at Memorial Sloan Kettering Cancer Center developed the DARWIN Cohort Management System (DCMS). The DCMS identifies and tracks cohorts of patients based on genotypic and clinical data. It assists researchers and treating physicians in enrolling patients to genotype-matched IRB-approved clinical trials. The DCMS sends automated, actionable, and secure email notifications to users with information about eligible or enrolled patients before their upcoming appointments. The system also captures investigators input via annotations on patient eligibility and preferences on future status updates. As of August 2015, the DCMS is tracking 159,893 patients on both clinical operations and research cohorts. 134 research cohorts have been established and track 64,473 patients. 51,192 of these have had one or more genomic tests including MSK-IMPACT, comprising the pool eligible for genotype-matched studies. This paper describes the design and evolution of this Informatics solution.<\/jats:p>","DOI":"10.1093\/jamia\/ocw020","type":"journal-article","created":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T00:12:26Z","timestamp":1459037546000},"page":"777-781","source":"Crossref","is-referenced-by-count":32,"title":["Automated eligibility screening and monitoring for genotype-driven precision oncology trials"],"prefix":"10.1093","volume":"23","author":[{"given":"Michael H","family":"Eubank","sequence":"first","affiliation":[{"name":"Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Hyman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amritha D","family":"Kanakamedala","sequence":"additional","affiliation":[{"name":"Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart M","family":"Gardos","sequence":"additional","affiliation":[{"name":"Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M","family":"Wills","sequence":"additional","affiliation":[{"name":"Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D","family":"Stetson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"},{"name":"Division of Health Informatics, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,3,25]]},"reference":[{"issue":"6","key":"2020110612353314200_ocw020-B1","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1200\/JCO.2001.19.6.1728","article-title":"Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment","volume":"19","author":"Lara","year":"2001","journal-title":"J Clin Oncol."},{"issue":"6","key":"2020110612353314200_ocw020-B2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1200\/JOP.2012.000646","article-title":"Effort required in eligibility screening for clinical trials","volume":"8","author":"Penberthy","year":"2012","journal-title":"J Oncol Practice."},{"issue":"e1","key":"2020110612353314200_ocw020-B3","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1093\/jamia\/ocu050","article-title":"Case-based reasoning using electronic health records efficiently identifies eligible patients for clinical trials","volume":"22","author":"Miotto","year":"2015","journal-title":"J Am Med Inform Assoc."},{"key":"2020110612353314200_ocw020-B4","doi-asserted-by":"crossref","DOI":"10.1186\/s12911-015-0149-3","article-title":"Increasing the efficiency of trial-patient matching: automated clinical trial eligibility pre-screening for pediatric oncology patients","author":"Ni","year":"2015","journal-title":"BMC MedI Inform Dec Mak."},{"issue":"1-2","key":"2020110612353314200_ocw020-B5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0933-3657(03)00040-X","article-title":"Using OncoDoc as a computer-based eligibility screening system to improve accrual onto breast cancer clinical trials","volume":"29","author":"Seroussi","year":"2003","journal-title":"Artificial Intel Med."},{"issue":"e1","key":"2020110612353314200_ocw020-B6","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1136\/amiajnl-2011-000508","article-title":"Practices and perspectives on building integrated data repositories: results from a 2010 CTSA survey","volume":"19","author":"MacKenzie","year":"2012","journal-title":"J Am Med Inform Assoc."},{"issue":"4","key":"2020110612353314200_ocw020-B7","doi-asserted-by":"crossref","first-page":"e35309","DOI":"10.1371\/journal.pone.0035309","article-title":"Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials","volume":"7","author":"Lovly","year":"2012","journal-title":"PloS One."},{"issue":"25","key":"2020110612353314200_ocw020-B8","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1200\/JCO.2014.60.4165","article-title":"Feasibility of large-scale genomic testing to facilitate enrollment onto genomically matched clinical trials","volume":"33","author":"Meric-Bernstam","year":"2015","journal-title":"J Clin Oncol."},{"key":"2020110612353314200_ocw020-B9","article-title":"Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease","author":"Committee on a Framework for Development a New Taxonomy of Disease (National Research Council)","year":"2011"},{"issue":"15","key":"2020110612353314200_ocw020-B10","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1200\/JCO.2013.49.4799","article-title":"Precision oncology: an overview","volume":"31","author":"Garraway","year":"2013","journal-title":"J Clin Oncol."},{"issue":"25","key":"2020110612353314200_ocw020-B11","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1200\/JCO.2015.61.9296","article-title":"Tumor genetic screening programs: a call to action","volume":"33","author":"Hyman","year":"2015","journal-title":"J Clin Oncol."},{"issue":"3","key":"2020110612353314200_ocw020-B12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jmoldx.2014.12.006","article-title":"Memorial Sloan Kettering\u2013Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology","volume":"17","author":"Cheng","year":"2015","journal-title":"J Mol Diagnostics."},{"issue":"2","key":"2020110612353314200_ocw020-B13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.path.2015.02.015","article-title":"Translational Bioinformatics and Clinical Research (Biomedical) Informatics","volume":"8","author":"Sirintrapun","year":"2015","journal-title":"Surg Pathol Clinics."},{"issue":"4","key":"2020110612353314200_ocw020-B14","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv003","article-title":"Application of molecular profiling in clinical trials for advanced metastatic cancers","volume":"107","author":"Kummar","year":"2015","journal-title":"J Natl Cancer Inst."},{"issue":"8","key":"2020110612353314200_ocw020-B15","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1056\/NEJMoa1502309","article-title":"Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 mutations","volume":"373","author":"Hyman","year":"2015","journal-title":"New Engl J Med."},{"issue":"8","key":"2020110612353314200_ocw020-B16","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1056\/NEJMp1508144","article-title":"D'Agostino RB, Sr. Let's Not Put All Our Eggs in One Basket","volume":"373","author":"Hunter","year":"2015","journal-title":"New Engl J Med."},{"issue":"269","key":"2020110612353314200_ocw020-B17","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci Signal."}],"container-title":["Journal of the American Medical Informatics Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jamia\/article\/23\/4\/777\/2200342","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jamia\/article\/23\/4\/777\/2200342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T17:36:56Z","timestamp":1604684216000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jamia\/article\/23\/4\/777\/2200342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,25]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,3,25]]},"published-print":{"date-parts":[[2016,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jamia\/ocw020","relation":{},"ISSN":["1527-974X","1067-5027"],"issn-type":[{"value":"1527-974X","type":"electronic"},{"value":"1067-5027","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,7]]},"published":{"date-parts":[[2016,3,25]]}}}