{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:47:32Z","timestamp":1772783252826,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-R01-EB017205"],"award-info":[{"award-number":["NIH-R01-EB017205"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-R01-EB001659"],"award-info":[{"award-number":["NIH-R01-EB001659"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Lack of reproducibility in medical studies is a barrier to the generation of a robust knowledge base to support clinical decision-making. In this paper we outline the Medical Information Mart for Intensive Care (MIMIC) Code Repository, a centralized code base for generating reproducible studies on an openly available critical care dataset.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Code is provided to load the data into a relational structure, create extractions of the data, and reproduce entire analysis plans including research studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Concepts extracted include severity of illness scores, comorbid status, administrative definitions of sepsis, physiologic criteria for sepsis, organ failure scores, treatment administration, and more. Executable documents are used for tutorials and reproduce published studies end-to-end, providing a template for future researchers to replicate. The repository\u2019s issue tracker enables community discussion about the data and concepts, allowing users to collaboratively improve the resource.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>The centralized repository provides a platform for users of the data to interact directly with the data generators, facilitating greater understanding of the data. It also provides a location for the community to collaborate on necessary concepts for research progress and share them with a larger audience. Consistent application of the same code for underlying concepts is a key step in ensuring that research studies on the MIMIC database are comparable and reproducible.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>By providing open source code alongside the freely accessible MIMIC-III database, we enable end-to-end reproducible analysis of electronic health records.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jamia\/ocx084","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T19:12:43Z","timestamp":1501182763000},"page":"32-39","source":"Crossref","is-referenced-by-count":345,"title":["The MIMIC Code Repository: enabling reproducibility in critical care research"],"prefix":"10.1093","volume":"25","author":[{"given":"Alistair E W","family":"Johnson","sequence":"first","affiliation":[{"name":"Massachusetts Institute of Technology, Cambridge, MA, USA"}]},{"given":"David J","family":"Stone","sequence":"additional","affiliation":[{"name":"University of Virginia School of Medicine, Charlottesville, VA, USA"}]},{"given":"Leo A","family":"Celi","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology, Cambridge, MA, USA"},{"name":"Beth Israel Deaconess Medical Center, Boston, MA, USA"}]},{"given":"Tom J","family":"Pollard","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology, Cambridge, MA, USA"}]}],"member":"286","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"issue":"1","key":"2020110612455058000_ocx084-B1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/533452a","article-title":"1,500 scientists lift the lid on reproducibility","volume":"533","author":"Baker","year":"2016","journal-title":"Nature."},{"key":"2020110612455058000_ocx084-B2","first-page":"0","article-title":"Healthcare The power of capturing and using information at the point of care","volume":"January","author":"Gruber","year":"2016","journal-title":"Healthcare [Internet]"},{"key":"2020110612455058000_ocx084-B3","first-page":"3","article-title":"MIMIC-III, a freely accessible critical care database","author":"Johnson","year":"2016","journal-title":"Scientific Data."},{"key":"2020110612455058000_ocx084-B4","volume-title":"The MIMIC-III Clinical Database","author":"Pollard"},{"key":"2020110612455058000_ocx084-B5","volume-title":"MIT-LCP\/mimic-code: MIMIC-III v1.4","author":"Pollard","year":"2017"},{"issue":"1","key":"2020110612455058000_ocx084-B6","doi-asserted-by":"crossref","first-page":"e1001745","DOI":"10.1371\/journal.pbio.1001745","article-title":"Best practices for scientific computing","volume":"12","author":"Wilson","year":"2014","journal-title":"PLOS Biol [Internet]."},{"issue":"1","key":"2020110612455058000_ocx084-B7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/archsurg.137.1.37","article-title":"APACHE 1978\u20132001: the development of a quality assurance system based on prognosis: milestones and personal reflections","volume":"137","author":"Knaus","year":"2002","journal-title":"Arch Surg."},{"issue":"6","key":"2020110612455058000_ocx084-B8","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1378\/chest.100.6.1619","article-title":"The APACHE III prognostic system: Risk prediction of hospital mortality for critically ill hospitalized adults","volume":"100","author":"Knaus","year":"1991","journal-title":"Chest."},{"issue":"24","key":"2020110612455058000_ocx084-B9","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","article-title":"A new simplified acute physiology score (SAPS II) based on a European\/North American multicenter study","volume":"270","author":"Le Gall","year":"1993","journal-title":"JAMA."},{"issue":"10","key":"2020110612455058000_ocx084-B10","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/jama.1996.03540100046027","article-title":"The Logistic Organ Dysfunction system. 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