{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:27:39Z","timestamp":1764174459178,"version":"3.37.3"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,1,6]],"date-time":"2018-01-06T00:00:00Z","timestamp":1515196800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HG006492","K08CA188615"],"award-info":[{"award-number":["U01HG006492","K08CA188615"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["120529-MRSG-11-006-01-CPPB"],"award-info":[{"award-number":["120529-MRSG-11-006-01-CPPB"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Misinterpretation of complex genomic data presents a major challenge in the implementation of precision oncology. We sought to determine whether interactive genomic reports with embedded clinician education and optimized data visualization improved genomic data interpretation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We conducted a randomized, vignette-based survey study to determine whether exposure to interactive reports for a somatic gene panel, as compared to static reports, improves physicians\u2019 genomic comprehension and report-related satisfaction (overall scores calculated across 3 vignettes, range 0\u201318 and 1\u20134, respectively, higher score corresponding with improved endpoints).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and five physicians at a tertiary cancer center participated (29% participation rate): 67% medical, 20% pediatric, 7% radiation, and 7% surgical oncology; 37% female. Prior to viewing the case-based vignettes, 34% of the physicians reported difficulty making treatment recommendations based on the standard static report. After vignette\/report exposure, physicians\u2019 overall comprehension scores did not differ by report type (mean score: interactive 11.6 vs static 10.5, difference\u2009=\u20091.1, 95% CI, \u22120.3, 2.5, P\u2009=\u2009.13). However, physicians exposed to the interactive report were more likely to correctly assess sequencing quality (P\u2009&amp;lt;\u2009.001) and understand when reports needed to be interpreted with caution (eg, low tumor purity; P\u2009=\u2009.02). Overall satisfaction scores were higher in the interactive group (mean score 2.5 vs 2.1, difference\u2009=\u20090.4, 95% CI, 0.2-0.7, P\u2009=\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>Interactive genomic reports may improve physicians\u2019 ability to accurately assess genomic data and increase report-related satisfaction. Additional research in users\u2019 genomic needs and efforts to integrate interactive reports into electronic health records may facilitate the implementation of precision oncology.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jamia\/ocx150","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T04:09:14Z","timestamp":1512187754000},"page":"458-464","source":"Crossref","is-referenced-by-count":13,"title":["Interactive or static reports to guide clinical interpretation of cancer genomics"],"prefix":"10.1093","volume":"25","author":[{"given":"Stacy W","family":"Gray","sequence":"first","affiliation":[{"name":"City of Hope Comprehensive Cancer Center, Duarte, CA, USA"},{"name":"Beckman Research Institute, Duarte, CA, USA"}]},{"given":"Jeffrey","family":"Gagan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"}]},{"given":"Ethan","family":"Cerami","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA"}]},{"given":"Angel M","family":"Cronin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"}]},{"given":"Hajime","family":"Uno","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"}]},{"given":"Nelly","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"}]},{"given":"Carol","family":"Lowenstein","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"}]},{"given":"Ruth","family":"Lederman","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"}]},{"given":"Anna","family":"Revette","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"}]},{"given":"Aaron","family":"Suarez","sequence":"additional","affiliation":[{"name":"The Broad Institute, Cambridge, MA, USA"}]},{"given":"Charlotte","family":"Lee","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"}]},{"given":"Jordan","family":"Bryan","sequence":"additional","affiliation":[{"name":"The Broad Institute, Cambridge, MA, USA"}]},{"given":"Lynette","family":"Sholl","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"}]},{"given":"Eliezer M","family":"Van 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