{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:26:02Z","timestamp":1769005562411,"version":"3.49.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To extract drug indications from a commercial drug knowledgebase and determine to what extent drug indications can discriminate between look-alike-sound-alike (LASA) drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We extracted drug indications disease concepts from the MedKnowledge Indications module from First Databank Inc. (South San Francisco, CA) and associated them with drugs on the Institute for Safe Medication Practices (ISMP) list of commonly confused drug names. We used high-level concepts (rather than granular concepts) to represent the general indications for each drug. Two pharmacists reviewed each drug\u2019s association with its high-level indications concepts for accuracy and clinical relevance. We compared the high-level indications for each commonly confused drug pair and categorized each pair as having a complete overlap, partial overlap or no overlap in high-level indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 278 LASA drug pairs, 165 (59%) had no overlap and 58 (21%) had partial overlap in high-level indications. Fifty-five pairs (20%) had complete overlap in high-level indications; nearly half of these were comprised of drugs with the same active ingredient and route of administration (e.g., Adderall, Adderall XR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Drug indications data from a drug knowledgebase can discriminate between many LASA drugs.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jamia\/ocy043","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T05:52:24Z","timestamp":1522993944000},"page":"872-884","source":"Crossref","is-referenced-by-count":8,"title":["Using drug knowledgebase information to distinguish between look-alike-sound-alike drugs"],"prefix":"10.1093","volume":"25","author":[{"given":"Christine M","family":"Cheng","sequence":"first","affiliation":[{"name":"First Databank, Inc., Disease Decision Support Group, South San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Salazar","sequence":"additional","affiliation":[{"name":"Division of General Medicine and Primary Care, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary G","family":"Amato","sequence":"additional","affiliation":[{"name":"Division of General Medicine and Primary Care, Brigham and Women\u2019s Hospital, Boston, MA, USA"},{"name":"Department of Pharmacy Practice, MCPHS University, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce L","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Communication Studies, Northwestern University, Chicago, IL, USA"},{"name":"Center for Communication and Health, Northwestern University, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn A","family":"Volk","sequence":"additional","affiliation":[{"name":"Clinical and Quality Analysis, Partners HealthCare, Somerville, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2821-3994","authenticated-orcid":false,"given":"Gordon D","family":"Schiff","sequence":"additional","affiliation":[{"name":"Division of General Medicine and Primary Care, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"issue":"7","key":"2020110612364167200_ocy043-B1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2165\/00002018-200326070-00001","article-title":"Medication errors caused by confusion of drug names","volume":"26","author":"Hoffman","year":"2003","journal-title":"Drug Saf"},{"key":"2020110612364167200_ocy043-B2","volume-title":"MEDMARX Data Report: A Report on the Relationship of Drug Names and 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