{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:28:04Z","timestamp":1762507684108,"version":"3.37.3"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OT3TR002020","OT2TR002514"],"award-info":[{"award-number":["OT3TR002020","OT2TR002514"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"North Carolina Translational and Clinical Sciences Institute"},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002489"],"award-info":[{"award-number":["UL1TR002489"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to develop a novel, regulatory-compliant approach for openly exposing integrated clinical and environmental exposures data: the Integrated Clinical and Environmental Exposures Service (ICEES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The driving clinical use case for research and development of ICEES was asthma, which is a common disease influenced by hundreds of genes and a plethora of environmental exposures, including exposures to airborne pollutants. We developed a pipeline for integrating clinical data on patients with asthma-like conditions with data on environmental exposures derived from multiple public data sources. The data were integrated at the patient and visit level and used to create de-identified, binned, \u201cintegrated feature tables,\u201d which were then placed behind an OpenAPI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our preliminary evaluation results demonstrate a relationship between exposure to high levels of particulate matter \u22642.5 \u00b5m in diameter (PM2.5) and the frequency of emergency department or inpatient visits for respiratory issues. For example, 16.73% of patients with average daily exposure to PM2.5 &amp;gt;9.62 \u00b5g\/m3 experienced 2 or more emergency department or inpatient visits for respiratory issues in year 2010 compared with 7.93% of patients with lower exposures (n\u2009=\u200923 093).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The results validated our overall approach for openly exposing and sharing integrated clinical and environmental exposures data. We plan to iteratively refine and expand ICEES by including additional years of data, feature variables, and disease cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We believe that ICEES will serve as a regulatory-compliant model and approach for promoting open access to and sharing of integrated clinical and environmental exposures data.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jamia\/ocz042","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T20:22:28Z","timestamp":1553545348000},"page":"1064-1073","source":"Crossref","is-referenced-by-count":23,"title":["A novel approach for exposing and sharing clinical data: the Translator Integrated Clinical and Environmental Exposures Service"],"prefix":"10.1093","volume":"26","author":[{"given":"Karamarie","family":"Fecho","sequence":"first","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}]},{"given":"Emily","family":"Pfaff","sequence":"additional","affiliation":[{"name":"North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}]},{"given":"James","family":"Champion","sequence":"additional","affiliation":[{"name":"North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}]},{"given":"Steve","family":"Cox","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}]},{"given":"Lisa","family":"Stillwell","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}]},{"given":"David B","family":"Peden","sequence":"additional","affiliation":[{"name":"North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"},{"name":"Division of Allergy, Immunology and Rheumatology, Center for Environmental Medicine, Asthma & Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"},{"name":"Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}]},{"given":"Chris","family":"Bizon","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}]},{"given":"Ashok","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"},{"name":"North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}]},{"given":"Alexander","family":"Tropsha","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"},{"name":"School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}]},{"given":"Stanley C","family":"Ahalt","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"},{"name":"North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 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