{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T04:01:04Z","timestamp":1744689664807,"version":"3.40.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Young Scientist Grants-Outstanding Track","award":["NRF-2021R1C1C1011494"],"award-info":[{"award-number":["NRF-2021R1C1C1011494"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2023R1A2C1003876"],"award-info":[{"award-number":["NRF-2023R1A2C1003876"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Efforts have been made to improve the prediction of implant treatment outcomes through biomechanical analyses using finite-element (FE) analysis. Particularly, a bone remodelling numerical model has been recently applied to forecast long-term stability. However, there is a scarcity of research on the long-term biomechanical stability of implant-supported bridges. This study investigates the impact of integrating a bone remodelling numerical model into FE analysis to evaluate the biomechanical stability of mandibular implant-supported bridges. To evaluate the impact of integrated bone remodelling, FE analyses were performed with and without a bone remodelling model. The bone remodelling model was implemented in Abaqus as a user subroutine, UMAT, used to define a mechanical behaviour of material. Cases were compared based on the number of fixtures used in the implant-supported bridges and the initial bone quality to assess risks in different treatment scenarios. The peri-implant bone density distribution ultimately showed higher values than the initial value after bone remodelling. The study analysed differences in microstrain proportions within the peri-implant bone, with and without bone remodelling, following simulated masticatory activity. Absence of bone remodelling consideration results in elevated microstrain, especially among elderly patients with fewer implants and in the second molar position. This omission leads to an overestimation of differences in high microstrain proportion based on implant position (senior, Group 1: 18.91%p) and number of implants (senior, second molar: 13.8%p). Initial bone quality has a significant influence on bone remodelling. The absence of long-term analysis exaggerates the risks for all considered cases. This study emphasizes the importance of incorporating bone remodelling considerations into the stability analysis of implant-supported bridges, particularly when they are used with fewer implants and for elderly patients.<\/jats:p>","DOI":"10.1093\/jcde\/qwaf005","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T12:09:51Z","timestamp":1736597391000},"page":"14-26","source":"Crossref","is-referenced-by-count":1,"title":["Impact of considering bone remodelling in risk assessment of mandibular implant-supported bridges"],"prefix":"10.1093","volume":"12","author":[{"given":"Inyeong","family":"Kang","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering, Korea University , Seoul 02841 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngjae","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry, Kyung Hee University , Seoul 02447 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soyeon","family":"Park","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Korea University , Seoul 02841 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Dae","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry, Kyung Hee University , Seoul 02447 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunwoo","family":"Noh","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Korea University , Seoul 02841 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"2025041407274132900_bib1","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1902\/jop.2013.120713","article-title":"Influence of tapered and external hexagon connections on bone stresses around tilted dental implants: three-dimensional finite element method with statistical analysis","volume":"85","author":"Almeida","year":"2014","journal-title":"Journal of Periodontology"},{"key":"2025041407274132900_bib2","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.prosdent.2004.09.018","article-title":"Long-term treatment outcomes in edentulous patients with implant overdentures: The Toronto Study","volume":"93","author":"Attard","year":"2005","journal-title":"The Journal of Prosthetic Dentistry"},{"key":"2025041407274132900_bib3","doi-asserted-by":"publisher","first-page":"105723","DOI":"10.1016\/j.cmpb.2020.105723","article-title":"Effect of different impactor designs on biomechanical behavior in the interface bone-implant: A comparative biomechanics study","volume":"197","author":"Bachiri","year":"2020","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"2025041407274132900_bib4","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1093\/jcde\/qwaa053","article-title":"Design and numerical investigation of an adaptive intramedullary nail with a novel interlocking mechanism","volume":"7","author":"Bagheri","year":"2020","journal-title":"Journal of Computational Design and Engineering"},{"key":"2025041407274132900_bib5","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.jbiomech.2013.02.008","article-title":"Comparison of different designs of implant-retained overdentures and fixed full-arch implant-supported prosthesis on stress distribution in edentulous mandible\u2013a computed tomography-based three-dimensional finite element analysis","volume":"46","author":"Barao","year":"2013","journal-title":"Journal of Biomechanics"},{"key":"2025041407274132900_bib6","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s10237-010-0274-y","article-title":"Modeling of bone adaptative behavior based on cells activities","volume":"10","author":"Bonfoh","year":"2011","journal-title":"Biomechanics and Modeling in Mechanobiology"},{"key":"2025041407274132900_bib7","first-page":"101","article-title":"Maximum occlusal force levels in patients with osseointegrated oral implant prostheses and patients with complete dentures","volume":"2","author":"Carr","year":"1987","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"2025041407274132900_bib8","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1007\/s40846-022-00729-0","article-title":"Stress distribution of four-unit implant-supported fixed partial prosthesis with different numbers and positions of fixtures in maxilla anterior region-3D FEA","volume":"42","author":"Cheng","year":"2022","journal-title":"Journal of Medical and Biological Engineering"},{"key":"2025041407274132900_bib9","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.medengphy.2006.10.017","article-title":"Biomechanical study of a prosthetic solution based on an angled abutment: Case of upper lateral incisor [Article]","volume":"29","author":"Dubois","year":"2007","journal-title":"Medical Engineering & Physics"},{"key":"2025041407274132900_bib10","first-page":"55","article-title":"Occlusal force pattern in dentitions with mandibular implant-supported fixed cantilever prostheses occluded with complete dentures","volume":"4","author":"Falk","year":"1989","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"2025041407274132900_bib11","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1002\/ar.a.10119","article-title":"Bone's mechanostat: A 2003 update [Review]","volume":"275A","author":"Frost","year":"2003","journal-title":"Anatomical Record Part a-Discoveries in Molecular Cellular and Evolutionary Biology"},{"key":"2025041407274132900_bib12","doi-asserted-by":"crossref","unstructured":"Gholamalizadeh T., Moshfeghifar F., Ferguson Z., Schneider T., Panozzo D., Darkner S., Makaremi M., Chan F., S\u00f8ndergaard L. P., Erleben K. (2022). Open-Full-Jaw: An open-access dataset and pipeline for finite element models of human jaw. Computer Methods and Programs in Biomedicine, 224, 107009. 10.1016\/j.cmpb.2022.107009","DOI":"10.1016\/j.cmpb.2022.107009"},{"key":"2025041407274132900_bib13","doi-asserted-by":"publisher","first-page":"107178","DOI":"10.1016\/j.cmpb.2022.107178","article-title":"The practicability of different preparation of mandibular molar restored by modified endocrown with intracanal extension: computational analysis using finite element models","volume":"226","author":"Gong","year":"2022","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"2025041407274132900_bib14","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.jmbbm.2016.03.010","article-title":"Prediction of denosumab effects on bone remodeling: a combined pharmacokinetics and finite element modeling [Article]","volume":"60","author":"Hambli","year":"2016","journal-title":"Journal of the Mechanical Behavior of Biomedical Materials"},{"key":"2025041407274132900_bib15","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/0021-9290(87)90030-3","article-title":"Adaptive bone-remodeling theory applied to prosthetic-design analysis","volume":"20","author":"Huiskes","year":"1987","journal-title":"Journal of Biomechanics"},{"key":"2025041407274132900_bib16","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/Bf03194355","article-title":"Diagnosis of osteoporosis","volume":"7","author":"Kanis","year":"1997","journal-title":"Osteoporosis International"},{"key":"2025041407274132900_bib17","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/s8756-3282(03)00157-1","article-title":"Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling","volume":"33","author":"Komarova","year":"2003","journal-title":"Bone"},{"key":"2025041407274132900_bib18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/470539","article-title":"Material properties of the mandibular trabecular bone","volume":"2014","author":"Lakatos","year":"2014","journal-title":"Journal of Medical Engineering"},{"key":"2025041407274132900_bib19","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.prosdent.2003.09.012","article-title":"Finite element analysis to determine implant preload [Article]","volume":"90","author":"Lang","year":"2003","journal-title":"Journal of Prosthetic Dentistry"},{"key":"2025041407274132900_bib20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2020.105863","article-title":"Biomechanical effects of dental implant diameter, connection type, and bone density on microgap formation and fatigue failure: a finite element analysis [Article]","volume":"200","author":"Lee","year":"2021","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"2025041407274132900_bib21","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.prosdent.2020.08.042","article-title":"Effects of implant diameter, implant-abutment connection type, and bone density on the biomechanical stability of implant components and bone: a finite element analysis study","volume":"128","author":"Lee","year":"2022","journal-title":"The Journal of Prosthetic Dentistry"},{"key":"2025041407274132900_bib22","doi-asserted-by":"publisher","first-page":"341","DOI":"10.4047\/jap.2019.11.6.341","article-title":"Effects of cementless fixation of implant prosthesis: a finite element study","volume":"11","author":"Lee","year":"2019","journal-title":"The Journal of Advanced Prosthodontics"},{"key":"2025041407274132900_bib23","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.prosdent.2018.07.013","article-title":"Biomechanical analysis of 4 types of short dental implants in a resorbed mandible","volume":"121","author":"Lee","year":"2019","journal-title":"The Journal of Prosthetic Dentistry"},{"key":"2025041407274132900_bib24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.prosdent.2015.08.021","article-title":"Effect of implant number and distribution on load transfer in implant-supported partial fixed dental prostheses for the anterior maxilla: a photoelastic stress analysis study","volume":"115","author":"Lee","year":"2016","journal-title":"Journal of Prosthetic Dentistry"},{"key":"2025041407274132900_bib25","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cmpb.2007.09.009","article-title":"Anisotropic finite element modeling for patient-specific mandible","volume":"88","author":"Liao","year":"2007","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"2025041407274132900_bib26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jbiomech.2009.08.024","article-title":"Mandibular bone remodeling induced by dental implant","volume":"43","author":"Lin","year":"2010","journal-title":"Journal of Biomechanics"},{"key":"2025041407274132900_bib27","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.jmbbm.2008.11.007","article-title":"Dental implant induced bone remodeling and associated algorithms [Review]","volume":"2","author":"Lin","year":"2009","journal-title":"Journal of the Mechanical Behavior of Biomedical Materials"},{"key":"2025041407274132900_bib28","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1600-0501.2004.01000.x","article-title":"Stimulating effect of implant loading on surrounding bone\u2014Comparison of three numerical models and validation by in vivo data [Article]","volume":"15","author":"Mellal","year":"2004","journal-title":"Clinical Oral Implants Research"},{"key":"2025041407274132900_bib29","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.cmpb.2010.03.006","article-title":"Modelling of mandible bone properties in the numerical analysis of oral implant biomechanics","volume":"100","author":"Natali","year":"2010","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"2025041407274132900_bib30","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0921-5093(97)00806-X","article-title":"Mechanical properties of biomedical titanium alloys [Article|Proceedings Paper]","volume":"243","author":"Niinomi","year":"1998","journal-title":"Materials Science and Engineering a-Structural Materials Properties Microstructure and Processing"},{"key":"2025041407274132900_bib31","doi-asserted-by":"publisher","first-page":"107376","DOI":"10.1016\/j.cmpb.2023.107376","article-title":"Optimization of thread configuration in dental implants through regulating the mechanical stimuli in neighboring bone","volume":"231","author":"Niroomand","year":"2023","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"2025041407274132900_bib32","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/j.1365-2842.2010.02076.x","article-title":"Impact of implant number, distribution and prosthesis material on loading on implants supporting fixed prostheses","volume":"37","author":"Ogawa","year":"2010","journal-title":"Journal of Oral Rehabilitation"},{"key":"2025041407274132900_bib33","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1034\/j.1600-0501.2001.120614.x","article-title":"Anisotropic elasticity of cortical and cancellous bone in the posterior mandible increases peri-implant stress and strain under oblique loading [Article]","volume":"12","author":"O'Mahony","year":"2001","journal-title":"Clinical Oral Implants Research"},{"key":"2025041407274132900_bib34","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1034\/j.1600-0501.2000.011005415.x","article-title":"Anisotropic elastic properties of cancellous bone from a human edentulous mandible","volume":"11","author":"O'Mahony","year":"2000","journal-title":"Clinical Oral Implants Research"},{"key":"2025041407274132900_bib35","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/jcde\/qwaa067","article-title":"Implant placement in the removable mandibular advancement device for completely edentulous patients: A finite element study","volume":"8","author":"Park","year":"2021","journal-title":"Journal of Computational Design and Engineering"},{"key":"2025041407274132900_bib36","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1093\/jcde\/qwac069","article-title":"Biomechanical effects of bone quality and design features in dental implants in long-term bone stability","volume":"9","author":"Park","year":"2022","journal-title":"Journal of Computational Design and Engineering"},{"key":"2025041407274132900_bib37","doi-asserted-by":"publisher","first-page":"106852","DOI":"10.1016\/j.cmpb.2022.106852","article-title":"Effects of assessing the bone remodeling process in biomechanical finite element stability evaluations of dental implants","volume":"221","author":"Park","year":"2022","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"2025041407274132900_bib38","doi-asserted-by":"publisher","first-page":"105258","DOI":"10.1016\/j.cmpb.2019.105258","article-title":"Finite element analysis and experimental evaluation on stress distribution and sensitivity of dental implants to assess optimum length and thread pitch","volume":"187","author":"Pirmoradian","year":"2020","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"2025041407274132900_bib39","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.jbiomech.2006.03.007","article-title":"Numerical estimation of bone density and elastic constants distribution in a human mandible","volume":"40","author":"Reina","year":"2007","journal-title":"Journal of Biomechanics"},{"key":"2025041407274132900_bib40","first-page":"99","article-title":"In vivo vertical forces on implants","volume":"10","author":"Richter","year":"1995","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"2025041407274132900_bib41","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1532-849x.1994.tb00124.x","article-title":"Cantilever and implant biomechanics: A review of the literature. Part 1","volume":"3","author":"Rodriguez","year":"1994","journal-title":"Journal of Prosthodontics"},{"key":"2025041407274132900_bib42","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s10237-014-0612-6","article-title":"Bone's responses to different designs of implant-supported fixed partial dentures","volume":"14","author":"Rungsiyakull","year":"2015","journal-title":"Biomechanics and Modeling in Mechanobiology"},{"key":"2025041407274132900_bib43","first-page":"339","article-title":"Influence of implant and conventional prostheses on satisfaction and quality of life: a literature review. Part 2: qualitative analysis and evaluation of the studies","volume":"19","author":"Strassburger","year":"2006","journal-title":"International Journal of Prosthodontics"},{"key":"2025041407274132900_bib44","doi-asserted-by":"publisher","first-page":"106365","DOI":"10.1016\/j.cmpb.2021.106365","article-title":"Modeling the musculoskeletal loading in bone remodeling at the hip of a child","volume":"210","author":"Terryn","year":"2021","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"2025041407274132900_bib45","first-page":"128","article-title":"In vitro study of a mandibular implant overdenture retained with ball, magnet, or bar attachments: comparison of load transfer and denture stability [Article]","volume":"16","author":"Tokuhisa","year":"2003","journal-title":"International Journal of Prosthodontics"},{"key":"2025041407274132900_bib46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jmbbm.2011.10.002","article-title":"Dynamic and static mechanical analysis of resin luting cements [Article]","volume":"6","author":"Tolidis","year":"2012","journal-title":"Journal of the Mechanical Behavior of Biomedical Materials"},{"key":"2025041407274132900_bib47","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/jab.770060408","article-title":"Finite element analysis of crestal bone loss around porous-coated dental implants","volume":"6","author":"Vaillancourt","year":"1995","journal-title":"Journal of Applied Biomaterials"},{"key":"2025041407274132900_bib48","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.jcde.2016.06.006","article-title":"Geometric and mechanical properties evaluation of scaffolds for bone tissue applications designing by a reaction-diffusion models and manufactured with a material jetting system","volume":"3","author":"Velasco","year":"2016","journal-title":"Journal of Computational Design and Engineering"},{"key":"2025041407274132900_bib49","doi-asserted-by":"publisher","first-page":"223","DOI":"10.4047\/jap.2022.14.4.223","article-title":"A retrospective comparison of clinical outcomes of implant restorations for posterior edentulous area: 3-unit bridge supported by 2 implants vs 3 splinted implant-supported crowns","volume":"14","author":"Yi","year":"2022","journal-title":"Journal of Advanced Prosthodontics"},{"key":"2025041407274132900_bib50","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00784-024-05589-3","article-title":"Biomechanical analysis of alveolar bones with compromised quality supporting a 4-unit implant bridge; a possible association with implant-related sequestration (IRS)","volume":"28","author":"Yoon","year":"2024","journal-title":"Clinical Oral Investigations"},{"key":"2025041407274132900_bib51","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1093\/jcde\/qwaa096","article-title":"Effect of mandibular contouring surgery on the stress distribution during various clenching tasks","volume":"8","author":"Yoon","year":"2021","journal-title":"Journal of Computational Design and Engineering"},{"key":"2025041407274132900_bib52","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1007\/s40846-023-00795-y","article-title":"Three-dimensional finite element stress analysis of different implant-supported bridges in the maxillary incisal regions","volume":"43","author":"Zhang","year":"2023","journal-title":"Journal of Medical and Biological Engineering"},{"key":"2025041407274132900_bib53","doi-asserted-by":"publisher","first-page":"107310","DOI":"10.1016\/j.cmpb.2022.10.7310","article-title":"Variation in stress distribution modified by mandibular material property: a 3D finite element analysis","volume":"229","author":"Zheng","year":"2023","journal-title":"Computer Methods and Programs in Biomedicine"}],"container-title":["Journal of Computational Design and Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcde\/advance-article-pdf\/doi\/10.1093\/jcde\/qwaf005\/61413946\/qwaf005.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcde\/article-pdf\/12\/2\/14\/61413946\/qwaf005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcde\/article-pdf\/12\/2\/14\/61413946\/qwaf005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T07:27:58Z","timestamp":1744615678000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcde\/article\/12\/2\/14\/7951741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jcde\/qwaf005","relation":{},"ISSN":["2288-5048"],"issn-type":[{"type":"electronic","value":"2288-5048"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2025,1,10]]}}}