{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:33:47Z","timestamp":1780684427734,"version":"3.54.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss Institute of Bioinformatics"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["183723"],"award-info":[{"award-number":["183723"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["186397"],"award-info":[{"award-number":["186397"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>OMA is an established resource to elucidate evolutionary relationships among genes from currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise orthologs, functional annotations, local and global gene order conservation (synteny) information, among many other functions. This update paper describes the reorganisation of the database into gene-, group- and genome-centric pages. Other new and improved features are detailed, such as reporting of the evolutionarily best conserved isoforms of alternatively spliced genes, the inferred local order of ancestral genes, phylogenetic profiling, better cross-references, fast genome mapping, semantic data sharing via RDF, as well as a special coronavirus OMA with 119 viruses from the Nidovirales order, including SARS-CoV-2, the agent of the COVID-19 pandemic. We conclude with improvements to the documentation of the resource through primers, tutorials and short videos. OMA is accessible at https:\/\/omabrowser.org.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1007","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T11:42:48Z","timestamp":1602762168000},"page":"D373-D379","source":"Crossref","is-referenced-by-count":221,"title":["OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more"],"prefix":"10.1093","volume":"49","author":[{"given":"Adrian M","family":"Altenhoff","sequence":"first","affiliation":[{"name":"SIB Swiss Institute of Bioinformatics,\u00a01015 Lausanne, Switzerland"},{"name":"ETH Zurich, Computer Science, Universit\u00e4tstr. 6,\u00a08092 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment-Marie","family":"Train","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, University of Lausanne,\u00a01015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly J","family":"Gilbert","sequence":"additional","affiliation":[{"name":"SIB Swiss Institute of Bioinformatics,\u00a01015 Lausanne, Switzerland"},{"name":"Department of Computational Biology, University of Lausanne,\u00a01015 Lausanne, Switzerland"},{"name":"Center for Integrative Genomics, University of Lausanne,\u00a01015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Mediratta","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, University of Lausanne,\u00a01015 Lausanne, Switzerland"},{"name":"Department of Computer Science and Information Systems,\u00a0BITS Pilani K.K. 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