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Their interaction is a fascinating and complex trait of the eukaryotic cell that MitImpact explores with its third major release. MitImpact expands its collection of genomic, clinical, and functional annotations of all non-synonymous substitutions of the human mitochondrial genome with new information on putative Compensated Pathogenic Deviations and co-varying amino acid sites of the Respiratory Chain subunits. It further provides evidence of energetic and structural residue compensation by techniques of molecular dynamics simulation. MitImpact is freely accessible at http:\/\/mitimpact.css-mendel.it.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1032","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T04:01:25Z","timestamp":1607486485000},"page":"D1282-D1288","source":"Crossref","is-referenced-by-count":40,"title":["MitImpact 3: modeling the residue interaction network of the Respiratory Chain subunits"],"prefix":"10.1093","volume":"49","author":[{"given":"Stefano","family":"Castellana","sequence":"first","affiliation":[{"name":"Laboratory of Bioinformatics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), 71013, Italy"}]},{"given":"Tommaso","family":"Biagini","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), 71013, Italy"}]},{"given":"Francesco","family":"Petrizzelli","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), 71013, Italy"},{"name":"Department of Experimental Medicine, Sapienza University of Rome, Rome\u00a000161, Italy"}]},{"given":"Luca","family":"Parca","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), 71013, Italy"}]},{"given":"Noemi","family":"Panzironi","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome, Rome\u00a000161, Italy"}]},{"given":"Viviana","family":"Caputo","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome, Rome\u00a000161, Italy"}]},{"given":"Angelo Luigi","family":"Vescovi","sequence":"additional","affiliation":[{"name":"ISBReMIT Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapies, IRCSS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), 71013, Italy"}]},{"given":"Massimo","family":"Carella","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG)\u00a071013, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0434-8533","authenticated-orcid":false,"given":"Tommaso","family":"Mazza","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), 71013, Italy"}]}],"member":"286","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"2021010313140033400_B1","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.3201231","article-title":"Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy","volume":"242","author":"Wallace","year":"1988","journal-title":"Science"},{"key":"2021010313140033400_B2","doi-asserted-by":"crossref","first-page":"16080","DOI":"10.1038\/nrdp.2016.80","article-title":"Mitochondrial diseases","volume":"2","author":"Gorman","year":"2016","journal-title":"Nat. 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