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To systematically prioritize the oncogenic ability of somatic mutations and cancer genes, we constructed a useful platform, OncoVar (https:\/\/oncovar.org\/), which employed published bioinformatics algorithms and incorporated known driver events to identify driver mutations and driver genes. We identified 20 162 cancer driver mutations, 814 driver genes and 2360 pathogenic pathways with high-confidence by reanalyzing 10 769 exomes from 33 cancer types in The Cancer Genome Atlas (TCGA) and 1942 genomes from 18 cancer types in International Cancer Genome Consortium (ICGC). OncoVar provides four points of view, \u2018Mutation\u2019, \u2018Gene\u2019, \u2018Pathway\u2019 and \u2018Cancer\u2019, to help researchers to visualize the relationships between cancers and driver variants. Importantly, identification of actionable driver alterations provides promising druggable targets and repurposing opportunities of combinational therapies. OncoVar provides a user-friendly interface for browsing, searching and downloading somatic driver mutations, driver genes and pathogenic pathways in various cancer types. This platform will facilitate the identification of cancer drivers across individual cancer cohorts and helps to rank mutations or genes for better decision-making among clinical oncologists, cancer researchers and the broad scientific community interested in cancer precision medicine.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1033","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T15:21:37Z","timestamp":1603120897000},"page":"D1289-D1301","source":"Crossref","is-referenced-by-count":87,"title":["OncoVar: an integrated database and analysis platform for oncogenic driver variants in cancers"],"prefix":"10.1093","volume":"49","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan 410083, China"},{"name":"Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China"}]},{"given":"Shasha","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430072, China"}]},{"given":"Xiaolu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"}]},{"given":"Xiaohui","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China"}]},{"given":"Huajing","family":"Teng","sequence":"additional","affiliation":[{"name":"Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China"}]},{"given":"Jianing","family":"Zhong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou 341000, China"}]},{"given":"Mingcong","family":"You","sequence":"additional","affiliation":[{"name":"Baiyining Medicine, Beijing 102200, China"}]},{"given":"Kun","family":"Xia","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan 410083, China"},{"name":"CAS Center for Excellence in Brain Science and Intelligences Technology (CEBSIT), Shanghai 200031, China"},{"name":"School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China"}]},{"given":"Zhongsheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"State Key Laboratory of Integrated Management of Pest Insects and Rodents, Chinese Academy of Sciences, Beijing 100101, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-4266","authenticated-orcid":false,"given":"Fengbiao","family":"Mao","sequence":"additional","affiliation":[{"name":"Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing 100191, China"}]}],"member":"286","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"2021010313122700500_B1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nrg3031","article-title":"Exome sequencing as a tool for Mendelian disease gene discovery","volume":"12","author":"Bamshad","year":"2011","journal-title":"Nat. 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