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However, the expression, functions and evolution of these ncRNAs are still largely unknown. In this study, we have updated deepBase to version 3.0 (deepBase v3.0, http:\/\/rna.sysu.edu.cn\/deepbase3\/index.html), an increasingly popular and openly licensed resource that facilitates integrative and interactive display and analysis of the expression, evolution, and functions of various ncRNAs by deeply mining thousands of high-throughput sequencing data from tissue, tumor and exosome samples. We updated deepBase v3.0 to provide the most comprehensive expression atlas of small RNAs and lncRNAs by integrating \u223c67 620 data from 80 normal tissues and \u223c50 cancer tissues. The extracellular patterns of various ncRNAs were profiled to explore their applications for discovery of noninvasive biomarkers. Moreover, we constructed survival maps of tRNA-derived RNA Fragments (tRFs), miRNAs, snoRNAs and lncRNAs by analyzing &amp;gt;45 000 cancer sample data and corresponding clinical information. We also developed interactive webs to analyze the differential expression and biological functions of various ncRNAs in \u223c50 types of cancers. This update is expected to provide a variety of new modules and graphic visualizations to facilitate analyses and explorations of the functions and mechanisms of various types of ncRNAs.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1039","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T19:10:08Z","timestamp":1602961808000},"page":"D877-D883","source":"Crossref","is-referenced-by-count":53,"title":["deepBase v3.0: expression atlas and interactive analysis of ncRNAs from thousands of deep-sequencing data"],"prefix":"10.1093","volume":"49","author":[{"given":"Fangzhou","family":"Xie","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275,\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Liu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275,\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Wang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275,\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Xuan","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275,\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, South China University of Technology, Guangzhou\u00a0510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-2863","authenticated-orcid":false,"given":"Lianghu","family":"Qu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275,\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-1095","authenticated-orcid":false,"given":"Lingling","family":"Zheng","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275,\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3863-2786","authenticated-orcid":false,"given":"Jianhua","family":"Yang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275,\u00a0China"},{"name":"Department of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai\u00a0519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"2021010313114574500_B1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cell.2014.03.008","article-title":"The noncoding RNA revolution-trashing old rules to forge new ones","volume":"157","author":"Cech","year":"2014","journal-title":"Cell"},{"key":"2021010313114574500_B2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-genet-112414-054804","article-title":"Accelerating discovery and functional analysis of small RNAs with new technologies","volume":"49","author":"Barquist","year":"2015","journal-title":"Annu. 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