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To further deepen our knowledge of RNA-binding proteins (RBPs), multiple proteome-wide strategies have been developed to identify RBPs in different species leading to a large number of studies contributing experimentally identified as well as predicted RBP candidate catalogs. However, the rapid evolution of the field led to an accumulation of isolated datasets, hampering the access and comparison of their valuable content. Moreover, tools to link RBPs to cellular pathways and functions were lacking. Here, to facilitate the efficient screening of the RBP resources, we provide RBP2GO (https:\/\/RBP2GO.DKFZ.de), a comprehensive database of all currently available proteome-wide datasets for RBPs across 13 species from 53 studies including 105 datasets identifying altogether 22\u00a0552 RBP candidates. These are combined with the information on RBP interaction partners and on the related biological processes, molecular functions and cellular compartments. RBP2GO offers a user-friendly web interface with an RBP scoring system and powerful advanced search tools allowing forward and reverse searches connecting functions and RBPs to stimulate new research directions.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1040","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T20:13:29Z","timestamp":1603916009000},"page":"D425-D436","source":"Crossref","is-referenced-by-count":123,"title":["RBP2GO: a comprehensive pan-species database on RNA-binding proteins, their interactions and functions"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-8153","authenticated-orcid":false,"given":"Maiwen","family":"Caudron-Herger","sequence":"first","affiliation":[{"name":"Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf E","family":"Jansen","sequence":"additional","affiliation":[{"name":"Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Wassmer","sequence":"additional","affiliation":[{"name":"Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7901-4752","authenticated-orcid":false,"given":"Sven","family":"Diederichs","sequence":"additional","affiliation":[{"name":"Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"},{"name":"Division of Cancer Research, Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK) - Partner Site Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"2021010313130898900_B1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/bfgp\/elq028","article-title":"Deciphering the role of RNA-binding proteins in the post-transcriptional control of gene expression","volume":"9","author":"Kishore","year":"2010","journal-title":"Brief. 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