{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:30:57Z","timestamp":1781731857137,"version":"3.54.5"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M011690\/1"],"award-info":[{"award-number":["BB\/M011690\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/S020462\/1"],"award-info":[{"award-number":["BB\/S020462\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["654039"],"award-info":[{"award-number":["654039"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007569","name":"Carl Zeiss Foundation","doi-asserted-by":"publisher","award":["0563-2.8\/738\/2"],"award-info":[{"award-number":["0563-2.8\/738\/2"]}],"id":[{"id":"10.13039\/100007569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["R01-HG009116"],"award-info":[{"award-number":["R01-HG009116"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","award":["MA5082\/7-1"],"award-info":[{"award-number":["MA5082\/7-1"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rfam is a database of RNA families where each of the 3444 families is represented by a multiple sequence alignment of known RNA sequences and a covariance model that can be used to search for additional members of the family. Recent developments have involved expert collaborations to improve the quality and coverage of Rfam data, focusing on microRNAs, viral and bacterial RNAs. We have completed the first phase of synchronising microRNA families in Rfam and miRBase, creating 356 new Rfam families and updating 40. We established a procedure for comprehensive annotation of viral RNA families starting with Flavivirus and Coronaviridae RNAs. We have also increased the coverage of bacterial and metagenome-based RNA families from the ZWD database. These developments have enabled a significant growth of the database, with the addition of 759 new families in Rfam 14. To facilitate further community contribution to Rfam, expert users are now able to build and submit new families using the newly developed Rfam Cloud family curation system. New Rfam website features include a new sequence similarity search powered by RNAcentral, as well as search and visualisation of families with pseudoknots. Rfam is freely available at https:\/\/rfam.org.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1047","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T19:12:51Z","timestamp":1603307571000},"page":"D192-D200","source":"Crossref","is-referenced-by-count":1007,"title":["Rfam 14: expanded coverage of metagenomic, viral and microRNA families"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-9197","authenticated-orcid":false,"given":"Ioanna","family":"Kalvari","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2497-3427","authenticated-orcid":false,"given":"Eric P","family":"Nawrocki","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8457-4455","authenticated-orcid":false,"given":"Nancy","family":"Ontiveros-Palacios","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2678-2824","authenticated-orcid":false,"given":"Joanna","family":"Argasinska","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6375-6441","authenticated-orcid":false,"given":"Kevin","family":"Lamkiewicz","sequence":"additional","affiliation":[{"name":"RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University Jena, Leutragraben 1, 07743 Jena, Germany"},{"name":"European Virus Bioinformatics Center, Leutragraben 1, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-8823","authenticated-orcid":false,"given":"Manja","family":"Marz","sequence":"additional","affiliation":[{"name":"RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University Jena, Leutragraben 1, 07743 Jena, Germany"},{"name":"European Virus Bioinformatics Center, Leutragraben 1, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-807X","authenticated-orcid":false,"given":"Sam","family":"Griffiths-Jones","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-6844","authenticated-orcid":false,"given":"Claire","family":"Toffano-Nioche","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1508-8469","authenticated-orcid":false,"given":"Daniel","family":"Gautheret","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6681-3624","authenticated-orcid":false,"given":"Zasha","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Department of Computer Science and Interdisciplinary Centre for Bioinformatics, Leipzig University, 04107 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2084-269X","authenticated-orcid":false,"given":"Elena","family":"Rivas","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6676-4706","authenticated-orcid":false,"given":"Sean R","family":"Eddy","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA"},{"name":"Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA"},{"name":"John A. Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA 02138, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8626-2148","authenticated-orcid":false,"given":"Robert\u00a0D","family":"Finn","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6982-4660","authenticated-orcid":false,"given":"Alex","family":"Bateman","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7279-2682","authenticated-orcid":false,"given":"Anton I","family":"Petrov","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"2021010313131016100_B1","doi-asserted-by":"crossref","first-page":"D335","DOI":"10.1093\/nar\/gkx1038","article-title":"Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families","volume":"46","author":"Kalvari","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B2","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1093\/bioinformatics\/btt509","article-title":"Infernal 1.1: 100-fold faster RNA homology searches","volume":"29","author":"Nawrocki","year":"2013","journal-title":"Bioinformatics"},{"key":"2021010313131016100_B3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41586-020-2561-9","article-title":"The tuatara genome reveals ancient features of amniote evolution","volume":"584","author":"Gemmell","year":"2020","journal-title":"Nature"},{"key":"2021010313131016100_B4","first-page":"giy119","article-title":"The genome of common long-arm octopus Octopus minor","volume":"7","author":"Kim","year":"2018","journal-title":"Gigascience"},{"key":"2021010313131016100_B5","first-page":"D682","article-title":"Ensembl 2020","volume":"48","author":"Yates","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B6","doi-asserted-by":"crossref","first-page":"D689","DOI":"10.1093\/nar\/gkz890","article-title":"Ensembl genomes 2020\u2014enabling non-vertebrate genomic research","volume":"48","author":"Howe","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B7","doi-asserted-by":"crossref","first-page":"D851","DOI":"10.1093\/nar\/gkx1068","article-title":"RefSeq: an update on prokaryotic genome annotation and curation","volume":"46","author":"Haft","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B8","doi-asserted-by":"crossref","first-page":"D733","DOI":"10.1093\/nar\/gkv1189","article-title":"Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation","volume":"44","author":"O\u2019Leary","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B9","first-page":"D335","article-title":"PDBe: improved findability of macromolecular structure data in the PDB","volume":"48","author":"Armstrong","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B10","doi-asserted-by":"crossref","first-page":"D221","DOI":"10.1093\/nar\/gky1034","article-title":"RNAcentral: a hub of information for non-coding RNA sequences","volume":"47","author":"The RNAcentral Consortium","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B11","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1093\/nar\/gkt101","article-title":"CompaRNA: a server for continuous benchmarking of automated methods for RNA secondary structure prediction","volume":"41","author":"Puton","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B12","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1093\/bioinformatics\/btl246","article-title":"CONTRAfold: RNA secondary structure prediction without physics-based models","volume":"22","author":"Do","year":"2006","journal-title":"Bioinformatics"},{"key":"2021010313131016100_B13","first-page":"D70","article-title":"The European Nucleotide Archive in 2019","volume":"48","author":"Amid","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B14","doi-asserted-by":"crossref","first-page":"10811","DOI":"10.1093\/nar\/gkx699","article-title":"Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions","volume":"45","author":"Weinberg","year":"2017","journal-title":"Nucleic Acids"},{"key":"2021010313131016100_B15","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12866-020-01823-6","article-title":"Discovery of 20 novel ribosomal leader candidates in bacteria and archaea","volume":"20","author":"Eckert","year":"2020","journal-title":"BMC Microbiol."},{"key":"2021010313131016100_B16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nmeth.4066","article-title":"A statistical test for conserved RNA structure shows lack of evidence for structure in lncRNAs","volume":"14","author":"Rivas","year":"2017","journal-title":"Nat. Methods"},{"key":"2021010313131016100_B17","doi-asserted-by":"crossref","DOI":"10.1101\/2020.02.04.933952","article-title":"RNA structure prediction using positive and negative evolutionary information","author":"Rivas","year":"2020"},{"key":"2021010313131016100_B18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.virol.2017.11.025","article-title":"Structural and functional conservation of cis-acting RNA elements in coronavirus 5\u2032-terminal genome regions","volume":"517","author":"Madhugiri","year":"2018","journal-title":"Virology"},{"key":"2021010313131016100_B19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0022-2836(87)90455-4","article-title":"Conserved elements in the 3\u2032 untranslated region of flavivirus RNAs and potential cyclization sequences","volume":"198","author":"Hahn","year":"1987","journal-title":"J. Mol. Biol."},{"key":"2021010313131016100_B20","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1128\/JVI.79.11.6631-6643.2005","article-title":"Long-range RNA-RNA interactions circularize the dengue virus genome","volume":"79","author":"Alvarez","year":"2005","journal-title":"J. Virol."},{"key":"2021010313131016100_B21","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/resp.13196","article-title":"MERS, SARS and other coronaviruses as causes of pneumonia","volume":"23","author":"Yin","year":"2018","journal-title":"Respirology"},{"key":"2021010313131016100_B22","doi-asserted-by":"crossref","first-page":"e105067","DOI":"10.1371\/journal.pone.0105067","article-title":"Profile hidden Markov models for the detection of viruses within metagenomic sequence data","volume":"9","author":"Skewes-Cox","year":"2014","journal-title":"PLoS One"},{"key":"2021010313131016100_B23","doi-asserted-by":"crossref","first-page":"530","DOI":"10.12688\/f1000research.18776.2","article-title":"RVDB-prot, a reference viral protein database and its HMM profiles","volume":"8","author":"Bigot","year":"2020","journal-title":"F1000Res."},{"key":"2021010313131016100_B24","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaa232","article-title":"Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research","author":"Hufsky","year":"2020"},{"key":"2021010313131016100_B25","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1261\/rna.029041.111","article-title":"LocARNA-P: accurate boundary prediction and improved detection of structural RNAs","volume":"18","author":"Will","year":"2012","journal-title":"RNA"},{"key":"2021010313131016100_B26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.virusres.2014.10.001","article-title":"RNA structure analysis of alphacoronavirus terminal genome regions","volume":"194","author":"Madhugiri","year":"2014","journal-title":"Virus Res."},{"key":"2021010313131016100_B27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4161\/rna.8.2.14991","article-title":"RNA-RNA and RNA-protein interactions in coronavirus replication and transcription","volume":"8","author":"Sola","year":"2011","journal-title":"RNA Biol."},{"key":"2021010313131016100_B28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.virusres.2015.02.025","article-title":"The structure and functions of coronavirus genomic 3\u2032 and 5\u2032 ends","volume":"206","author":"Yang","year":"2015","journal-title":"Virus Res."},{"key":"2021010313131016100_B29","doi-asserted-by":"crossref","first-page":"D593","DOI":"10.1093\/nar\/gkr859","article-title":"ViPR: an open bioinformatics database and analysis resource for virology research","volume":"40","author":"Pickett","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/v11030298","article-title":"Functional RNA structures in the 3\u2032UTR of tick-borne, insect-specific and no-known-vector flaviviruses","volume":"11","author":"Ochsenreiter","year":"2019","journal-title":"Viruses"},{"key":"2021010313131016100_B31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/JVI.72.1.73-83.1998","article-title":"Phylogeny of the genus Flavivirus","volume":"72","author":"Kuno","year":"1998","journal-title":"J. Virol."},{"key":"2021010313131016100_B32","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1099\/0022-1317-82-8-1867","article-title":"Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography","volume":"82","author":"Gaunt","year":"2001","journal-title":"J. Gen. Virol."},{"key":"2021010313131016100_B33","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.virol.2006.09.039","article-title":"Genetic characterization of a new insect flavivirus isolated from Culex pipiens mosquito in Japan","volume":"359","author":"Hoshino","year":"2007","journal-title":"Virology"},{"key":"2021010313131016100_B34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0065-3527(06)69005-2","article-title":"Origin and evolution of 3\u2032UTR of flaviviruses: long direct repeats as a basis for the formation of secondary structures and their significance for virus transmission","volume":"69","author":"Gritsun","year":"2007","journal-title":"Adv. Virus Res."},{"key":"2021010313131016100_B35","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1371\/journal.pcbi.0030065","article-title":"Inferring noncoding RNA families and classes by means of genome-scale structure-based clustering","volume":"3","author":"Will","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"2021010313131016100_B36","first-page":"69","article-title":"RNAz 2.0: improved noncoding RNA detection","volume":"2010","author":"Gruber","year":"2010","journal-title":"Pac. Symp. Biocomput."},{"key":"2021010313131016100_B37","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.3389\/fimmu.2018.02097","article-title":"RNA structure-a neglected puppet master for the evolution of virus and host immunity","volume":"9","author":"Smyth","year":"2018","journal-title":"Front. Immunol."},{"key":"2021010313131016100_B38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12291-019-00844-x","article-title":"MicroRNAs and diseases: promising biomarkers for diagnosis and therapeutics","volume":"34","author":"Dwivedi","year":"2019","journal-title":"Indian J. Clin. Biochem."},{"key":"2021010313131016100_B39","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/imr.12054","article-title":"mir-17-92: a polycistronic oncomir with pleiotropic functions","volume":"253","author":"Olive","year":"2013","journal-title":"Immunol. Rev."},{"key":"2021010313131016100_B40","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B41","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"2021010313131016100_B42","doi-asserted-by":"crossref","first-page":"giz150","DOI":"10.1093\/gigascience\/giz150","article-title":"GraphClust2: annotation and discovery of structured RNAs with scalable and accessible integrative clustering","volume":"8","author":"Miladi","year":"2019","journal-title":"Gigascience"},{"key":"2021010313131016100_B43","doi-asserted-by":"crossref","first-page":"8433","DOI":"10.1093\/nar\/gkw558","article-title":"RNAlien - unsupervised RNA family model construction","volume":"44","author":"Eggenhofer","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B44","doi-asserted-by":"crossref","first-page":"e1003493","DOI":"10.1371\/journal.pgen.1003493","article-title":"Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile","volume":"9","author":"Soutourina","year":"2013","journal-title":"PLoS Genet."},{"key":"2021010313131016100_B45","doi-asserted-by":"crossref","first-page":"e10725","DOI":"10.1371\/journal.pone.0010725","article-title":"Cartography of methicillin-resistant S. aureus transcripts: detection, orientation and temporal expression during growth phase and stress conditions","volume":"5","author":"Beaume","year":"2010","journal-title":"PLoS One"},{"key":"2021010313131016100_B46","doi-asserted-by":"crossref","first-page":"W636","DOI":"10.1093\/nar\/gkz268","article-title":"The EMBL-EBI search and sequence analysis tools APIs in 2019","volume":"47","author":"Madeira","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2105-12-3","article-title":"R2R\u2013software to speed the depiction of aesthetic consensus RNA secondary structures","volume":"12","author":"Weinberg","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2021010313131016100_B48","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1093\/bioinformatics\/btt403","article-title":"nhmmer: DNA homology search with profile HMMs","volume":"29","author":"Wheeler","year":"2013","journal-title":"Bioinformatics"},{"key":"2021010313131016100_B49","doi-asserted-by":"crossref","first-page":"D130","DOI":"10.1093\/nar\/gku1063","article-title":"Rfam 12.0: updates to the RNA families database","volume":"43","author":"Nawrocki","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2021010313131016100_B50","doi-asserted-by":"crossref","DOI":"10.1101\/2020.09.10.290924","article-title":"R2DT: computational framework for template-based RNA secondary structure visualisation across non-coding RNA types","author":"Sweeney","year":"2020"},{"key":"2021010313131016100_B51","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1002\/cpbi.51","article-title":"Non-coding RNA analysis using the Rfam database","volume":"62","author":"Kalvari","year":"2018","journal-title":"Curr. Protoc. Bioinformatics"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/49\/D1\/D192\/35364695\/gkaa1047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/49\/D1\/D192\/35364695\/gkaa1047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T21:17:04Z","timestamp":1618003024000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/49\/D1\/D192\/5992291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":51,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2020,11,19]]},"published-print":{"date-parts":[[2021,1,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkaa1047","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,8]]},"published":{"date-parts":[[2020,11,19]]}}}