{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:40:27Z","timestamp":1772952027717,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C35696\/A23187"],"award-info":[{"award-number":["C35696\/A23187"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CRUK Cancer Therapeutics Unit","award":["C309\/A25144"],"award-info":[{"award-number":["C309\/A25144"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT212969\/Z\/18\/Z"],"award-info":[{"award-number":["WT212969\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sir Henry Wellcome","award":["WT204735\/Z\/16\/Z"],"award-info":[{"award-number":["WT204735\/Z\/16\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>canSAR (http:\/\/cansar.icr.ac.uk) is the largest, public, freely available, integrative translational research and drug discovery knowledgebase for oncology. canSAR integrates vast multidisciplinary data from across genomic, protein, pharmacological, drug and chemical data with structural biology, protein networks\u00a0and more. It also provides unique data, curation and annotation and crucially, AI-informed target assessment for drug discovery. canSAR is widely used internationally by academia and industry. Here we describe significant developments and enhancements to the data, web interface and infrastructure of canSAR in the form of the new implementation of the system: canSARblack. We demonstrate new functionality in aiding translation hypothesis generation and experimental design, and show how canSAR can be adapted and utilised outside oncology.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1059","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T20:13:46Z","timestamp":1603829626000},"page":"D1074-D1082","source":"Crossref","is-referenced-by-count":89,"title":["canSAR: update to the cancer translational research and drug discovery knowledgebase"],"prefix":"10.1093","volume":"49","author":[{"given":"Costas","family":"Mitsopoulos","sequence":"first","affiliation":[{"name":"Department of Data Science, The Institute of Cancer Research, London SM2 5NG, UK"},{"name":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK"}]},{"given":"Patrizio","family":"Di\u00a0Micco","sequence":"additional","affiliation":[{"name":"Department of Data Science, The Institute of Cancer Research, London SM2 5NG, UK"}]},{"given":"Eloy Villasclaras","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Data Science, The Institute of Cancer Research, London SM2 5NG, UK"}]},{"given":"Daniela","family":"Dolciami","sequence":"additional","affiliation":[{"name":"Department of Data Science, The Institute of Cancer Research, London SM2 5NG, UK"},{"name":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK"}]},{"given":"Esty","family":"Holt","sequence":"additional","affiliation":[{"name":"Department of Data Science, The Institute of Cancer Research, London SM2 5NG, UK"}]},{"given":"Ioan L","family":"Mica","sequence":"additional","affiliation":[{"name":"Department of Data Science, The Institute of Cancer Research, London SM2 5NG, UK"}]},{"given":"Elizabeth A","family":"Coker","sequence":"additional","affiliation":[{"name":"Department of Data Science, The Institute of Cancer Research, London SM2 5NG, UK"}]},{"given":"Joseph 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